K22O_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K22O_MOUSE
• UniProt AC: Q3UV17
• Protein Name: Keratin, type II cytoskeletal 2 oral {ECO:0000250|UniProtKB:Q01546}
• Gene Name: Krt76 {ECO:0000312|MGI:MGI:1924305}
• Organism: Mus musculus (Mouse).
• Sequence Length: 594
• Protein Description: Probably contributes to terminal cornification..
• Protein Sequence: MSRQACKKSFSCGSQGFSGHSAVVSGSSRSSCVARSGAASGGACGFRSGAGSLGSHSLYSLGGSKSISISVAAGGSRAGGFSGGRSSCGSGFGSGYGGSLGGSRGMGAGFGGPSGFGGAGGFGRPGSFGPGSCPGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTIRSGSGPQNLEPFFESYISCLRKQLDSLLGAKGSLEGELKSMQDLVEDFKKKYEEEINRRTAAENEFVGLKKDVDGAFMNKVELQAKVDSLTDEINFLRTLYDMELSQIQSHVSDTSVVLSMDNNRCLDLDSIIAEVKAQYEDIAQKSKAEAEALYQTKLGELQTTAGRHGDDLRSTKSEIMDLNRMIQRLRAEIENVKKQNTNMQTSIAEAEQRGERALKDADTKFQDLQVALQKAKEDMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLSGEFQNAVSISVVSNVTSTSSSGSFRGTGGSNYGGDSSGRSGGSSSSSSRGSSSRGSSGSRLGSGGSISVSQQRMGFNSGGSQTSVGSSYKSGRGGSSSVQFSQTTSSSQQRSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	SCGSQGFSGHSAVVS CCCCCCCCCCEEEEE	42.28	-
21	Phosphorylation	SQGFSGHSAVVSGSS CCCCCCCEEEEECCC	26.70	-
57	Phosphorylation	AGSLGSHSLYSLGGS CCCCCCCEEEECCCC	30.60	22817900
60	Phosphorylation	LGSHSLYSLGGSKSI CCCCEEEECCCCCEE	26.32	21183079
85	Methylation	AGGFSGGRSSCGSGF CCCCCCCCCCCCCCC	28.99	-
90	Phosphorylation	GGRSSCGSGFGSGYG CCCCCCCCCCCCCCC	34.96	-
94	Phosphorylation	SCGSGFGSGYGGSLG CCCCCCCCCCCCCCC	26.95	26160508
96	Phosphorylation	GSGFGSGYGGSLGGS CCCCCCCCCCCCCCC	21.73	26160508
99	Phosphorylation	FGSGYGGSLGGSRGM CCCCCCCCCCCCCCC	21.34	26160508
103	Phosphorylation	YGGSLGGSRGMGAGF CCCCCCCCCCCCCCC	24.70	26643407
104	Methylation	GGSLGGSRGMGAGFG CCCCCCCCCCCCCCC	42.25	-
171	Phosphorylation	QEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	29899451
175	Ubiquitination	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	-
178	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22817900
182	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	27667366
351	Acetylation	QYEDIAQKSKAEAEA HHHHHHHHHHHHHHH	44.92	23806337
351	Succinylation	QYEDIAQKSKAEAEA HHHHHHHHHHHHHHH	44.92	23806337
471	Ubiquitination	VEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	27667366
517	Phosphorylation	GSNYGGDSSGRSGGS CCCCCCCCCCCCCCC	37.66	28285833
518	Phosphorylation	SNYGGDSSGRSGGSS CCCCCCCCCCCCCCC	42.86	28285833
526	Phosphorylation	GRSGGSSSSSSRGSS CCCCCCCCCCCCCCC	35.62	28285833
527	Phosphorylation	RSGGSSSSSSRGSSS CCCCCCCCCCCCCCC	33.99	28285833
528	Phosphorylation	SGGSSSSSSRGSSSR CCCCCCCCCCCCCCC	26.46	28285833
529	Phosphorylation	GGSSSSSSRGSSSRG CCCCCCCCCCCCCCC	42.48	28285833
541	Methylation	SRGSSGSRLGSGGSI CCCCCCCCCCCCCCE	46.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K22O_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K22O_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K22O_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K22O_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.