FRM4A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRM4A_MOUSE
• UniProt AC: Q8BIE6
• Protein Name: FERM domain-containing protein 4A
• Gene Name: Frmd4a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1020
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, adherens junction . Cell junction, tight junction . Colocalized with CYTH1 at adherens junction and tight junction (PubMed:20080746). Colocalized with PARD3 during the process of epithelial polarization (PubMed
• Protein Description: Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. [PubMed: 20080746 Plays a redundant role with FRMD4B in epithelial polarization]
• Protein Sequence: MTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEYYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLVIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLQSPHKGLPPRPPSSHNRPPPPQSLEGLRQLHYHRTDYDKSPLKPKMWSESSLDEPYEKVKKRSSHGHSSSHKRFPSTGSCTEAGVSSSLQNSPIRSLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGALGSASSGSMPNLAARSGAASTGGGVYLHSQSQPSSQYRIKEYPLYIEGSATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGDEGDAGRLTPSRSQILRTPSLGRDGAHDKGSGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEATENSPIMDGSESPTHQSTDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Ubiquitination	VASHFNLKEKEYFGI HHHHCCCCCHHEEEE	68.77	-
266	Phosphorylation	VHDPRRASVTRRTFG ECCCCCCEECCCCCC	23.39	22324799
268	Phosphorylation	DPRRASVTRRTFGHS CCCCCEECCCCCCCC	16.37	22324799
309	Phosphorylation	FYLDRKQSKSKIHAA HHHCHHHHHHHHHHH	41.76	-
318	Phosphorylation	SKIHAARSLSEIAID HHHHHHHHHHHHCEE	31.36	20415495
320	Phosphorylation	IHAARSLSEIAIDLT HHHHHHHHHHCEEEC	28.36	19060867
329	Phosphorylation	IAIDLTETGTLKTSK HCEEECCCCCCCHHH	30.17	29899451
342	Phosphorylation	SKLANMGSKGKIISG HHHCCCCCCCCEEEC	27.71	28066266
348	Phosphorylation	GSKGKIISGSSGSLL CCCCCEEECCCCCCC	35.77	25619855
350	Phosphorylation	KGKIISGSSGSLLSS CCCEEECCCCCCCCC	25.41	25619855
351	Phosphorylation	GKIISGSSGSLLSSG CCEEECCCCCCCCCC	35.61	25619855
353	Phosphorylation	IISGSSGSLLSSGSQ EEECCCCCCCCCCCC	28.25	25619855
356	Phosphorylation	GSSGSLLSSGSQESD CCCCCCCCCCCCCCC	37.64	25619855
357	Phosphorylation	SSGSLLSSGSQESDS CCCCCCCCCCCCCCC	42.29	25619855
359	Phosphorylation	GSLLSSGSQESDSSQ CCCCCCCCCCCCCCH	32.49	25619855
362	Phosphorylation	LSSGSQESDSSQSAK CCCCCCCCCCCHHHH	34.85	25619855
364	Phosphorylation	SGSQESDSSQSAKKD CCCCCCCCCHHHHHH	39.29	25619855
365	Phosphorylation	GSQESDSSQSAKKDM CCCCCCCCHHHHHHH	32.90	25619855
367	Phosphorylation	QESDSSQSAKKDMLA CCCCCCHHHHHHHHH	43.96	25619855
432	Ubiquitination	RRIGTAFKLDEQKIL CCCEEEEECCHHHCC	53.19	-
437	Ubiquitination	AFKLDEQKILPKGEE EEECCHHHCCCCCCH	44.13	-
469	Phosphorylation	EAARRLASDPNVSKK HHHHHHHCCCCHHHH	59.18	25338131
515	Phosphorylation	KKPTQRASLVIDDGN CCCCCCEEEEEECCC	25.92	25619855
585	Phosphorylation	RQLHYHRTDYDKSPL HHHHCCCCCCCCCCC	26.12	25777480
590	Phosphorylation	HRTDYDKSPLKPKMW CCCCCCCCCCCCCCC	32.35	27742792
598	Phosphorylation	PLKPKMWSESSLDEP CCCCCCCCCCCCCCC	24.89	22807455
600	Phosphorylation	KPKMWSESSLDEPYE CCCCCCCCCCCCCHH	30.59	28066266
601	Phosphorylation	PKMWSESSLDEPYEK CCCCCCCCCCCCHHH	35.47	19060867
606	Phosphorylation	ESSLDEPYEKVKKRS CCCCCCCHHHHHHHH	26.74	18515860
613	Phosphorylation	YEKVKKRSSHGHSSS HHHHHHHHCCCCCCC	35.25	25266776
620	Phosphorylation	SSHGHSSSHKRFPST HCCCCCCCCCCCCCC	35.72	-
626	Phosphorylation	SSHKRFPSTGSCTEA CCCCCCCCCCCCCHH	42.56	25619855
627	Phosphorylation	SHKRFPSTGSCTEAG CCCCCCCCCCCCHHC	33.09	25619855
629	Phosphorylation	KRFPSTGSCTEAGVS CCCCCCCCCCHHCCC	20.25	25619855
631	Phosphorylation	FPSTGSCTEAGVSSS CCCCCCCCHHCCCHH	30.48	25619855
636	Phosphorylation	SCTEAGVSSSLQNSP CCCHHCCCHHHCCCC	17.19	25619855
637	Phosphorylation	CTEAGVSSSLQNSPI CCHHCCCHHHCCCCC	32.44	25619855
638	Phosphorylation	TEAGVSSSLQNSPIR CHHCCCHHHCCCCCC	26.86	25619855
642	Phosphorylation	VSSSLQNSPIRSLPH CCHHHCCCCCCCCCC	14.56	25619855
646	Phosphorylation	LQNSPIRSLPHWNSQ HCCCCCCCCCCCCCC	47.15	23984901
652	Phosphorylation	RSLPHWNSQSSMPST CCCCCCCCCCCCCCC	26.67	21743459
654	Phosphorylation	LPHWNSQSSMPSTPD CCCCCCCCCCCCCCC	28.55	21743459
655	Phosphorylation	PHWNSQSSMPSTPDL CCCCCCCCCCCCCCC	27.37	21743459
658	Phosphorylation	NSQSSMPSTPDLRVR CCCCCCCCCCCCCCC	43.88	23984901
659	Phosphorylation	SQSSMPSTPDLRVRS CCCCCCCCCCCCCCC	18.23	21743459
666	Phosphorylation	TPDLRVRSPHYVHST CCCCCCCCCCCCCCC	17.11	25266776
669	Phosphorylation	LRVRSPHYVHSTRSV CCCCCCCCCCCCCCE	11.84	28066266
672	Phosphorylation	RSPHYVHSTRSVDIS CCCCCCCCCCCEECC	18.57	28066266
675	Phosphorylation	HYVHSTRSVDISPTR CCCCCCCCEECCCHH	24.99	27087446
679	Phosphorylation	STRSVDISPTRLHSL CCCCEECCCHHHHHH	18.76	27087446
679 (in isoform 2)	Phosphorylation	-	18.76	19144319
681	Phosphorylation	RSVDISPTRLHSLAL CCEECCCHHHHHHHH	38.79	29899451
694	Phosphorylation	ALHFRHRSSSLESQG HHHHHHCCCCHHHCC	20.39	27087446
695	Phosphorylation	LHFRHRSSSLESQGK HHHHHCCCCHHHCCE	38.61	23737553
696	Phosphorylation	HFRHRSSSLESQGKL HHHHCCCCHHHCCEE	37.09	25521595
696 (in isoform 2)	Phosphorylation	-	37.09	19144319
699	Phosphorylation	HRSSSLESQGKLLGS HCCCCHHHCCEECCC	49.91	27087446
706	Phosphorylation	SQGKLLGSENDTGSP HCCEECCCCCCCCCC	32.94	21743459
710	Phosphorylation	LLGSENDTGSPDFYT ECCCCCCCCCCCCCC	51.66	25521595
712	Phosphorylation	GSENDTGSPDFYTPR CCCCCCCCCCCCCCC	24.32	27087446
717	Phosphorylation	TGSPDFYTPRTRSSN CCCCCCCCCCCCCCC	13.29	21743459
753	Phosphorylation	PAQMNANYSTLAEDS CCCCCCCHHHHCCCC	10.71	-
780	Phosphorylation	RAAGALGSASSGSMP HHHHHHHCCCCCCCC	26.31	25619855
782	Phosphorylation	AGALGSASSGSMPNL HHHHHCCCCCCCCCH	36.61	25521595
783	Phosphorylation	GALGSASSGSMPNLA HHHHCCCCCCCCCHH	34.30	25521595
785	Phosphorylation	LGSASSGSMPNLAAR HHCCCCCCCCCHHHH	32.77	25521595
808	Phosphorylation	GVYLHSQSQPSSQYR CEEEECCCCCCCCEE	47.26	21183079
811	Phosphorylation	LHSQSQPSSQYRIKE EECCCCCCCCEEEEE	23.57	21082442
812	Phosphorylation	HSQSQPSSQYRIKEY ECCCCCCCCEEEEEC	37.60	29899451
819	Phosphorylation	SQYRIKEYPLYIEGS CCEEEEECCEEEECC	8.11	29514104
834	Phosphorylation	ATPVVVRSLESDQEG CCCEEEEECCCCCCC	25.53	28066266
837	Phosphorylation	VVVRSLESDQEGHYS EEEEECCCCCCCCEE	50.30	25367039
843	Phosphorylation	ESDQEGHYSVKAQFK CCCCCCCEEEEEEEE	26.47	29514104
844	Phosphorylation	SDQEGHYSVKAQFKT CCCCCCEEEEEEEEC	16.09	25367039
851	Phosphorylation	SVKAQFKTSNSYTAG EEEEEEECCCCEECC	34.13	29899451
852	Phosphorylation	VKAQFKTSNSYTAGG EEEEEECCCCEECCC	25.11	28066266
854	Phosphorylation	AQFKTSNSYTAGGLF EEEECCCCEECCCCE	24.51	30372032
855	Phosphorylation	QFKTSNSYTAGGLFK EEECCCCEECCCCEE	12.59	28066266
856	Phosphorylation	FKTSNSYTAGGLFKE EECCCCEECCCCEEC	20.74	28725479
878	Phosphorylation	EGDAGRLTPSRSQIL CCCCCCCCCCHHHHC	20.18	24899341
880	Phosphorylation	DAGRLTPSRSQILRT CCCCCCCCHHHHCCC	39.05	25367039
882	Phosphorylation	GRLTPSRSQILRTPS CCCCCCHHHHCCCCC	26.38	26824392
887	Phosphorylation	SRSQILRTPSLGRDG CHHHHCCCCCCCCCC	17.49	25619855
889	Phosphorylation	SQILRTPSLGRDGAH HHHCCCCCCCCCCCC	42.73	25619855
927	Phosphorylation	HKEHSRLSHTSSTSS CHHHCCCCCCCCCCC	24.49	23984901
929	Phosphorylation	EHSRLSHTSSTSSDS HHCCCCCCCCCCCCC	22.46	23984901
930	Phosphorylation	HSRLSHTSSTSSDSG HCCCCCCCCCCCCCC	26.62	23984901
931	Phosphorylation	SRLSHTSSTSSDSGS CCCCCCCCCCCCCCC	33.20	25777480
932	Phosphorylation	RLSHTSSTSSDSGSQ CCCCCCCCCCCCCCC	31.83	23984901
933	Phosphorylation	LSHTSSTSSDSGSQY CCCCCCCCCCCCCCC	33.81	25777480
934	Phosphorylation	SHTSSTSSDSGSQYS CCCCCCCCCCCCCCC	35.56	25777480
936	Phosphorylation	TSSTSSDSGSQYSTS CCCCCCCCCCCCCCC	42.14	25777480
938	Phosphorylation	STSSDSGSQYSTSSQ CCCCCCCCCCCCCCC	29.87	25777480
940	Phosphorylation	SSDSGSQYSTSSQST CCCCCCCCCCCCCCE	18.66	25777480
941	Phosphorylation	SDSGSQYSTSSQSTF CCCCCCCCCCCCCEE	17.74	25777480
942	Phosphorylation	DSGSQYSTSSQSTFV CCCCCCCCCCCCEEE	27.71	25777480
943	Phosphorylation	SGSQYSTSSQSTFVA CCCCCCCCCCCEEEE	22.05	25777480
944	Phosphorylation	GSQYSTSSQSTFVAH CCCCCCCCCCEEEEC	28.39	25777480
946	Phosphorylation	QYSTSSQSTFVAHSR CCCCCCCCEEEECCC	26.26	25777480
947	Phosphorylation	YSTSSQSTFVAHSRV CCCCCCCEEEECCCC	17.94	25777480
952	Phosphorylation	QSTFVAHSRVTRMPQ CCEEEECCCCCCCHH	20.78	25777480
965	Phosphorylation	PQMCKATSAALPQSQ HHHHHHHHHCCCHHH	19.19	29514104
974	Phosphorylation	ALPQSQRSSTPSSEI CCCHHHHCCCCHHHC	30.81	-
975	Phosphorylation	LPQSQRSSTPSSEIG CCHHHHCCCCHHHCC	46.67	-
978	Phosphorylation	SQRSSTPSSEIGATP HHHCCCCHHHCCCCC	40.46	-
987	Phosphorylation	EIGATPPSSPHHILT HCCCCCCCCCCCEEE	58.67	-
988	Phosphorylation	IGATPPSSPHHILTW CCCCCCCCCCCEEEE	33.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRM4A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRM4A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRM4A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FRM4A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-679, AND MASSSPECTROMETRY.
PubMed: 19144319

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-785, AND MASSSPECTROMETRY.
PubMed: 15345747