KLC4_MOUSE - dbPTM
KLC4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLC4_MOUSE
UniProt AC Q9DBS5
Protein Name Kinesin light chain 4
Gene Name Klc4
Organism Mus musculus (Mouse).
Sequence Length 619
Subcellular Localization Cytoplasm, cytoskeleton .
Protein Description Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity)..
Protein Sequence MSGLVLGQRDEPAGHRLSQEEILGSTKVVSQGLEALHSEHQAVLQSLSHTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFLRQLRQYDEDGHGMEEKEGEATKDSLDDLFPNEEEEDSGNDLSRGQGAAAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTDHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYESQLGPDNPNVARTKNNLASCYLKQGKYSEAEALYKEILTCAHVQEFGSVDDDHKPIWMHAEEREEMSRSRPRDSSAPYAEYGGWYKACRVSSPTVNTTLKNLGALYRRQGKLEAAETLEECALRSRKQGTDPISQTKVAELLGEGDGRKAIQEGPGDSVKFEGGEDASVAVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSSMKRAASLNYLNQPNAAPLQVSRGLSASTVDLSSSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGLVLGQR
------CCCCCCCCC		40.61-
171PhosphorylationEEKEGEATKDSLDDL
CCCCCCCCCCCHHHH		30.9629899451
174PhosphorylationEGEATKDSLDDLFPN
CCCCCCCCHHHHCCC		34.9425521595
307UbiquitinationNLAVLYGKRGKYKEA
HHHHHHCCCCCCCCC		44.41-
449PhosphorylationSSAPYAEYGGWYKAC
CCCCCHHHCCCEEEE		16.8725367039
459PhosphorylationWYKACRVSSPTVNTT
CEEEECCCCCCHHHH		15.9625619855
460PhosphorylationYKACRVSSPTVNTTL
EEEECCCCCCHHHHH		23.0225521595
462PhosphorylationACRVSSPTVNTTLKN
EECCCCCCHHHHHHH		28.4725619855
465PhosphorylationVSSPTVNTTLKNLGA
CCCCCHHHHHHHHHH		29.2125619855
466PhosphorylationSSPTVNTTLKNLGAL
CCCCHHHHHHHHHHH		30.4525619855
542PhosphorylationASVAVEWSGDGSGTL
CEEEEEECCCCCCEE		17.3226643407
546PhosphorylationVEWSGDGSGTLQRSG
EEECCCCCCEEEECC		33.0926643407
548PhosphorylationWSGDGSGTLQRSGSL
ECCCCCCEEEECCCH		22.7826643407
552PhosphorylationGSGTLQRSGSLGKIR
CCCEEEECCCHHHHH		21.5526643407
554PhosphorylationGTLQRSGSLGKIRDV
CEEEECCCHHHHHHH		34.8829895711
565PhosphorylationIRDVLRRSSELLVRK
HHHHHHHCHHHHHHH		23.0225521595
566PhosphorylationRDVLRRSSELLVRKL
HHHHHHCHHHHHHHH		30.3826824392
581PhosphorylationQGTEPRPSSSSMKRA
CCCCCCCCCHHHHHH		44.10-
582PhosphorylationGTEPRPSSSSMKRAA
CCCCCCCCHHHHHHH		29.16-
584PhosphorylationEPRPSSSSMKRAASL
CCCCCCHHHHHHHHC		30.2129514104
590PhosphorylationSSMKRAASLNYLNQP
HHHHHHHHCCCCCCC		19.0327087446
593PhosphorylationKRAASLNYLNQPNAA
HHHHHCCCCCCCCCC		16.6025521595
605PhosphorylationNAAPLQVSRGLSAST
CCCCCCCCCCCCCCE		13.9925619855
609PhosphorylationLQVSRGLSASTVDLS
CCCCCCCCCCEECCC		24.0123527152
611PhosphorylationVSRGLSASTVDLSSS
CCCCCCCCEECCCCC		26.1125521595
612PhosphorylationSRGLSASTVDLSSSS
CCCCCCCEECCCCCC		20.1125521595
616PhosphorylationSASTVDLSSSS----
CCCEECCCCCC----		24.5825619855
617PhosphorylationASTVDLSSSS-----
CCEECCCCCC-----		41.7325619855
618PhosphorylationSTVDLSSSS------
CEECCCCCC------		36.3725619855
619PhosphorylationTVDLSSSS-------
EECCCCCC-------		46.3025619855
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLC4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLC4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLC4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KINH_HUMANKIF5Bphysical
26496610
KLC1_HUMANKLC1physical
26496610
TMCO1_HUMANTMCO1physical
26496610
UBFD1_HUMANUBFD1physical
26496610
KLC2_HUMANKLC2physical
26496610
TJAP1_HUMANTJAP1physical
26496610
KLC3_HUMANKLC3physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLC4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-590, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-566 ANDSER-590, AND MASS SPECTROMETRY.

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