TRI32_MOUSE - dbPTM
TRI32_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRI32_MOUSE
UniProt AC Q8CH72
Protein Name E3 ubiquitin-protein ligase TRIM32
Gene Name Trim32
Organism Mus musculus (Mouse).
Sequence Length 655
Subcellular Localization Cytoplasm . Localized in cytoplasmic bodies, usually concentrated around the nucleus.
Protein Description Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha..
Protein Sequence MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRGCGRRLPRQFCRSCGVVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELTGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRIQEELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAGEEGAASSASASVTFREMDMSPEEVAPSPRASPAKQRSSEAASGIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTMDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAAAAAASHLNLDAL
CHHHHHHHCCCHHHH		24.6322817900
72PhosphorylationCSKITRITSLTQLTD
HHHHHHHCCHHCCCC		17.8829899451
73PhosphorylationSKITRITSLTQLTDN
HHHHHHCCHHCCCCC		27.3529899451
205UbiquitinationEELARSRKFFTGSLA
HHHHHHCCCHHCCHH		46.18-
208PhosphorylationARSRKFFTGSLAEVE
HHHCCCHHCCHHHHH		29.0623737553
210PhosphorylationSRKFFTGSLAEVEKS
HCCCHHCCHHHHHHH		22.7323737553
258PhosphorylationDVALLEETADEEEPE
CHHHHHCCCCCCCCC		29.9929514104
269PhosphorylationEEPELTASLPRELTL
CCCCHHHCCCCEEEH		33.4025338131
330PhosphorylationTFREMDMSPEEVAPS
EEEECCCCHHHCCCC		25.5425521595
337PhosphorylationSPEEVAPSPRASPAK
CHHHCCCCCCCCCCH		19.7925521595
341PhosphorylationVAPSPRASPAKQRSS
CCCCCCCCCCHHCCH		27.0325521595
347PhosphorylationASPAKQRSSEAASGI
CCCCHHCCHHHHHHH		30.0025521595
348PhosphorylationSPAKQRSSEAASGIQ
CCCHHCCHHHHHHHH		33.1829514104
361UbiquitinationIQQCLFLKKMGAKGS
HHHHHHHHHCCCCCC		33.12-
407UbiquitinationFNRKGFLKEIRRSPS
ECCCCHHHHHHCCCC		49.16-
453PhosphorylationVTDSYDNSLKVYTMD
ECCCCCCCEEEEEEC		27.0327149854
473UbiquitinationCHRSQLSKPWGITAL
ECHHHCCCCCCCEEC		54.07-
508UbiquitinationDRGAGVVKYSCLCSA
ECCCCEEEEEEEECC		29.10-
568PhosphorylationGQLGRQISHFFSENE
CHHHHHHHHHCCCCC		13.1025338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseTrim32Q8CH72
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRI32_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRI32_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYC_MOUSEMycphysical
19269368
AGO1_MOUSEAgo1physical
19269368
PIAS4_MOUSEPias4physical
16816390
PIAS1_MOUSEPias1physical
16816390
PIAS2_MOUSEPias2physical
16816390
TRI32_MOUSETrim32physical
16243356
ACTA_RABITACTA2physical
16243356
1433T_MOUSEYwhaqphysical
23444366
NSF_HUMANNSFphysical
26496610
UBC9_HUMANUBE2Iphysical
26496610
KIF14_HUMANKIF14physical
26496610
PRDX5_HUMANPRDX5physical
26496610
LAMA1_HUMANLAMA1physical
26496610
ACTS_MOUSEActa1physical
22908310
ACTN3_MOUSEActn3physical
22908310
TPM1_MOUSETpm1physical
22908310
DESM_MOUSEDesphysical
22908310
MLRS_MOUSEMylpfphysical
22908310
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRI32_MOUSE

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Related Literatures of Post-Translational Modification

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