ACTN3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTN3_MOUSE
• UniProt AC: O88990
• Protein Name: Alpha-actinin-3
• Gene Name: Actn3
• Organism: Mus musculus (Mouse).
• Sequence Length: 900
• Protein Description: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)..
• Protein Sequence: MMMVMQPEGLGAGEGPFSGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRVQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFQQKASLHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAIEDLQDVWLVHSVEETQSLLTAHEQFKATLPEADRERGAILGIQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQGKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKSNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGDKNYITPEELRRELPAEQAEYCIRRMAPYKGSGAPSGALDYVAFSSALYGESDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMMVMQPE -------CCCCCCCC	3.36	-
44	Ubiquitination	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	27667366
48	Acetylation	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	22826441
48	Ubiquitination	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	-
48	Malonylation	AWEKQQRKTFTAWCN HHHHHHHHHHHHHHH	43.59	26320211
51	Phosphorylation	KQQRKTFTAWCNSHL HHHHHHHHHHHHHHH	25.20	28542873
56	Phosphorylation	TFTAWCNSHLRKAGT HHHHHHHHHHHHHCH	22.29	28542873
60	Ubiquitination	WCNSHLRKAGTQIEN HHHHHHHHHCHHHHC	58.49	-
63	Phosphorylation	SHLRKAGTQIENIEE HHHHHHCHHHHCHHH	31.10	22210690
95	Ubiquitination	ERLPRPDKGKMRFHK CCCCCCCCCCCCHHH	64.21	-
97	Ubiquitination	LPRPDKGKMRFHKIA CCCCCCCCCCHHHCC	32.42	-
102	Ubiquitination	KGKMRFHKIANVNKA CCCCCHHHCCCHHHH	40.58	-
108	Ubiquitination	HKIANVNKALDFIAS HHCCCHHHHHHHHHH	46.15	22790023
115	Phosphorylation	KALDFIASKGVKLVS HHHHHHHHCCCEEEE	25.73	28542873
116	Acetylation	ALDFIASKGVKLVSI HHHHHHHCCCEEEEE	59.71	23806337
116	Succinylation	ALDFIASKGVKLVSI HHHHHHHCCCEEEEE	59.71	23806337
153	Phosphorylation	RFAIQDISVEETSAK HHHHHCCCCCCCCHH	31.59	26824392
157	Phosphorylation	QDISVEETSAKEGLL HCCCCCCCCHHHCCH	22.07	27742792
158	Phosphorylation	DISVEETSAKEGLLL CCCCCCCCHHHCCHH	40.39	27742792
184	Phosphorylation	VNVQNFHTSWKDGLA CCCCCCCCCHHHHHH	31.95	28464351
185	Phosphorylation	NVQNFHTSWKDGLAL CCCCCCCCHHHHHHH	24.45	28542873
211	Ubiquitination	IDYAKLRKDDPIGNL HCHHHHCCCCCCCCH	76.54	22790023
220	Phosphorylation	DPIGNLNTAFEVAEK CCCCCHHHHHHHHHH	35.57	28464351
228	Phosphorylation	AFEVAEKYLDIPKML HHHHHHHHCCCCCCC	10.91	22817900
243	Phosphorylation	DAEDIVNTPKPDEKA CHHHHCCCCCCCHHH	23.07	28464351
277	Acetylation	TAANRICKVLAVNQE HHHHHHHHHHHHCHH	37.60	22826441
277	Ubiquitination	TAANRICKVLAVNQE HHHHHHHHHHHHCHH	37.60	22790023
287	Ubiquitination	AVNQENEKLMEEYEK HHCHHHHHHHHHHHH	65.79	22790023
292	Nitration	NEKLMEEYEKLASEL HHHHHHHHHHHHHHH	12.69	-
297	Phosphorylation	EEYEKLASELLEWIR HHHHHHHHHHHHHHH	38.93	73665989
306	Phosphorylation	LLEWIRRTVPWLENR HHHHHHHHHHHHHCC	22.52	28542873
318	Phosphorylation	ENRVGEPSMSAMQRK HCCCCCCCHHHHHHH	22.52	28542873
320	Phosphorylation	RVGEPSMSAMQRKLE CCCCCCHHHHHHHHH	25.56	28464351
325	Ubiquitination	SMSAMQRKLEDFRDY CHHHHHHHHHHHHHH	39.06	-
344	Ubiquitination	KPPRVQEKCQLEINF CCCCHHHHEEEEEEC	15.36	-
353	Phosphorylation	QLEINFNTLQTKLRL EEEEECCHHHHHHHH	18.99	28464351
356	Phosphorylation	INFNTLQTKLRLSHR EECCHHHHHHHHHCC	34.85	28464351
361	Phosphorylation	LQTKLRLSHRPAFMP HHHHHHHHCCCCCCC	15.83	28542873
369	Phosphorylation	HRPAFMPSEGKLVSD CCCCCCCCCCCCHHH	47.39	24899341
375	Phosphorylation	PSEGKLVSDIANAWR CCCCCCHHHHHHHHH	33.46	22210690
397	Phosphorylation	GYEDWLLSEIRRLQR HHHHHHHHHHHHHHH	28.89	22210690
411	Ubiquitination	RLQHLAEKFQQKASL HHHHHHHHHHHHHHH	42.75	22790023
415	Ubiquitination	LAEKFQQKASLHEAW HHHHHHHHHHHHHHH	29.20	22790023
417	Phosphorylation	EKFQQKASLHEAWTR HHHHHHHHHHHHHHH	36.98	73665975
426	Ubiquitination	HEAWTRGKEEMLNQH HHHHHHCHHHHHHCC	47.40	22790023
435	Phosphorylation	EMLNQHDYESASLQE HHHHCCCHHHCCHHH	15.06	22210690
437	Phosphorylation	LNQHDYESASLQEVR HHCCCHHHCCHHHHH	19.54	28464351
439	Phosphorylation	QHDYESASLQEVRAL CCCHHHCCHHHHHHH	39.60	22210690
455	Phosphorylation	RRHEAFESDLAAHQD HHHHHHHHHHHHCHH	31.32	51458209
479	Phosphorylation	QELNELDYHEAASVN HHHHHCCHHHHHCCH	17.74	28542873
484	Phosphorylation	LDYHEAASVNSRCQA CCHHHHHCCHHHHHH	28.95	28464351
501	Phosphorylation	DQWDNLGTLTQKRRD HCCCCHHHHHHHHHH	29.78	28542873
601	Phosphorylation	TYGLRPKSGNPYITL HHCCCCCCCCCCEEE	46.62	28542873
607	Phosphorylation	KSGNPYITLSSQDIN CCCCCCEEECHHHCC	18.10	28464351
609	Phosphorylation	GNPYITLSSQDINNK CCCCEEECHHHCCCC	19.80	28542873
610	Phosphorylation	NPYITLSSQDINNKW CCCEEECHHHCCCCH	34.68	28464351
616	Ubiquitination	SSQDINNKWDTVRKL CHHHCCCCHHHHHHH	41.79	22790023
622	Ubiquitination	NKWDTVRKLVPSRDQ CCHHHHHHHCCCCCH	49.88	22790023
626	Phosphorylation	TVRKLVPSRDQTLQE HHHHHCCCCCHHHHH	40.80	28464351
630	Phosphorylation	LVPSRDQTLQEELAR HCCCCCHHHHHHHHH	34.40	28542873
676	Phosphorylation	LAAGLAGSLEEQMAG HHHHHHCCHHHHHHH	27.31	28464351
694	Phosphorylation	QEQNIINYKSNIDRL HHHHHHHHHHHHHHH	12.84	28464351
696	Phosphorylation	QNIINYKSNIDRLEG HHHHHHHHHHHHHHC	28.76	22210690
711	Phosphorylation	DHQLLQESLVFDNKH CHHHHHHHHCCCCCC	19.51	51458201
721	Phosphorylation	FDNKHTVYSMEHIRV CCCCCCEEEHHHHHC	11.94	28464351
722	Phosphorylation	DNKHTVYSMEHIRVG CCCCCEEEHHHHHCC	17.23	28464351
736	Phosphorylation	GWEQLLTSIARTINE CHHHHHHHHHHHHHH	17.77	28542873
750	Phosphorylation	EVENQVLTRDAKGLS HHHHHHHCCCCCCCC	27.87	28464351
754	Acetylation	QVLTRDAKGLSQEQL HHHCCCCCCCCHHHH	65.75	19862925
754	Ubiquitination	QVLTRDAKGLSQEQL HHHCCCCCCCCHHHH	65.75	22790023
757	Phosphorylation	TRDAKGLSQEQLNEF CCCCCCCCHHHHHHH	40.10	28464351
767	Phosphorylation	QLNEFRASFNHFDRK HHHHHHHHHHHHHHH	23.48	24899341
857	Methylation	YITPEELRRELPAEQ CCCHHHHHHHCCHHH	33.05	-
858	Methylation	ITPEELRRELPAEQA CCHHHHHHHCCHHHH	63.53	-
875	Phosphorylation	CIRRMAPYKGSGAPS HHHHHCCCCCCCCCC	20.60	51458177
898	Phosphorylation	SSALYGESDL----- HHHHHCCCCC-----	39.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTN3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTN3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTN3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTN3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.