MLRS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLRS_MOUSE
• UniProt AC: P97457
• Protein Name: Myosin regulatory light chain 2, skeletal muscle isoform
• Gene Name: Mylpf
• Organism: Mus musculus (Mouse).
• Sequence Length: 169
• Protein Sequence: MAPKKAKRRAGAEGSSNVFSMFDQTQIQEFKEAFTVIDQNRDGIIDKEDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITGAFKVLDPEGKGTIKKQFLEELLTTQCDRFSQEEIKNMWAAFPPDVGGNVDYKNICYVITHGDAKDQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPKKAKRR ------CCCHHHHHH	25.31	-
15	Phosphorylation	RRAGAEGSSNVFSMF HHHCCCCCCCHHHCC	15.39	25521595
16	Phosphorylation	RAGAEGSSNVFSMFD HHCCCCCCCHHHCCC	48.12	25521595
20	Phosphorylation	EGSSNVFSMFDQTQI CCCCCHHHCCCHHHH	17.79	25521595
25	Phosphorylation	VFSMFDQTQIQEFKE HHHCCCHHHHHHHHH	29.50	23737553
31	Acetylation	QTQIQEFKEAFTVID HHHHHHHHHHHHHHC	47.59	19863181
31	Ubiquitination	QTQIQEFKEAFTVID HHHHHHHHHHHHHHC	47.59	-
35	Phosphorylation	QEFKEAFTVIDQNRD HHHHHHHHHHCCCCC	24.49	28464351
47	Acetylation	NRDGIIDKEDLRDTF CCCCCCCHHHHHHHH	42.60	21728379
47	Ubiquitination	NRDGIIDKEDLRDTF CCCCCCCHHHHHHHH	42.60	22790023
53	Phosphorylation	DKEDLRDTFAAMGRL CHHHHHHHHHHHCCC	14.56	24899341
63	Ubiquitination	AMGRLNVKNEELDAM HHCCCCCCHHHHHHH	58.53	22790023
63	Acetylation	AMGRLNVKNEELDAM HHCCCCCCHHHHHHH	58.53	21728379
75	Phosphorylation	DAMMKEASGPINFTV HHHHHHCCCCEEEEE	46.31	22210690
81	Phosphorylation	ASGPINFTVFLTMFG CCCCEEEEEEEHHHH	13.08	22210690
85	Phosphorylation	INFTVFLTMFGEKLK EEEEEEEHHHHHHHC	10.05	22210690
92	Ubiquitination	TMFGEKLKGADPEDV HHHHHHHCCCCHHHH	64.22	22790023
92	Acetylation	TMFGEKLKGADPEDV HHHHHHHCCCCHHHH	64.22	21728379
101	Phosphorylation	ADPEDVITGAFKVLD CCHHHHHCCEEEEEC	23.47	28464351
105	Ubiquitination	DVITGAFKVLDPEGK HHHCCEEEEECCCCC	41.16	22790023
105	Acetylation	DVITGAFKVLDPEGK HHHCCEEEEECCCCC	41.16	21728379
112	Acetylation	KVLDPEGKGTIKKQF EEECCCCCCCHHHHH	51.74	21728379
112	Ubiquitination	KVLDPEGKGTIKKQF EEECCCCCCCHHHHH	51.74	22790023
116	Ubiquitination	PEGKGTIKKQFLEEL CCCCCCHHHHHHHHH	40.12	22790023
117	Ubiquitination	EGKGTIKKQFLEELL CCCCCHHHHHHHHHH	42.29	22790023
126	Phosphorylation	FLEELLTTQCDRFSQ HHHHHHHHCCHHCCH	27.46	28542873
132	Phosphorylation	TTQCDRFSQEEIKNM HHCCHHCCHHHHHHH	37.26	22210690
137	Ubiquitination	RFSQEEIKNMWAAFP HCCHHHHHHHHHHCC	43.99	-
154	Acetylation	VGGNVDYKNICYVIT CCCCCCCCCEEEEEE	35.06	19863197
158	Phosphorylation	VDYKNICYVITHGDA CCCCCEEEEEECCCC	7.35	28542873
161	Phosphorylation	KNICYVITHGDAKDQ CCEEEEEECCCCCCC	15.12	22210690
166	Acetylation	VITHGDAKDQE---- EEECCCCCCCC----	65.76	21728379
166	Ubiquitination	VITHGDAKDQE---- EEECCCCCCCC----	65.76	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Trim63	Q38HM4	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLRS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLRS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MLRS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 17242355