AGO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGO1_MOUSE
• UniProt AC: Q8CJG1
• Protein Name: Protein argonaute-1
• Gene Name: Ago1
• Organism: Mus musculus (Mouse).
• Sequence Length: 857
• Subcellular Localization: Cytoplasm, P-body.
• Protein Description: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)..
• Protein Sequence: MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
477	Ubiquitination	DQLRKISKDAGMPIQ HHHHHHHHHCCCCCC	55.88	-
552	Ubiquitination	VQVKNVVKTSPQTLS EEEEEEECCCHHHHH	38.72	-
652	Phosphorylation	RELLIQFYKSTRFKP HHHHHHHHHHCCCCC	6.40	-
696	Phosphorylation	CIKLEKDYQPGITYI HHHHHCCCCCCEEEE	27.89	51458713
822	Phosphorylation	LVDKEHDSGEGSHIS EECCCCCCCCCCCCC	40.42	37817091
826	Phosphorylation	EHDSGEGSHISGQSN CCCCCCCCCCCCCCC	17.22	26060331
829	Phosphorylation	SGEGSHISGQSNGRD CCCCCCCCCCCCCCC	25.92	26060331

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI32_MOUSE	Trim32	physical	19269368

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.