1433T_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433T_MOUSE
• UniProt AC: P68254
• Protein Name: 14-3-3 protein theta
• Gene Name: Ywhaq
• Organism: Mus musculus (Mouse).
• Sequence Length: 245
• Subcellular Localization: Cytoplasm.
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)..
• Protein Sequence: MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKTELIQ -------CCHHHHHH	12.29	-
3	Acetylation	-----MEKTELIQKA -----CCHHHHHHHH	46.10	7610725
4	Phosphorylation	----MEKTELIQKAK ----CCHHHHHHHHH	23.79	29514104
9	Ubiquitination	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	-
9	Acetylation	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	22826441
9	Malonylation	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	26320211
11	Ubiquitination	TELIQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	-
25	S-nitrosocysteine	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	-
25	Glutathionylation	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	24333276
25	S-nitrosylation	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	24926564
37	Phosphorylation	TEQGAELSNEERNLL HHHHHHCCHHHHHHH	33.43	26525534
45	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHCHH	14.10	26824392
48	Phosphorylation	RNLLSVAYKNVVGGR HHHHHHHHHCHHCCC	10.84	20415495
49	Acetylation	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	22826441
49	Ubiquitination	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	-
63	Phosphorylation	RSAWRVISSIEQKTD HHHHHHHHHHHHCCC	23.54	63771845
64	Phosphorylation	SAWRVISSIEQKTDT HHHHHHHHHHHCCCC	21.01	25521595
68	Ubiquitination	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	-
68	Malonylation	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	26320211
68	Acetylation	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	-
71	Phosphorylation	SIEQKTDTSDKKLQL HHHHCCCCCHHHHHH	44.02	25338131
74	Ubiquitination	QKTDTSDKKLQLIKD HCCCCCHHHHHHHHH	55.97	-
80	Acetylation	DKKLQLIKDYREKVE HHHHHHHHHHHHHHH	58.25	22826441
80	Ubiquitination	DKKLQLIKDYREKVE HHHHHHHHHHHHHHH	58.25	-
82	Nitration	KLQLIKDYREKVESE HHHHHHHHHHHHHHH	18.70	-
85	Ubiquitination	LIKDYREKVESELRS HHHHHHHHHHHHHHH	42.16	-
88	Phosphorylation	DYREKVESELRSICT HHHHHHHHHHHHHHH	44.94	101544615
92	Phosphorylation	KVESELRSICTTVLE HHHHHHHHHHHHHHH	34.34	22817900
94	Glutathionylation	ESELRSICTTVLELL HHHHHHHHHHHHHHH	2.48	24333276
94	S-nitrosylation	ESELRSICTTVLELL HHHHHHHHHHHHHHH	2.48	22588120
94	S-palmitoylation	ESELRSICTTVLELL HHHHHHHHHHHHHHH	2.48	28526873
104	Nitration	VLELLDKYLIANATN HHHHHHHHHHHCCCC	11.74	-
110	Phosphorylation	KYLIANATNPESKVF HHHHHCCCCCCCCEE	51.63	22817900
114	Phosphorylation	ANATNPESKVFYLKM HCCCCCCCCEEEEEE	35.06	29899451
115	Acetylation	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	23236377
115	Ubiquitination	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	-
120	Acetylation	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	21728379
120	Ubiquitination	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	-
122	Acetylation	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	22826441
122	Ubiquitination	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	-
128	Phosphorylation	MKGDYFRYLAEVACG ECCCHHHHHHHHHCC	10.60	29899451
134	S-nitrosylation	RYLAEVACGDDRKQT HHHHHHHCCCCHHHH	8.09	19101475
134	Glutathionylation	RYLAEVACGDDRKQT HHHHHHHCCCCHHHH	8.09	24333276
134	S-nitrosocysteine	RYLAEVACGDDRKQT HHHHHHHCCCCHHHH	8.09	-
139	Ubiquitination	VACGDDRKQTIENSQ HHCCCCHHHHHHHCC	59.80	-
157	Ubiquitination	QEAFDISKKEMQPTH HHHHHCCHHHCCCCC	53.76	-
158	Ubiquitination	EAFDISKKEMQPTHP HHHHCCHHHCCCCCC	52.18	-
158	Acetylation	EAFDISKKEMQPTHP HHHHCCHHHCCCCCC	52.18	22826441
193	Ubiquitination	ELACTLAKTAFDEAI HHHHHHHHHHHHHHH	43.42	-
194	Phosphorylation	LACTLAKTAFDEAIA HHHHHHHHHHHHHHH	27.27	26239621
205	Phosphorylation	EAIAELDTLNEDSYK HHHHHHHCCCCCCCC	44.07	26239621
210	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	25195567
214	Phosphorylation	NEDSYKDSTLIMQLL CCCCCCCHHHHHHHH	22.44	28066266
215	Phosphorylation	EDSYKDSTLIMQLLR CCCCCCHHHHHHHHH	30.36	28066266
226	Phosphorylation	QLLRDNLTLWTSDSA HHHHCCCEEEECCCC	26.89	24925903
229	Phosphorylation	RDNLTLWTSDSAGEE HCCCEEEECCCCCCC	26.26	24925903
230	Phosphorylation	DNLTLWTSDSAGEEC CCCEEEECCCCCCCC	20.27	24925903
232	Phosphorylation	LTLWTSDSAGEECDA CEEEECCCCCCCCCH	37.63	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
232	S	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433T_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433T_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRRK2_MOUSE	Lrrk2	physical	21390248
LRRK2_MOUSE	Lrrk2	physical	20642453
TAU_MOUSE	Mapt	physical	19014373

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.