dbPTM

LRRK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRRK2_MOUSE
UniProt AC	Q5S006
Protein Name	Leucine-rich repeat serine/threonine-protein kinase 2
Gene Name	Lrrk2
Organism	Mus musculus (Mouse).
Sequence Length	2527
Subcellular Localization	Membrane Peripheral membrane protein. Cytoplasm. Perikaryon. Cell projection, axon. Cell projection, dendrite. Golgi apparatus . Endoplasmic reticulum . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Peripheral membrane protein Cyt
Protein Description	Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. Has GTPase activity (By similarity)..
Protein Sequence	MASGACQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEDKNFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLILKMLTVHHANVNLSIVGLKALDLLLDSGKLTLLILDEECDIFLLIFDAMHRYSANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSNVEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLFQKLTLGNFFNILVLNEVHVFVVKAVRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLFWLEPCYKALVRHRKDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAAAHALSTLLEQNVNFRKILLAKGVYLNVLELMQKHAHAPEVAESGCKMLSHLFEGSNPSLDTMAAVVPKILTVMKAHGTSLSVQLEALRAILHFVVPGLLEESREDSQCRPNVLRKQCFRTDIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLPDATETLSLQGAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTTLSILELSVSFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQNNSIMVECLLLLGADANQVKGATSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQKGDSQVISLLLRKLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLARKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSESSFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLRSSRLPSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETLKCLIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAMKCPSLKQLNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNHIPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRSLDMSHNNIECLPGPAHWKSLNLRELIFSKNQISTLDFSENPHVWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHVGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELGMQGATVGIDVRDWSIQIRGKRRKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVNEHQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLKHPKGIISRRDVEKFLSKKKRFPKNYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNLNSKSATLWLGCGNTEKGQLSLFDLNTERYSYEEVADSRILCLALVHLAAEKESWVVCGTQSGALLVINVEEETKRHTLEKMTDSVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFEDKAVKCKGAAPLKTLHIGDVSTPLMCLSESLNSSERHITWGGCGTKVFSFSNDFTIQKLIETKTNQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKLNKESKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGSLKNVMLVLGYKRKSTEGIQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADKMRKTSVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
568	Phosphorylation	KCGLKVISSLAHLPD HCCHHHHHHHHCCCC	23.45	25159016
569	Phosphorylation	CGLKVISSLAHLPDA CCHHHHHHHHCCCCC	20.60	25159016
577	Phosphorylation	LAHLPDATETLSLQG HHCCCCCCCEECHHH	36.56	25159016
579	Phosphorylation	HLPDATETLSLQGAV CCCCCCCEECHHHHH	19.79	25159016
581	Phosphorylation	PDATETLSLQGAVDS CCCCCEECHHHHHHH	26.51	25159016
588	Phosphorylation	SLQGAVDSVLHTLQM CHHHHHHHHHHHHHC	21.71	25159016
592	Phosphorylation	AVDSVLHTLQMYPDD HHHHHHHHHHCCCCC	17.96	25159016
596	Phosphorylation	VLHTLQMYPDDQEIQ HHHHHHCCCCCHHHH	7.19	25159016
615	Phosphorylation	HLMGCLMTKKNFCIG HHHHHHHCCCCEEEC	26.39	25159016
860	Phosphorylation	QEGVASGSDGKFSED HHHHHCCCCCCCCHH	40.47	-
908	Phosphorylation	SFLVKRKSNSISVGE CEEEEECCCCCCHHH	39.58	25619855
910	Phosphorylation	LVKRKSNSISVGEVY EEEECCCCCCHHHHH	24.27	25521595
912	Phosphorylation	KRKSNSISVGEVYRD EECCCCCCHHHHHHH	24.72	25619855
917	Phosphorylation	SISVGEVYRDLALQR CCCHHHHHHHHHHHH	8.29	25619855
933	Phosphorylation	SPNAQRHSNSLGPVF CCCHHHHCCCCCCCC	30.24	25521595
935	Phosphorylation	NAQRHSNSLGPVFDH CHHHHCCCCCCCCCH	37.40	26824392
954	Phosphorylation	RRKRKILSSDESLRS HHHHHHCCCCHHHHH	38.94	29233185
955	Phosphorylation	RKRKILSSDESLRSS HHHHHCCCCHHHHHC	41.79	26824392
958	Phosphorylation	KILSSDESLRSSRLP HHCCCCHHHHHCCCC	33.79	29233185
971	Phosphorylation	LPSHMRQSDSSSSLA CCHHHCCCCCCCCHH	29.15	25338131
973	Phosphorylation	SHMRQSDSSSSLASE HHHCCCCCCCCHHHH	37.05	25521595
974	Phosphorylation	HMRQSDSSSSLASER HHCCCCCCCCHHHHH	29.01	29899451
975	Phosphorylation	MRQSDSSSSLASERE HCCCCCCCCHHHHHH	33.07	29514104
976	Phosphorylation	RQSDSSSSLASEREH CCCCCCCCHHHHHHH	29.87	22817900
979	Phosphorylation	DSSSSLASEREHITS CCCCCHHHHHHHHHH	42.34	29899451
986	Phosphorylation	SEREHITSLDLSANE HHHHHHHHCCCCHHH	21.20	29899451
1292	Phosphorylation	PNEMGKLSKIWDLPL CCCCCCCHHHCCCCC	26.11	-
1444	Phosphorylation	NIKARASSSPVILVG HHHHCCCCCCEEEEE	37.36	28576409
1716	Phosphorylation	INRLLEISPFMLSGR HHHHHHHCHHCCCCC	11.60	-
1721	Phosphorylation	EISPFMLSGRERALR HHCHHCCCCCHHHCC	24.82	20047950
1833	Ubiquitination	LLDELMKKAEEGDLL HHHHHHHHHHHCCCC	47.25	22790023
1963	Ubiquitination	DRLLQQDKASLTRTL HHHHHHCHHHHHHHH	35.22	22790023
2091	Ubiquitination	DELAIQGKLPDPVKE HHHHHCCCCCCCHHH	40.23	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
935	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
935	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1292	S	Phosphorylation	Kinase	LRRK2	Q5S007	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
910	S	Phosphorylation	28720718
Phosphorylation of Ser-910 and Ser-935 or Ser-1444 facilitates interaction with YWHAG (By similarity).
910	S	Phosphorylation	28720718
Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN (By similarity).
935	S	Phosphorylation	21183079
Phosphorylation of Ser-910 and Ser-935 or Ser-1444 facilitates interaction with YWHAG (By similarity).
935	S	Phosphorylation	21183079
Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN (By similarity).
1444	S	Phosphorylation	28720718
Phosphorylation of Ser-910 and Ser-935 or Ser-1444 facilitates interaction with YWHAG (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRRK2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAOK1_MOUSE	Taok1	physical	20949042
HS90A_MOUSE	Hsp90aa1	physical	18367605
CDC37_MOUSE	Cdc37	physical	18367605
ARHG7_MOUSE	Arhgef7	physical	21048939
CDC42_MOUSE	Cdc42	physical	21048939
FIS1_MOUSE	Fis1	physical	22639965
DNM1L_MOUSE	Dnm1l	physical	22639965
1433T_MOUSE	Ywhaq	physical	20659021
LRRK2_MOUSE	Lrrk2	physical	20659021
LRRK2_MOUSE	Lrrk2	physical	17623048
MBP_MOUSE	Mbp	physical	17623048
1433B_MOUSE	Ywhab	physical	21390248
1433T_MOUSE	Ywhaq	physical	21390248
1433E_MOUSE	Ywhae	physical	21390248
1433Z_MOUSE	Ywhaz	physical	21390248
1433F_MOUSE	Ywhah	physical	21390248
1433G_MOUSE	Ywhag	physical	21390248
LRRK2_MOUSE	Lrrk2	physical	21390248
CTNB1_MOUSE	Ctnnb1	physical	22899650
DVL3_MOUSE	Dvl3	physical	22899650
AXIN1_MOUSE	Axin1	physical	22899650
GSK3B_MOUSE	Gsk3b	physical	22899650
HS90A_MOUSE	Hsp90aa1	physical	20642453
1433T_MOUSE	Ywhaq	physical	20642453
HERC2_MOUSE	Herc2	physical	26355680
NEUL4_MOUSE	Neurl4	physical	26355680
WSB1_MOUSE	Wsb1	physical	27273569

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRRK2_MOUSE

Related Literatures of Post-Translational Modification

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