MBP_MOUSE - dbPTM
MBP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MBP_MOUSE
UniProt AC P04370
Protein Name Myelin basic protein
Gene Name Mbp
Organism Mus musculus (Mouse).
Sequence Length 250
Subcellular Localization Isoform 13: Myelin membrane
Peripheral membrane protein
Cytoplasmic side.
Isoform 12: Myelin membrane
Peripheral membrane protein
Cytoplasmic side.
Isoform 11: Myelin membrane
Peripheral membrane protein
Cytoplasmic side.
Isoform 10: Myelin membr
Protein Description The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function..
Protein Sequence MGNHSGKRELSAEKASKDGEIHRGEAGKKRSVGKLSQTASEDSDVFGEADAIQNNGTSAEDTAVTDSKHTADPKNNWQGAHPADPGNRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDPTAASGGLDVMASQKRPSQRSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKDSHTRTTHYGSLPQKSQHGRTQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 4)Acetylation-40.32-
2 (in isoform 5)Acetylation-40.32-
2 (in isoform 6)Acetylation-40.32-
2 (in isoform 7)Acetylation-40.32-
2 (in isoform 8)Acetylation-40.32-
2 (in isoform 9)Acetylation-40.32-
5Phosphorylation---MGNHSGKRELSA
---CCCCCCCCCCCH		50.4324719451
31PhosphorylationGEAGKKRSVGKLSQT
CCCCCCCCCCCCCCC		44.0625266776
36PhosphorylationKRSVGKLSQTASEDS
CCCCCCCCCCCCCCC		29.0419060867
38PhosphorylationSVGKLSQTASEDSDV
CCCCCCCCCCCCCCC		28.8619060867
40PhosphorylationGKLSQTASEDSDVFG
CCCCCCCCCCCCCHH		45.3727087446
43PhosphorylationSQTASEDSDVFGEAD
CCCCCCCCCCHHHHH		31.4625521595
55 (in isoform 11)Phosphorylation-38.4516452087
55 (in isoform 13)Phosphorylation-38.4516452087
55 (in isoform 4)Phosphorylation-38.4516452087
55 (in isoform 6)Phosphorylation-38.4516452087
55 (in isoform 9)Phosphorylation-38.4516452087
57PhosphorylationDAIQNNGTSAEDTAV
HHHHCCCCCHHHCEE		27.2130635358
58PhosphorylationAIQNNGTSAEDTAVT
HHHCCCCCHHHCEEC		30.9330635358
62PhosphorylationNGTSAEDTAVTDSKH
CCCCHHHCEECCCCC		17.9630635358
64 (in isoform 11)Phosphorylation-7.1121930439
64 (in isoform 13)Phosphorylation-7.1121930439
64 (in isoform 4)Phosphorylation-7.1121930439
64 (in isoform 6)Phosphorylation-7.1121930439
64 (in isoform 9)Phosphorylation-7.1121930439
66 (in isoform 11)Phosphorylation-49.4425521595
66 (in isoform 13)Phosphorylation-49.4425521595
66 (in isoform 4)Phosphorylation-49.4425521595
66 (in isoform 6)Phosphorylation-49.4425521595
66 (in isoform 9)Phosphorylation-49.4425521595
70 (in isoform 11)Phosphorylation-36.1725521595
70 (in isoform 13)Phosphorylation-36.1725521595
70 (in isoform 4)Phosphorylation-36.1725521595
70 (in isoform 6)Phosphorylation-36.1725521595
70 (in isoform 9)Phosphorylation-36.1725521595
74 (in isoform 11)Phosphorylation-64.5629899451
74 (in isoform 13)Phosphorylation-64.5629899451
74 (in isoform 4)Phosphorylation-64.5629899451
74 (in isoform 6)Phosphorylation-64.5629899451
74 (in isoform 9)Phosphorylation-64.5629899451
85 (in isoform 11)Phosphorylation-44.0329899451
85 (in isoform 13)Phosphorylation-44.0329899451
85 (in isoform 4)Phosphorylation-44.0329899451
85 (in isoform 6)Phosphorylation-44.0329899451
85 (in isoform 9)Phosphorylation-44.0329899451
93 (in isoform 5)Phosphorylation-35.7228464351
93 (in isoform 8)Phosphorylation-35.7228464351
94 (in isoform 11)Phosphorylation-3.4728464351
94 (in isoform 13)Phosphorylation-3.4728464351
94 (in isoform 4)Phosphorylation-3.4728464351
94 (in isoform 6)Phosphorylation-3.4728464351
94 (in isoform 9)Phosphorylation-3.4728464351
96PhosphorylationPHLIRLFSRDAPGRE
CCHHEEECCCCCCCC		33.5726824392
96 (in isoform 10)Phosphorylation-33.5725521595
96 (in isoform 5)Phosphorylation-33.5720047950
96 (in isoform 8)Phosphorylation-33.5720047950
106PhosphorylationAPGREDNTFKDRPSE
CCCCCCCCCCCCCCC		44.3725266776
108 (in isoform 5)Phosphorylation-51.2822324799
108 (in isoform 8)Phosphorylation-51.2822324799
110 (in isoform 5)Phosphorylation-36.9229899451
110 (in isoform 8)Phosphorylation-36.9229899451
112PhosphorylationNTFKDRPSESDELQT
CCCCCCCCCCCCHHH		51.1028833060
113 (in isoform 5)Phosphorylation-65.9625521595
113 (in isoform 8)Phosphorylation-65.9629899451
114PhosphorylationFKDRPSESDELQTIQ
CCCCCCCCCCHHHHH		40.5028833060
114 (in isoform 7)Phosphorylation-40.5018034455
119PhosphorylationSESDELQTIQEDPTA
CCCCCHHHHHCCCCH		36.9328833060
119 (in isoform 4)Phosphorylation-36.9328464351
119 (in isoform 6)Phosphorylation-36.9328464351
119 (in isoform 7)Phosphorylation-36.9323375375
119 (in isoform 8)Phosphorylation-36.9325521595
121 (in isoform 8)Phosphorylation-53.0529899451
122 (in isoform 11)Phosphorylation-63.2125521595
122 (in isoform 4)Phosphorylation-63.2120047950
122 (in isoform 6)Phosphorylation-63.2120047950
123 (in isoform 7)Phosphorylation-29.4928382018
123 (in isoform 8)Phosphorylation-29.4929899451
125PhosphorylationQTIQEDPTAASGGLD
HHHHCCCCHHHCCHH		47.3725367039
125 (in isoform 5)Phosphorylation-47.3729899451
128PhosphorylationQEDPTAASGGLDVMA
HCCCCHHHCCHHHEE		30.8125367039
130 (in isoform 10)Phosphorylation-19.0629899451
130 (in isoform 5)Phosphorylation-19.0623375375
132 (in isoform 10)Phosphorylation-31.2729899451
132 (in isoform 7)Phosphorylation-31.2725521595
134 (in isoform 4)Phosphorylation-2.7222324799
134 (in isoform 5)Phosphorylation-2.7228382018
134 (in isoform 6)Phosphorylation-2.7222324799
135 (in isoform 10)Phosphorylation-14.5225521595
136PhosphorylationGGLDVMASQKRPSQR
CCHHHEECCCCHHHH		20.3826239621
136 (in isoform 4)Phosphorylation-20.3829899451
136 (in isoform 6)Phosphorylation-20.3829899451
137 (in isoform 7)Phosphorylation-35.9225521595
138UbiquitinationLDVMASQKRPSQRSK
HHHEECCCCHHHHHH		64.87-
139 (in isoform 4)Phosphorylation-28.5925521595
139 (in isoform 6)Phosphorylation-28.5929899451
139 (in isoform 7)Phosphorylation-28.5925521595
140 (in isoform 9)Phosphorylation-41.6818034455
141PhosphorylationMASQKRPSQRSKYLA
EECCCCHHHHHHHHH		42.1126239621
143 (in isoform 5)Phosphorylation-39.1825521595
144PhosphorylationQKRPSQRSKYLATAS
CCCHHHHHHHHHHHH		20.2921930439
145AcetylationKRPSQRSKYLATAST
CCHHHHHHHHHHHHH		46.6121728379
145MethylationKRPSQRSKYLATAST
CCHHHHHHHHHHHHH		46.61-
145UbiquitinationKRPSQRSKYLATAST
CCHHHHHHHHHHHHH		46.61-
145 (in isoform 6)Phosphorylation-46.6125521595
145 (in isoform 9)Phosphorylation-46.6123375375
146PhosphorylationRPSQRSKYLATASTM
CHHHHHHHHHHHHHH		11.6525521595
147 (in isoform 10)Phosphorylation-3.8229899451
147 (in isoform 6)Phosphorylation-3.8229899451
148 (in isoform 5)Phosphorylation-9.6825521595
149PhosphorylationQRSKYLATASTMDHA
HHHHHHHHHHHHHHH		20.6722324799
149 (in isoform 6)Phosphorylation-20.6729899451
149 (in isoform 7)Phosphorylation-20.6722324799
149 (in isoform 9)Phosphorylation-20.6728382018
150 (in isoform 5)Phosphorylation-9.4425521595
151PhosphorylationSKYLATASTMDHARH
HHHHHHHHHHHHHHH		21.6525521595
151 (in isoform 4)Phosphorylation-21.6529899451
151 (in isoform 7)Phosphorylation-21.6529899451
152PhosphorylationKYLATASTMDHARHG
HHHHHHHHHHHHHHC		24.9325521595
152 (in isoform 10)Phosphorylation-24.9323375375
153 (in isoform 7)Phosphorylation-3.0925521595
156 (in isoform 10)Phosphorylation-10.8228382018
156 (in isoform 11)Phosphorylation-10.8229899451
156 (in isoform 4)Phosphorylation-10.8223375375
157CitrullinationASTMDHARHGFLPRH
HHHHHHHHHCCCCCC		27.35-
157CitrullinationASTMDHARHGFLPRH
HHHHHHHHHCCCCCC		27.35-
158 (in isoform 11)Phosphorylation-31.9422324799
158 (in isoform 9)Phosphorylation-31.9425521595
160 (in isoform 4)Phosphorylation-7.4928382018
160 (in isoform 5)Phosphorylation-7.4922324799
161 (in isoform 11)Phosphorylation-4.2829899451
162 (in isoform 5)Phosphorylation-27.9829899451
163CitrullinationARHGFLPRHRDTGIL
HHHCCCCCCCCCCCH		39.35-
163CitrullinationARHGFLPRHRDTGIL
HHHCCCCCCCCCCCH		39.35-
163 (in isoform 9)Phosphorylation-39.3525521595
164 (in isoform 5)Phosphorylation-29.9925521595
165 (in isoform 10)Phosphorylation-44.4525521595
165 (in isoform 9)Phosphorylation-44.4525521595
167PhosphorylationFLPRHRDTGILDSIG
CCCCCCCCCCHHHHH		26.5325521595
167 (in isoform 11)Phosphorylation-26.5325521595
169 (in isoform 11)Phosphorylation-4.1329899451
169 (in isoform 4)Phosphorylation-4.1325521595
170 (in isoform 10)Phosphorylation-4.4625521595
171 (in isoform 11)Phosphorylation-35.9729899451
172O-linked_GlycosylationRDTGILDSIGRFFSG
CCCCCHHHHHHHCCC		24.4041587
172PhosphorylationRDTGILDSIGRFFSG
CCCCCHHHHHHHCCC		24.4021930439
172 (in isoform 10)Phosphorylation-24.4025521595
174 (in isoform 4)Phosphorylation-25.0525521595
175MethylationGILDSIGRFFSGDRG
CCHHHHHHHCCCCCC		27.9724129315
175 (in isoform 9)Phosphorylation-27.9722324799
176 (in isoform 4)Phosphorylation-4.8825521595
177 (in isoform 9)Phosphorylation-8.4329899451
178PhosphorylationDSIGRFFSGDRGAPK
HHHHHHCCCCCCCCC		36.7522817900
179 (in isoform 9)Phosphorylation-24.3925521595
181MethylationGRFFSGDRGAPKRGS
HHHCCCCCCCCCCCC		46.8524129315
182 (in isoform 10)Phosphorylation-51.4722324799
184 (in isoform 10)Phosphorylation-29.6929899451
186 (in isoform 10)Phosphorylation-43.3725521595
186 (in isoform 4)Phosphorylation-43.3722324799
188PhosphorylationRGAPKRGSGKDSHTR
CCCCCCCCCCCCCCC		46.8622817900
188 (in isoform 2)Phosphorylation-46.8625266776
188 (in isoform 4)Phosphorylation-46.8629899451
190 (in isoform 4)Phosphorylation-58.7325521595
192PhosphorylationKRGSGKDSHTRTTHY
CCCCCCCCCCCCCCC		30.1922817900
194PhosphorylationGSGKDSHTRTTHYGS
CCCCCCCCCCCCCCC		33.3922817900
196PhosphorylationGKDSHTRTTHYGSLP
CCCCCCCCCCCCCCC		21.0522817900
197PhosphorylationKDSHTRTTHYGSLPQ
CCCCCCCCCCCCCCC		15.1525521595
199PhosphorylationSHTRTTHYGSLPQKS
CCCCCCCCCCCCCCC		13.3025521595
201O-linked_GlycosylationTRTTHYGSLPQKSQH
CCCCCCCCCCCCCCC		29.7047239
201PhosphorylationTRTTHYGSLPQKSQH
CCCCCCCCCCCCCCC		29.7025521595
205AcetylationHYGSLPQKSQHGRTQ
CCCCCCCCCCCCCCC		50.5819859443
205UbiquitinationHYGSLPQKSQHGRTQ
CCCCCCCCCCCCCCC		50.58-
206PhosphorylationYGSLPQKSQHGRTQD
CCCCCCCCCCCCCCC		23.3521930439
211O-linked_GlycosylationQKSQHGRTQDENPVV
CCCCCCCCCCCCCCE		44.99145399
211PhosphorylationQKSQHGRTQDENPVV
CCCCCCCCCCCCCCE		44.9922817900
222AcetylationNPVVHFFKNIVTPRT
CCCEEEECCCCCCCC		44.8321728379
222UbiquitinationNPVVHFFKNIVTPRT
CCCEEEECCCCCCCC		44.83-
226PhosphorylationHFFKNIVTPRTPPPS
EEECCCCCCCCCCCC		11.8524925903
229PhosphorylationKNIVTPRTPPPSQGK
CCCCCCCCCCCCCCC		41.1524925903
233PhosphorylationTPRTPPPSQGKGGRD
CCCCCCCCCCCCCCC		58.2924925903
234Deamidated glutaminePRTPPPSQGKGGRDS
CCCCCCCCCCCCCCC		64.49-
234DeamidationPRTPPPSQGKGGRDS
CCCCCCCCCCCCCCC		64.49-
239CitrullinationPSQGKGGRDSRSGSP
CCCCCCCCCCCCCCC		47.61-
239CitrullinationPSQGKGGRDSRSGSP
CCCCCCCCCCCCCCC		47.61-
241PhosphorylationQGKGGRDSRSGSPMA
CCCCCCCCCCCCCCC		27.3029899451
243PhosphorylationKGGRDSRSGSPMARR
CCCCCCCCCCCCCCC		47.8025521595
245PhosphorylationGRDSRSGSPMARR--
CCCCCCCCCCCCC--		16.8525521595
250CitrullinationSGSPMARR-------
CCCCCCCC-------		41.16-
250CitrullinationSGSPMARR-------
CCCCCCCC-------		41.16-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
245SPhosphorylationKinaseUHMK1P97343
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MBP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MBP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YES_HUMANYES1physical
18067320
DLG4_HUMANDLG4physical
18067320
PHEX_HUMANPHEXphysical
18067320
SRC8_HUMANCTTNphysical
18067320
ABL1_HUMANABL1physical
18067320
ITK_HUMANITKphysical
18067320
SRC_HUMANSRCphysical
18067320
FYN_HUMANFYNphysical
18067320
LCK_HUMANLCKphysical
18067320
HCK_HUMANHCKphysical
18067320
HCLS1_HUMANHCLS1physical
18067320
VAV_HUMANVAV1physical
18067320
NCK1_HUMANNCK1physical
18067320
NEBU_HUMANNEBphysical
18067320
RASA1_HUMANRASA1physical
18067320
ABL2_HUMANABL2physical
18067320
BLK_HUMANBLKphysical
18067320
VAV2_HUMANVAV2physical
18067320
BTK_HUMANBTKphysical
18067320
ARHG5_HUMANARHGEF5physical
18067320
ARHG7_HUMANARHGEF7physical
18067320
MPP2_HUMANMPP2physical
18067320
ITSN1_HUMANITSN1physical
18067320
STAM1_HUMANSTAMphysical
18067320
PEX13_HUMANPEX13physical
18067320
P85B_HUMANPIK3R2physical
18067320
FYB1_HUMANFYBphysical
18067320
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MBP_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND MASSSPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.
"Quantitative analysis of both protein expression and serine /threonine post-translational modifications through stable isotopelabeling with dithiothreitol.";
Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L.,Hart G.W., Burlingame A.L.;
Proteomics 5:388-398(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-178, ANDMASS SPECTROMETRY.
"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-201 ANDTHR-229, AND MASS SPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, AND MASSSPECTROMETRY.

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