dbPTM

ABL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABL2_HUMAN
UniProt AC	P42684
Protein Name	Tyrosine-protein kinase ABL2
Gene Name	ABL2
Organism	Homo sapiens (Human).
Sequence Length	1182
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1..
Protein Sequence	MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQQVGRVG ------CCCCCCCCC	37.62	-
5 (in isoform 10)	Phosphorylation	-	3.98	24043423
5 (in isoform 2)	Phosphorylation	-	3.98	24043423
5 (in isoform 3)	Phosphorylation	-	3.98	24043423
5 (in isoform 4)	Phosphorylation	-	3.98	24043423
12 (in isoform 10)	Phosphorylation	-	39.46	24043423
12 (in isoform 2)	Phosphorylation	-	39.46	24043423
12 (in isoform 3)	Phosphorylation	-	39.46	24043423
12 (in isoform 4)	Phosphorylation	-	39.46	24043423
13 (in isoform 10)	Phosphorylation	-	43.07	24043423
13 (in isoform 2)	Phosphorylation	-	43.07	24043423
13 (in isoform 3)	Phosphorylation	-	43.07	24043423
13 (in isoform 4)	Phosphorylation	-	43.07	24043423
23	Methylation	QPQPRGIRGSSAARP CCCCCCCCCCCCCCC	41.59	-
25	Phosphorylation	QPRGIRGSSAARPSG CCCCCCCCCCCCCCC	13.62	20068231
26	Phosphorylation	PRGIRGSSAARPSGR CCCCCCCCCCCCCCC	28.86	20068231
31	Phosphorylation	GSSAARPSGRRRDPA CCCCCCCCCCCCCCC	39.10	20068231
57	Phosphorylation	TQHDHFASCVEDGFE CCCCHHHHHHHCCCC	20.11	32142685
59 (in isoform 6)	Phosphorylation	-	7.52	27307780
59 (in isoform 7)	Phosphorylation	-	7.52	27307780
59 (in isoform 8)	Phosphorylation	-	7.52	27307780
60 (in isoform 2)	Phosphorylation	-	57.66	-
68	Phosphorylation	DGFEGDKTGGSSPEA CCCCCCCCCCCCHHH	52.06	25159151
71	Phosphorylation	EGDKTGGSSPEALHR CCCCCCCCCHHHHCC	44.03	25159151
72	Phosphorylation	GDKTGGSSPEALHRP CCCCCCCCHHHHCCC	29.99	25159151
80	Phosphorylation	PEALHRPYGCDVEPQ HHHHCCCCCCCCCHH	30.28	18691976
80 (in isoform 2)	Phosphorylation	-	30.28	-
96	Phosphorylation	LNEAIRWSSKENLLG HHHHHHHHCCCCCCC	22.99	18691976
97	Phosphorylation	NEAIRWSSKENLLGA HHHHHHHCCCCCCCC	36.71	28464451
107	Phosphorylation	NLLGATESDPNLFVA CCCCCCCCCCCEEEE	54.75	28464451
116	Phosphorylation	PNLFVALYDFVASGD CCEEEEEHHHHHCCC	9.52	17192257
121	Phosphorylation	ALYDFVASGDNTLSI EEHHHHHCCCCEEEE	41.18	20071362
125	Phosphorylation	FVASGDNTLSITKGE HHHCCCCEEEEECCC	26.99	20068231
127	Phosphorylation	ASGDNTLSITKGEKL HCCCCEEEEECCCEE	26.61	24719451
139	Phosphorylation	EKLRVLGYNQNGEWS CEEEEEEECCCCCCE	14.93	19275932
159	Phosphorylation	NGQGWVPSNYITPVN CCCCEECCCCCCCCH	32.42	21945579
161	Phosphorylation	QGWVPSNYITPVNSL CCEECCCCCCCCHHH	15.54	21945579
163	Phosphorylation	WVPSNYITPVNSLEK EECCCCCCCCHHHCC	15.72	21945579
164 (in isoform 2)	Phosphorylation	-	17.46	-
167	Phosphorylation	NYITPVNSLEKHSWY CCCCCCHHHCCCCCC	37.83	18691976
167 (in isoform 2)	Phosphorylation	-	37.83	-
172	Phosphorylation	VNSLEKHSWYHGPVS CHHHCCCCCCCCCCC	40.16	21945579
172 (in isoform 2)	Phosphorylation	-	40.16	-
174	Phosphorylation	SLEKHSWYHGPVSRS HHCCCCCCCCCCCHH	10.42	21945579
179	Phosphorylation	SWYHGPVSRSAAEYL CCCCCCCCHHHHHHH	24.53	21945579
185	Phosphorylation	VSRSAAEYLLSSLIN CCHHHHHHHHHHHHC	14.28	-
194	Phosphorylation	LSSLINGSFLVRESE HHHHHCCCEEEEECC	15.77	-
195 (in isoform 2)	Phosphorylation	-	8.51	-
200	Phosphorylation	GSFLVRESESSPGQL CCEEEEECCCCCCEE	32.01	22496350
202	Phosphorylation	FLVRESESSPGQLSI EEEEECCCCCCEEEE	51.62	29255136
203	Phosphorylation	LVRESESSPGQLSIS EEEECCCCCCEEEEE	29.06	29255136
208	Phosphorylation	ESSPGQLSISLRYEG CCCCCEEEEEEEECC	11.40	25159151
210	Phosphorylation	SPGQLSISLRYEGRV CCCEEEEEEEECCEE	11.92	29496963
213	Phosphorylation	QLSISLRYEGRVYHY EEEEEEEECCEEEEE	28.20	23917254
218	Phosphorylation	LRYEGRVYHYRINTT EEECCEEEEEEEEEC	7.56	21447384
224	Phosphorylation	VYHYRINTTADGKVY EEEEEEEECCCCEEE	22.46	28152594
225	Phosphorylation	YHYRINTTADGKVYV EEEEEEECCCCEEEE	20.47	28152594
231	Phosphorylation	TTADGKVYVTAESRF ECCCCEEEEEEECHH	8.79	25159151
233	Phosphorylation	ADGKVYVTAESRFST CCCEEEEEEECHHHH	13.66	28152594
236	Phosphorylation	KVYVTAESRFSTLAE EEEEEEECHHHHHHH	35.84	28152594
236 (in isoform 2)	Phosphorylation	-	35.84	-
239	Phosphorylation	VTAESRFSTLAELVH EEEECHHHHHHHHHH	22.77	18691976
239 (in isoform 2)	Phosphorylation	-	22.77	-
261	Phosphorylation	GLVTTLHYPAPKCNK CCEEEEECCCCCCCC	12.28	15735735
270	Phosphorylation	APKCNKPTVYGVSPI CCCCCCCCEEEECCC	28.15	29978859
272	Phosphorylation	KCNKPTVYGVSPIHD CCCCCCEEEECCCCC	17.81	16464493
275	Phosphorylation	KPTVYGVSPIHDKWE CCCEEEECCCCCCCE	17.49	25159151
277 (in isoform 2)	Phosphorylation	-	5.23	-
286	Phosphorylation	DKWEMERTDITMKHK CCCEECCCEEEEEEE	20.60	24719451
289	Phosphorylation	EMERTDITMKHKLGG EECCCEEEEEEECCC	23.99	-
299	Phosphorylation	HKLGGGQYGEVYVGV EECCCCCCCEEEEEE	20.66	19060867
303	Phosphorylation	GGQYGEVYVGVWKKY CCCCCEEEEEEEECE	6.28	16464493
310	Phosphorylation	YVGVWKKYSLTVAVK EEEEEECEEEEEEEE	12.75	12522270
311	Phosphorylation	VGVWKKYSLTVAVKT EEEEECEEEEEEEEC	26.83	28152594
313	Phosphorylation	VWKKYSLTVAVKTLK EEECEEEEEEEECCC	10.65	20068231
320	Acetylation	TVAVKTLKEDTMEVE EEEEECCCCCCHHHH	59.79	19815467
331	Ubiquitination	MEVEEFLKEAAVMKE HHHHHHHHHHHHHHH	51.10	-
352	Phosphorylation	VQLLGVCTLEPPFYI HHHHCEEECCCCEEE	31.58	22210691
358	Phosphorylation	CTLEPPFYIVTEYMP EECCCCEEEEEECCC	10.56	24043423
361	Phosphorylation	EPPFYIVTEYMPYGN CCCEEEEEECCCCCH	16.31	22210691
363	Phosphorylation	PFYIVTEYMPYGNLL CEEEEEECCCCCHHH	8.27	24043423
366	Phosphorylation	IVTEYMPYGNLLDYL EEEECCCCCHHHHHH	11.34	24043423
372	Phosphorylation	PYGNLLDYLRECNRE CCCHHHHHHHHCCHH	13.97	24043423
388	Phosphorylation	VTAVVLLYMATQISS HHHHHHHHHHHHHHH	4.79	30377224
391	Phosphorylation	VVLLYMATQISSAME HHHHHHHHHHHHHHH	15.20	22210691
394	Phosphorylation	LYMATQISSAMEYLE HHHHHHHHHHHHHHH	11.39	22210691
395	Phosphorylation	YMATQISSAMEYLEK HHHHHHHHHHHHHHH	33.01	22210691
399	Phosphorylation	QISSAMEYLEKKNFI HHHHHHHHHHHCCCC	13.69	22210691
402 (in isoform 2)	Phosphorylation	-	50.88	-
404 (in isoform 2)	Phosphorylation	-	52.77	-
410	Ubiquitination	KNFIHRDLAARNCLV CCCCCHHHHHCCCCC	3.96	22817900
414	Ubiquitination	HRDLAARNCLVGENH CHHHHHCCCCCCCCC	20.81	22817900
425	Ubiquitination	GENHVVKVADFGLSR CCCCEEEEHHHCCCH	4.11	22817900
429	Ubiquitination	VVKVADFGLSRLMTG EEEEHHHCCCHHCCC	24.24	22817900
431	Ubiquitination	KVADFGLSRLMTGDT EEHHHCCCHHCCCCE	24.61	22817900
435	Phosphorylation	FGLSRLMTGDTYTAH HCCCHHCCCCEEECC	36.18	21945579
435	Ubiquitination	FGLSRLMTGDTYTAH HCCCHHCCCCEEECC	36.18	22817900
438	Phosphorylation	SRLMTGDTYTAHAGA CHHCCCCEEECCCCC	24.90	21945579
439	Phosphorylation	RLMTGDTYTAHAGAK HHCCCCEEECCCCCC	13.48	22322096
440	Phosphorylation	LMTGDTYTAHAGAKF HCCCCEEECCCCCCC	17.66	21945579
446	Ubiquitination	YTAHAGAKFPIKWTA EECCCCCCCCCEECC	51.24	22817900
450	Ubiquitination	AGAKFPIKWTAPESL CCCCCCCEECCCCHH	38.44	22817900
452	Phosphorylation	AKFPIKWTAPESLAY CCCCCEECCCCHHHC	27.60	-
459	Phosphorylation	TAPESLAYNTFSIKS CCCCHHHCCCCCCCC	21.74	-
492	Phosphorylation	PYPGIDLSQVYDLLE CCCCCCHHHHHHHHH	17.53	-
515	Phosphorylation	EGCPPKVYELMRACW CCCCHHHHHHHHHHH	14.96	12522270
542	Ubiquitination	THQAFETMFHDSSIS HHHHHHHHHCCCCCC	1.90	29967540
557	Ubiquitination	EEVAEELGRAASSSS HHHHHHHHHHHHCCC	22.06	29967540
561	Phosphorylation	EELGRAASSSSVVPY HHHHHHHHCCCCCCC	29.75	28442448
562	Phosphorylation	ELGRAASSSSVVPYL HHHHHHHCCCCCCCC	23.16	21945579
563	Phosphorylation	LGRAASSSSVVPYLP HHHHHHCCCCCCCCC	25.34	21945579
563	Ubiquitination	LGRAASSSSVVPYLP HHHHHHCCCCCCCCC	25.34	29967540
563 (in isoform 2)	Phosphorylation	-	25.34	-
564	Phosphorylation	GRAASSSSVVPYLPR HHHHHCCCCCCCCCC	29.14	28442448
566 (in isoform 2)	Phosphorylation	-	2.52	-
568	Phosphorylation	SSSSVVPYLPRLPIL HCCCCCCCCCCCCCC	20.09	21945579
577	Phosphorylation	PRLPILPSKTRTLKK CCCCCCCCCCHHHHH	43.12	21945579
578	Acetylation	RLPILPSKTRTLKKQ CCCCCCCCCHHHHHH	39.83	25953088
578	Ubiquitination	RLPILPSKTRTLKKQ CCCCCCCCCHHHHHH	39.83	29967540
581	Phosphorylation	ILPSKTRTLKKQVEN CCCCCCHHHHHHHHC	48.43	18691976
581 (in isoform 2)	Phosphorylation	-	48.43	-
582 (in isoform 2)	Phosphorylation	-	6.17	-
584 (in isoform 2)	Phosphorylation	-	63.79	-
595	Phosphorylation	NKENIEGAQDATENS CCCCCCCCCCCCCCC	7.41	32142685
595 (in isoform 2)	Phosphorylation	-	7.41	-
597 (in isoform 2)	Phosphorylation	-	55.73	-
598 (in isoform 2)	Phosphorylation	-	12.53	-
599	Phosphorylation	IEGAQDATENSASSL CCCCCCCCCCCHHHC	43.95	18691976
602	Phosphorylation	AQDATENSASSLAPG CCCCCCCCHHHCCCC	24.24	25159151
604	Phosphorylation	DATENSASSLAPGFI CCCCCCHHHCCCCHH	26.21	25850435
605	Phosphorylation	ATENSASSLAPGFIR CCCCCHHHCCCCHHH	28.41	25850435
610	Phosphorylation	ASSLAPGFIRGAQAS HHHCCCCHHHCHHCC	3.15	32142685
616	Phosphorylation	GFIRGAQASSGSPAL CHHHCHHCCCCCCCC	12.72	32142685
617	Phosphorylation	FIRGAQASSGSPALP HHHCHHCCCCCCCCC	24.13	30266825
618	Phosphorylation	IRGAQASSGSPALPR HHCHHCCCCCCCCCH	46.43	30266825
619 (in isoform 2)	Phosphorylation	-	34.84	-
620	Phosphorylation	GAQASSGSPALPRKQ CHHCCCCCCCCCHHH	14.67	19664994
631	Phosphorylation	PRKQRDKSPSSLLED CHHHCCCCHHHHHHH	34.01	29255136
633	Phosphorylation	KQRDKSPSSLLEDAK HHCCCCHHHHHHHHH	40.48	29255136
634	Phosphorylation	QRDKSPSSLLEDAKE HCCCCHHHHHHHHHH	40.12	30266825
634 (in isoform 4)	Phosphorylation	-	40.12	24719451
635 (in isoform 2)	Phosphorylation	-	7.72	-
642	Phosphorylation	LLEDAKETCFTRDRK HHHHHHHHHCCCCCC	16.53	24732914
645	Phosphorylation	DAKETCFTRDRKGGF HHHHHHCCCCCCCCC	33.53	24732914
647 (in isoform 4)	Phosphorylation	-	54.29	28796482
649 (in isoform 7)	Phosphorylation	-	68.61	24719451
654	Phosphorylation	DRKGGFFSSFMKKRN CCCCCCHHHHHHHCC	22.02	25159151
655	Phosphorylation	RKGGFFSSFMKKRNA CCCCCHHHHHHHCCC	24.97	28355574
655 (in isoform 10)	Phosphorylation	-	24.97	24719451
659	Acetylation	FFSSFMKKRNAPTPP CHHHHHHHCCCCCCC	38.81	7678533
662 (in isoform 7)	Phosphorylation	-	17.24	28796482
664	Phosphorylation	MKKRNAPTPPKRSSS HHHCCCCCCCCCCHH	50.22	21815630
667	"N6,N6-dimethyllysine"	RNAPTPPKRSSSFRE CCCCCCCCCCHHHHH	67.14	-
667	Methylation	RNAPTPPKRSSSFRE CCCCCCCCCCHHHHH	67.14	-
668 (in isoform 10)	Phosphorylation	-	47.77	28796482
669	Phosphorylation	APTPPKRSSSFREME CCCCCCCCHHHHHHC	36.14	23403867
670	Phosphorylation	PTPPKRSSSFREMEN CCCCCCCHHHHHHCC	37.21	23403867
670	Ubiquitination	PTPPKRSSSFREMEN CCCCCCCHHHHHHCC	37.21	29967540
670 (in isoform 5)	Phosphorylation	-	37.21	24719451
671	Phosphorylation	TPPKRSSSFREMENQ CCCCCCHHHHHHCCC	29.57	25159151
681	Phosphorylation	EMENQPHKKYELTGN HHCCCCCCEEECCCC	64.83	33259812
682 (in isoform 2)	Phosphorylation	-	40.71	-
683	Phosphorylation	ENQPHKKYELTGNFS CCCCCCEEECCCCCC	22.45	22817900
683 (in isoform 5)	Phosphorylation	-	22.45	28796482
685	Ubiquitination	QPHKKYELTGNFSSV CCCCEEECCCCCCCC	7.25	29967540
691	Ubiquitination	ELTGNFSSVASLQHA ECCCCCCCCEEEEEC	19.98	29967540
696	Phosphorylation	FSSVASLQHADGFSF CCCCEEEEECCCCCC	27.51	33259812
702	Phosphorylation	LQHADGFSFTPAQQE EEECCCCCCCHHHHH	33.47	33259812
706	Ubiquitination	DGFSFTPAQQEANLV CCCCCCHHHHHCCCC	22.19	29967540
717	Phosphorylation	ANLVPPKCYGGSFAQ CCCCCCCCCCCCHHH	4.75	33259812
718	Phosphorylation	NLVPPKCYGGSFAQR CCCCCCCCCCCHHHC	30.55	27273156
738	Phosphorylation	DGGGGGGSGTAGGGW CCCCCCCCCCCCCCC	35.92	30576142
745 (in isoform 2)	Phosphorylation	-	9.17	-
747 (in isoform 2)	Phosphorylation	-	18.24	-
748 (in isoform 2)	Phosphorylation	-	2.58	-
749	Phosphorylation	GGGWSGITGFFTPRL CCCCCCCCCCCCHHH	31.31	30576142
752 (in isoform 2)	Phosphorylation	-	11.00	-
753	Phosphorylation	SGITGFFTPRLIKKT CCCCCCCCHHHHHHH	12.77	18691976
753 (in isoform 2)	Phosphorylation	-	12.77	-
762	Phosphorylation	RLIKKTLGLRAGKPT HHHHHHHCCCCCCCC	20.53	32645325
768	Phosphorylation	LGLRAGKPTASDDTS HCCCCCCCCCCCCCC	32.07	32645325
771	Phosphorylation	RAGKPTASDDTSKPF CCCCCCCCCCCCCCC	38.20	28555341
776	Acetylation	TASDDTSKPFPRSNS CCCCCCCCCCCCCCC	53.41	-
779 (in isoform 2)	Phosphorylation	-	47.52	-
781	Phosphorylation	TSKPFPRSNSTSSMS CCCCCCCCCCCCCCC	35.06	17525332
781 (in isoform 2)	Phosphorylation	-	35.06	-
782 (in isoform 2)	Phosphorylation	-	51.06	-
783	Phosphorylation	KPFPRSNSTSSMSSG CCCCCCCCCCCCCCC	30.80	23401153
784	Phosphorylation	PFPRSNSTSSMSSGL CCCCCCCCCCCCCCC	29.13	29255136
784 (in isoform 2)	Phosphorylation	-	29.13	-
785	Phosphorylation	FPRSNSTSSMSSGLP CCCCCCCCCCCCCCC	24.70	29255136
786	Phosphorylation	PRSNSTSSMSSGLPE CCCCCCCCCCCCCCH	23.83	29255136
788	Phosphorylation	SNSTSSMSSGLPEQD CCCCCCCCCCCCHHH	24.17	28450419
788	Ubiquitination	SNSTSSMSSGLPEQD CCCCCCCCCCCCHHH	24.17	29967540
789	Phosphorylation	NSTSSMSSGLPEQDR CCCCCCCCCCCHHHH	35.39	28450419
794	Ubiquitination	MSSGLPEQDRMAMTL CCCCCCHHHHHHHHC	41.49	29967540
797	Phosphorylation	GLPEQDRMAMTLPRN CCCHHHHHHHHCCCC	3.93	32142685
799	Phosphorylation	PEQDRMAMTLPRNCQ CHHHHHHHHCCCCHH	2.64	33259812
800	Phosphorylation	EQDRMAMTLPRNCQR HHHHHHHHCCCCHHC	24.87	28555341
805	Phosphorylation	AMTLPRNCQRSKLQL HHHCCCCHHCCHHEE	3.62	33259812
808	Phosphorylation	LPRNCQRSKLQLERT CCCCHHCCHHEEEEE	16.31	30622161
809	Ubiquitination	PRNCQRSKLQLERTV CCCHHCCHHEEEEEE	42.30	29967540
812	Phosphorylation	CQRSKLQLERTVSTS HHCCHHEEEEEECCC	7.53	32142685
815	Phosphorylation	SKLQLERTVSTSSQP CHHEEEEEECCCCCC	14.94	21955146
817	Phosphorylation	LQLERTVSTSSQPEE HEEEEEECCCCCCHH	23.20	25159151
818	Phosphorylation	QLERTVSTSSQPEEN EEEEEECCCCCCHHH	28.23	25159151
818	Ubiquitination	QLERTVSTSSQPEEN EEEEEECCCCCCHHH	28.23	29967540
819	Phosphorylation	LERTVSTSSQPEENV EEEEECCCCCCHHHH	21.33	25159151
820	Phosphorylation	ERTVSTSSQPEENVD EEEECCCCCCHHHHH	50.25	25159151
828 (in isoform 2)	Phosphorylation	-	30.89	-
833	Phosphorylation	VDRANDMLPKKSEES HHHHHHCCCCCCHHC	6.66	32142685
833	Ubiquitination	VDRANDMLPKKSEES HHHHHHCCCCCCHHC	6.66	29967540
839	Ubiquitination	MLPKKSEESAAPSRE CCCCCCHHCCCCCCC	53.41	29967540
854	Ubiquitination	RPKAKLLPRGATALP CCCCCCCCCCCCCCC	42.99	29967540
858	Phosphorylation	KLLPRGATALPLRTP CCCCCCCCCCCCCCC	31.39	29514088
864	Phosphorylation	ATALPLRTPSGDLAI CCCCCCCCCCCCEEE	29.50	17192257
866	Phosphorylation	ALPLRTPSGDLAITE CCCCCCCCCCEEEEE	44.31	21815630
872	Phosphorylation	PSGDLAITEKDPPGV CCCCEEEEECCCCCC	31.23	20068231
879 (in isoform 2)	Phosphorylation	-	7.41	-
900 (in isoform 2)	Phosphorylation	-	9.80	-
902 (in isoform 2)	Phosphorylation	-	17.65	-
915	Phosphorylation	GEQPGWPSPAKAAPV CCCCCCCCCCCCCCC	30.86	25159151
921	Phosphorylation	PSPAKAAPVLPTTHN CCCCCCCCCCCCCCC	32.79	32142685
925	Phosphorylation	KAAPVLPTTHNHKVP CCCCCCCCCCCCCCC	36.20	23312004
926	Phosphorylation	AAPVLPTTHNHKVPV CCCCCCCCCCCCCCE	20.81	23312004
930	Phosphorylation	LPTTHNHKVPVLISP CCCCCCCCCCEEECC	54.26	32142685
932 (in isoform 2)	Phosphorylation	-	21.72	-
936	Phosphorylation	HKVPVLISPTLKHTP CCCCEEECCCCCCCC	13.99	19664994
936	Ubiquitination	HKVPVLISPTLKHTP CCCCEEECCCCCCCC	13.99	29967540
938	Phosphorylation	VPVLISPTLKHTPAD CCEEECCCCCCCCCC	41.47	30266825
942	Ubiquitination	ISPTLKHTPADVQLI ECCCCCCCCCCEEEE	20.70	29967540
951	Phosphorylation	ADVQLIGTDSQGNKF CCEEEEEECCCCCEE	26.03	32142685
953	Phosphorylation	VQLIGTDSQGNKFKL EEEEEECCCCCEEEE	39.56	25627689
957	Methylation	GTDSQGNKFKLLSEH EECCCCCEEEEEEEC	51.18	-
957	Ubiquitination	GTDSQGNKFKLLSEH EECCCCCEEEEEEEC	51.18	29967540
959	Methylation	DSQGNKFKLLSEHQV CCCCCEEEEEEECCC	50.56	-
962	Phosphorylation	GNKFKLLSEHQVTSS CCEEEEEEECCCCCC	43.39	27174698
967	Phosphorylation	LLSEHQVTSSGDKDR EEEECCCCCCCCCCC	15.59	27174698
968	Phosphorylation	LSEHQVTSSGDKDRP EEECCCCCCCCCCCC	33.20	18691976
969	Phosphorylation	SEHQVTSSGDKDRPR EECCCCCCCCCCCCC	41.46	25159151
981	Acetylation	RPRRVKPKCAPPPPP CCCCCCCCCCCCCCC	36.99	30586989
997	Phosphorylation	MRLLQHPSICSDPTE HHHHCCCCCCCCCCC	33.82	25159151
1000	Phosphorylation	LQHPSICSDPTEEPT HCCCCCCCCCCCCCC	44.98	25159151
1003	Phosphorylation	PSICSDPTEEPTALT CCCCCCCCCCCCCCC	58.95	23312004
1014 (in isoform 2)	Phosphorylation	-	32.74	-
1018 (in isoform 2)	Phosphorylation	-	31.52	-
1023	Acetylation	SETQEGGKKAALGAV CCCCCCCCEEEEECC	50.53	26051181
1033	Phosphorylation	ALGAVPISGKAGRPV EEECCCCCCCCCCCC	28.33	32142685
1039	Phosphorylation	ISGKAGRPVMPPPQV CCCCCCCCCCCCCCC	26.33	32142685
1050	Phosphorylation	PPQVPLPTSSISPAK CCCCCCCCCCCCHHH	42.67	25159151
1051	Phosphorylation	PQVPLPTSSISPAKM CCCCCCCCCCCHHHC	24.59	30576142
1052	Phosphorylation	QVPLPTSSISPAKMA CCCCCCCCCCHHHCC	29.57	30576142
1054	Phosphorylation	PLPTSSISPAKMANG CCCCCCCCHHHCCCC	22.28	25159151
1057	Methylation	TSSISPAKMANGTAG CCCCCHHHCCCCCCC	41.76	-
1066	Methylation	ANGTAGTKVALRKTK CCCCCCCHHHHHHHH	25.29	-
1072	Phosphorylation	TKVALRKTKQAAEKI CHHHHHHHHHHHHHC	23.19	29396449
1107	Phosphorylation	LTEPVPNSQLVDTGH HCCCCCCHHHCCCHH	20.87	-
1112	Phosphorylation	PNSQLVDTGHQLLDY CCHHHCCCHHHHHHH	29.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
116	Y	Phosphorylation	Kinase	LYN	P07948	GPS
116	Y	Phosphorylation	Kinase	HCK	P08631	GPS
116	Y	Phosphorylation	Kinase	FYN	P06241	GPS
139	Y	Phosphorylation	Kinase	PDGFRB	P09619	PSP
161	Y	Phosphorylation	Kinase	PDGFRB	P09619	PSP
161	Y	Phosphorylation	Kinase	LYN	P07948	GPS
161	Y	Phosphorylation	Kinase	HCK	P08631	GPS
161	Y	Phosphorylation	Kinase	FYN	P06241	GPS
174	Y	Phosphorylation	Kinase	HCK	P08631	GPS
174	Y	Phosphorylation	Kinase	LYN	P07948	GPS
174	Y	Phosphorylation	Kinase	FYN	P06241	GPS
185	Y	Phosphorylation	Kinase	FYN	P06241	GPS
185	Y	Phosphorylation	Kinase	HCK	P08631	GPS
185	Y	Phosphorylation	Kinase	LYN	P07948	GPS
218	Y	Phosphorylation	Kinase	FYN	P06241	GPS
218	Y	Phosphorylation	Kinase	HCK	P08631	GPS
218	Y	Phosphorylation	Kinase	LYN	P07948	GPS
231	Y	Phosphorylation	Kinase	FYN	P06241	GPS
231	Y	Phosphorylation	Kinase	HCK	P08631	GPS
231	Y	Phosphorylation	Kinase	LYN	P07948	GPS
261	Y	Phosphorylation	Kinase	LYN	P07948	GPS
261	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
261	Y	Phosphorylation	Kinase	HCK	P08631	GPS
261	Y	Phosphorylation	Kinase	FYN	P06241	GPS
261	Y	Phosphorylation	Kinase	ABL	P00519	PSP
272	Y	Phosphorylation	Kinase	PDGFRB	P09619	PSP
439	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
439	Y	Phosphorylation	Kinase	SRC-TYPE TYR-KINASES	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ABL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABL1_HUMAN	ABL1	physical	12569093
CATA_HUMAN	CAT	physical	12777400
SRBS2_HUMAN	SORBS2	physical	9211900
PSA7_HUMAN	PSMA7	physical	16678104
ERBB4_HUMAN	ERBB4	physical	16273093
FBX38_HUMAN	FBXO38	physical	21988832
HCK_HUMAN	HCK	physical	21988832
TPD53_HUMAN	TPD52L1	physical	21988832
NMES1_HUMAN	C15orf48	physical	21988832
MS18B_HUMAN	OIP5	physical	21988832
GPX1_HUMAN	GPX1	physical	12893824
CIP4_HUMAN	TRIP10	physical	18330356
ABL2_HUMAN	ABL2	physical	15735735
CRK_HUMAN	CRK	physical	8194526
GRB2_HUMAN	GRB2	physical	8194526
RIN1_HUMAN	RIN1	physical	15886098
ABL2_HUMAN	ABL2	physical	15886098
CRK_CHICK	CRK	physical	15886098
CRK_HUMAN	CRK	physical	15886098
RASH_HUMAN	HRAS	physical	15886098
MDM2_HUMAN	MDM2	physical	25624478
P55G_HUMAN	PIK3R3	physical	25814554

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ABL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817; SER-820 ANDSER-936, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-620; SER-631;TYR-683; TYR-718; SER-781; THR-784; THR-815; SER-817; SER-819; SER-820AND SER-936, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-620; SER-631; SER-783;SER-817; THR-818; SER-819; SER-820; SER-936 AND THR-938, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-620; SER-631; SER-633;SER-655; SER-817; SER-820; SER-915 AND SER-936, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-116; SER-203; TYR-231;SER-275; SER-602; SER-620; SER-631; SER-671; TYR-718; SER-820;THR-864; SER-915 AND SER-936, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, AND MASSSPECTROMETRY.	18187866 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 AND SER-820, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; SER-783; SER-817AND SER-936, AND MASS SPECTROMETRY.	17192257 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-631, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry."; Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.; Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-310; TYR-439; THR-440AND TYR-515, AND MASS SPECTROMETRY.	12522270 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-439, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-439, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Ubiquitination and degradation of the Arg tyrosine kinase isregulated by oxidative stress."; Cao C., Li Y., Leng Y., Li P., Ma Q., Kufe D.; Oncogene 24:2433-2440(2005). Cited for: FUNCTION, PHOSPHORYLATION AT TYR-261, AND UBIQUITINATION.	15735735 [Abstract]
"Two distinct phosphorylation pathways have additive effects on Ablfamily kinase activation."; Tanis K.Q., Veach D., Duewel H.S., Bornmann W.G., Koleske A.J.; Mol. Cell. Biol. 23:3884-3896(2003). Cited for: AUTOPHOSPHORYLATION AT TYR-272; TYR-439; TYR-568 AND TYR-683, ANDENZYME REGULATION.	12748290 [Abstract]