GPX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPX1_HUMAN
• UniProt AC: P07203
• Protein Name: Glutathione peroxidase 1
• Gene Name: GPX1
• Organism: Homo sapiens (Human).
• Sequence Length: 203
• Subcellular Localization: Cytoplasm.
• Protein Description: Protects the hemoglobin in erythrocytes from oxidative breakdown..
• Protein Sequence: MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	LAGGEPVSLGSLRGK CCCCCCCCCCHHCCE	37.41	29255136
34	Phosphorylation	GEPVSLGSLRGKVLL CCCCCCCHHCCEEEE	21.86	29255136
56	Phosphorylation	UGTTVRDYTQMNELQ CCCCHHHHHHHHHHH	6.57	28796482
59	Sulfoxidation	TVRDYTQMNELQRRL CHHHHHHHHHHHHHH	3.03	30846556
88	Succinylation	FGHQENAKNEEILNS CCCCCHHCCHHHHHH	76.19	-
88	Acetylation	FGHQENAKNEEILNS CCCCCHHCCHHHHHH	76.19	26051181
88	Succinylation	FGHQENAKNEEILNS CCCCCHHCCHHHHHH	76.19	-
96	Phosphorylation	NEEILNSLKYVRPGG CHHHHHHCCCCCCCC	4.52	12893824
98	Phosphorylation	EILNSLKYVRPGGGF HHHHHCCCCCCCCCC	13.64	12893824
110	Sulfoxidation	GGFEPNFMLFEKCEV CCCCCCEEEEEEEEE	5.49	30846556
114	Succinylation	PNFMLFEKCEVNGAG CCEEEEEEEEECCCC	28.50	-
114	Succinylation	PNFMLFEKCEVNGAG CCEEEEEEEEECCCC	28.50	-
114	Acetylation	PNFMLFEKCEVNGAG CCEEEEEEEEECCCC	28.50	-
144	Sulfoxidation	SDDATALMTDPKLIT CCCCCHHHCCCEEEE	3.56	30846556
145	Phosphorylation	DDATALMTDPKLITW CCCCHHHCCCEEEEE	50.42	26437602
148	Succinylation	TALMTDPKLITWSPV CHHHCCCEEEEECCC	56.16	-
148	Succinylation	TALMTDPKLITWSPV CHHHCCCEEEEECCC	56.16	-
148	Acetylation	TALMTDPKLITWSPV CHHHCCCEEEEECCC	56.16	25038526
151	Phosphorylation	MTDPKLITWSPVCRN HCCCEEEEECCCCCC	30.26	23403867
153	Phosphorylation	DPKLITWSPVCRNDV CCEEEEECCCCCCCC	9.98	23927012
166	Ubiquitination	DVAWNFEKFLVGPDG CCHHCHHHHCCCCCC	39.60	-
180	Phosphorylation	GVPLRRYSRRFQTID CCCCCHHCCCEEECC	18.37	-
197	Phosphorylation	PDIEALLSQGPSCA- CCHHHHHHCCCCCC-	33.66	-
201	Phosphorylation	ALLSQGPSCA----- HHHHCCCCCC-----	29.51	12496980
202	Glutathionylation	LLSQGPSCA------ HHHCCCCCC------	6.15	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
96	Y	Phosphorylation	Kinase	ABL1	P00519	PhosphoELM
96	Y	Phosphorylation	Kinase	ABL2	P42684	PhosphoELM
98	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
98	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
98	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABL1_HUMAN	ABL1	physical	12893824
SBP1_HUMAN	SELENBP1	physical	20530237
ABL2_HUMAN	ABL2	physical	12893824
EXOS2_HUMAN	EXOSC2	physical	22863883
SYK_HUMAN	KARS	physical	22863883
THIO_HUMAN	TXN	physical	22863883
FAM9B_HUMAN	FAM9B	physical	24722188

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione