CRK_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRK_CHICK
• UniProt AC: Q04929
• Protein Name: Adapter molecule crk
• Gene Name: CRK
• Organism: Gallus gallus (Chicken).
• Sequence Length: 305
• Subcellular Localization: Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion..
• Protein Description: May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity)..
• Protein Sequence: MAGQFDSEDRGSWYWGRLSRGDAVSLLQGQRHGTFLVRDSGSIPGDFVLSVSESSRVSHYIVNSLGPAGGRRAGGEGPGAPGLNPTRFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSRSRQNSGVILRQEEVEYVRALFDFNGNDDEDLPFKKGDILKIRDKPEEQWWNAEDMDGKRGMIPVPYVEKCRPSSASVSTLTGGNQDSSHPQPLGGPEPGPYAQPSINTPLPNLQNGPFYARVIQKRVPNAYDKTALALEVGELVKVTKINMSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	Phosphorylation	GGPEPGPYAQPSINT CCCCCCCCCCCCCCC	24.63	-
240	Phosphorylation	NLQNGPFYARVIQKR CCCCCCEEHHHHHHH	9.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
222	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
222	Y	Phosphorylation	Kinase	ABL2	P42684	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRK_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRK_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.