dbPTM

ARHG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARHG5_HUMAN
UniProt AC	Q12774
Protein Name	Rho guanine nucleotide exchange factor 5
Gene Name	ARHGEF5
Organism	Homo sapiens (Human).
Sequence Length	1597
Subcellular Localization	Cytoplasm . Nucleus . Cell projection, podosome .
Protein Description	Guanine nucleotide exchange factor which activates Rho GTPases. [PubMed: 15601624 Strongly activates RHOA]
Protein Sequence	MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	EEAQRGASPPISAIE HHHHCCCCCCCHHHH	33.75	29255136
15	Phosphorylation	RGASPPISAIEEFSI CCCCCCCHHHHEEEC	29.03	29255136
19	Phosphorylation	PPISAIEEFSIIPEA CCCHHHHEEECCCCC	38.28	15951569
21	Phosphorylation	ISAIEEFSIIPEAPM CHHHHEEECCCCCCC	23.92	23663014
22	Phosphorylation	SAIEEFSIIPEAPMR HHHHEEECCCCCCCC	8.06	15951569
29 (in isoform 2)	Ubiquitination	-	31.90	21906983
30	Phosphorylation	IPEAPMRSSQVSALG CCCCCCCCCCCHHHC	20.90	27251275
31	Phosphorylation	PEAPMRSSQVSALGL CCCCCCCCCCHHHCC	25.00	27251275
34	Phosphorylation	PMRSSQVSALGLEAQ CCCCCCCHHHCCCCC	15.33	27251275
57	Phosphorylation	WREEHRLSATQQSEL HHHHHCCCHHHHHHH	29.27	29255136
59	Phosphorylation	EEHRLSATQQSELRD HHHCCCHHHHHHHHH	24.62	29255136
62	Phosphorylation	RLSATQQSELRDVCD CCCHHHHHHHHHHHH	28.87	20068231
70	Phosphorylation	ELRDVCDYAIETMPS HHHHHHHHHHHHCCC	12.35	25106551
74	Phosphorylation	VCDYAIETMPSFPKE HHHHHHHHCCCCCCC	28.41	27251275
77	Phosphorylation	YAIETMPSFPKEGSA HHHHHCCCCCCCCCC	43.27	28348404
92	Phosphorylation	DVEPNQESLVAEACD CCCCCHHHHHHHHCC	20.55	26657352
100	Phosphorylation	LVAEACDTPEHWEAV HHHHHCCCHHHHHHC	30.38	29496963
145	Phosphorylation	PFSSDLGSEEEEVEF CCCCCCCCCHHHCCC	49.48	22468782
182	Phosphorylation	DNSGQTRYYSPCEEH CCCCCEEEECCCCCC	16.22	29255136
183	Phosphorylation	NSGQTRYYSPCEEHP CCCCEEEECCCCCCC	11.66	23663014
184	Phosphorylation	SGQTRYYSPCEEHPA CCCEEEECCCCCCCC	17.72	23401153
193	Phosphorylation	CEEHPAETNQNEGSE CCCCCCCCCCCCCCC	44.18	29255136
199	Phosphorylation	ETNQNEGSESGTIRQ CCCCCCCCCCCCCCC	23.55	23927012
251 (in isoform 2)	Ubiquitination	-	4.40	-
265 (in isoform 2)	Ubiquitination	-	6.73	21906983
294	Phosphorylation	QGERMGLTGEPEGLN CCCCCCCCCCCCCCC	33.50	26074081
340	Phosphorylation	PEENRADSQDEKSQT CHHHCCCCCCHHHHH	38.25	26657352
381	Phosphorylation	QEAKEPESWDGGRLG CCCCCCCCCCCCCCC	40.98	24719451
395	Phosphorylation	GAVGRARSREEENEH CHHHCCCCHHHHHCC	42.96	28348404
406	Phosphorylation	ENEHHGPSMPALIAP HHCCCCCCCCCEECC	41.83	28348404
445	Phosphorylation	ESRAEELSPAALSPS HHHHHHCCCCHHCCC	18.77	29255136
450	Phosphorylation	ELSPAALSPSLEPIR HCCCCHHCCCCCCCC	14.02	29255136
452	Phosphorylation	SPAALSPSLEPIRCS CCCHHCCCCCCCCCC	41.82	29255136
464	Phosphorylation	RCSHQPISLLGSFLT CCCCCCHHHHHHHHC	24.99	28102081
468	Phosphorylation	QPISLLGSFLTEESP CCHHHHHHHHCCCCC	19.63	25159151
471	Phosphorylation	SLLGSFLTEESPDKE HHHHHHHCCCCCCCC	35.38	22199227
474	Phosphorylation	GSFLTEESPDKEIDQ HHHHCCCCCCCCCCC	31.97	30576142
494	Phosphorylation	ESRLRKGTVSSQGTE HHHHHCCCCCCCCCE	21.90	-
506	Phosphorylation	GTEVVFASASVTPPR CCEEEEEEEECCCCC	15.04	28348404
508	Phosphorylation	EVVFASASVTPPRTP EEEEEEEECCCCCCC	24.83	28348404
510	Phosphorylation	VFASASVTPPRTPDS EEEEEECCCCCCCCC	25.69	28348404
514	Phosphorylation	ASVTPPRTPDSAPPS EECCCCCCCCCCCCC	36.90	27251275
517	Phosphorylation	TPPRTPDSAPPSPAE CCCCCCCCCCCCCCC	43.83	26657352
521	Phosphorylation	TPDSAPPSPAEAYPI CCCCCCCCCCCCCCC	35.37	26657352
526	Phosphorylation	PPSPAEAYPITPASV CCCCCCCCCCCCCCC	6.15	27251275
529	Phosphorylation	PAEAYPITPASVSAR CCCCCCCCCCCCCCC	14.32	27251275
532	Phosphorylation	AYPITPASVSARPPV CCCCCCCCCCCCCCC	20.15	27251275
534	Phosphorylation	PITPASVSARPPVAF CCCCCCCCCCCCCCC	18.96	27251275
566	Phosphorylation	PLSMDDPSPCGTSEM CCCCCCCCCCCCCCC	39.56	28985074
570	Phosphorylation	DDPSPCGTSEMCPAA CCCCCCCCCCCCCHH	28.38	28985074
579	Phosphorylation	EMCPAALYGFPSTGT CCCCHHHCCCCCCCC	16.40	-
583	Phosphorylation	AALYGFPSTGTSPPR HHHCCCCCCCCCCCC	36.89	28348404
584	Phosphorylation	ALYGFPSTGTSPPRP HHCCCCCCCCCCCCC	44.72	28348404
586	Phosphorylation	YGFPSTGTSPPRPPA CCCCCCCCCCCCCCC	37.84	28348404
587	Phosphorylation	GFPSTGTSPPRPPAN CCCCCCCCCCCCCCC	33.96	24505115
604	Phosphorylation	GTVQHLRSDSFPGSH CCCCHHHCCCCCCCC	43.92	23927012
606	Phosphorylation	VQHLRSDSFPGSHRT CCHHHCCCCCCCCCC	34.29	25849741
610	Phosphorylation	RSDSFPGSHRTEQTP HCCCCCCCCCCCCCC	15.27	23927012
625	Phosphorylation	DLVGMLLSYSHSELP CHHHHHHHCCCCCCC	22.19	28348404
627	Phosphorylation	VGMLLSYSHSELPQR HHHHHHCCCCCCCCC	19.70	28348404
641	Phosphorylation	RPPKPAIYSSVTPRR CCCCCCEEECCCCCC	9.30	25159151
642	Phosphorylation	PPKPAIYSSVTPRRD CCCCCEEECCCCCCC	16.54	25159151
643	Phosphorylation	PKPAIYSSVTPRRDR CCCCEEECCCCCCCC	17.03	25159151
645	Phosphorylation	PAIYSSVTPRRDRRS CCEEECCCCCCCCCC	17.02	25159151
652	Phosphorylation	TPRRDRRSGRDYSTV CCCCCCCCCCCCCCC	38.79	25159151
656	Phosphorylation	DRRSGRDYSTVSASP CCCCCCCCCCCCCCH	12.60	21082442
657	Phosphorylation	RRSGRDYSTVSASPT CCCCCCCCCCCCCHH	26.99	21082442
658	Phosphorylation	RSGRDYSTVSASPTA CCCCCCCCCCCCHHH	16.55	21082442
660	Phosphorylation	GRDYSTVSASPTALS CCCCCCCCCCHHHHH	24.10	28152594
662	Phosphorylation	DYSTVSASPTALSTL CCCCCCCCHHHHHHH	18.44	28355574
664	Phosphorylation	STVSASPTALSTLKQ CCCCCCHHHHHHHCC	37.42	28450419
667	Phosphorylation	SASPTALSTLKQDSQ CCCHHHHHHHCCCCH	29.27	28450419
668	Phosphorylation	ASPTALSTLKQDSQE CCHHHHHHHCCCCHH	38.53	28450419
673	Phosphorylation	LSTLKQDSQESISNL HHHHCCCCHHHHHCC	33.10	20068231
676	Phosphorylation	LKQDSQESISNLERP HCCCCHHHHHCCCCC	24.55	20068231
678	Phosphorylation	QDSQESISNLERPSS CCCHHHHHCCCCCCC	44.64	20068231
684	Phosphorylation	ISNLERPSSPPSIQP HHCCCCCCCCCCCCC	62.79	28348404
685	Phosphorylation	SNLERPSSPPSIQPW HCCCCCCCCCCCCCC	43.44	20068231
688	Phosphorylation	ERPSSPPSIQPWVSP CCCCCCCCCCCCCCC	36.92	22468782
694	Phosphorylation	PSIQPWVSPHNPAFA CCCCCCCCCCCCCCC	19.30	20068231
702	Phosphorylation	PHNPAFATESPAYGS CCCCCCCCCCCCCCC	30.46	28348404
704	Phosphorylation	NPAFATESPAYGSSP CCCCCCCCCCCCCCC	15.52	28348404
707	Phosphorylation	FATESPAYGSSPSFV CCCCCCCCCCCCCCC	22.41	20068231
709	Phosphorylation	TESPAYGSSPSFVSM CCCCCCCCCCCCCCH	26.80	28348404
710	Phosphorylation	ESPAYGSSPSFVSME CCCCCCCCCCCCCHH	21.87	28348404
712	Phosphorylation	PAYGSSPSFVSMEDV CCCCCCCCCCCHHHC	39.98	20068231
715	Phosphorylation	GSSPSFVSMEDVRIH CCCCCCCCHHHCEEC	17.91	20068231
735	Phosphorylation	PPPQRRDTHPSVVET CCCCCCCCCCCEEEC	33.60	27422710
738	Phosphorylation	QRRDTHPSVVETDGH CCCCCCCCEEECCCC	31.06	29978859
757	Phosphorylation	VPTLKQHSHPPPLAL ECCCHHCCCCCCCCC	34.88	27251275
780	Phosphorylation	KGPLPQASDPAVARQ CCCCCCCCCHHHHHC	38.59	25332170
793	Phosphorylation	RQHRPLPSTPDSSHH HCCCCCCCCCCCCCC	61.32	23312004
794	Phosphorylation	QHRPLPSTPDSSHHA CCCCCCCCCCCCCCC	29.22	28348404
797	Phosphorylation	PLPSTPDSSHHAQAT CCCCCCCCCCCCCCC	32.54	23312004
798	Phosphorylation	LPSTPDSSHHAQATP CCCCCCCCCCCCCCC	27.03	25332170
804	Phosphorylation	SSHHAQATPRWRYNK CCCCCCCCCCCCCCC	10.99	23312004
809	Phosphorylation	QATPRWRYNKPLPPT CCCCCCCCCCCCCCC	22.15	27642862
816	Phosphorylation	YNKPLPPTPDLPQPH CCCCCCCCCCCCCCC	27.74	25159151
828	Phosphorylation	QPHLPPISAPGSSRI CCCCCCCCCCCCCCC	33.90	27251275
832	Phosphorylation	PPISAPGSSRIYRPL CCCCCCCCCCCCCCC	18.51	28348404
833	Phosphorylation	PISAPGSSRIYRPLP CCCCCCCCCCCCCCC	28.72	28348404
836	Phosphorylation	APGSSRIYRPLPPLP CCCCCCCCCCCCCCC	12.69	21945579
849	Phosphorylation	LPIIDPPTEPPPLPP CCCCCCCCCCCCCCC	67.52	-
858	Phosphorylation	PPPLPPKSRGRSRST CCCCCCCCCCCCCCC	45.82	20068231
862	Phosphorylation	PPKSRGRSRSTRGGH CCCCCCCCCCCCCCC	33.15	20068231
866	Asymmetric dimethylarginine	RGRSRSTRGGHMNSG CCCCCCCCCCCCCCC	50.79	-
866	Methylation	RGRSRSTRGGHMNSG CCCCCCCCCCCCCCC	50.79	24129315
878	Phosphorylation	NSGGHAKTRPACQDW CCCCCCCCCCCCCCC	42.54	28348404
886	Phosphorylation	RPACQDWTVPLPASA CCCCCCCCEECCCCC	22.12	23312004
892	Phosphorylation	WTVPLPASAGRTSWP CCEECCCCCCCCCCC	29.35	23312004
896	Phosphorylation	LPASAGRTSWPPATA CCCCCCCCCCCCCCC	33.94	26657352
897	Phosphorylation	PASAGRTSWPPATAR CCCCCCCCCCCCCCC	35.90	26657352
902	Phosphorylation	RTSWPPATARSTESF CCCCCCCCCCCCCCC	28.51	27794612
905	Phosphorylation	WPPATARSTESFTST CCCCCCCCCCCCCCC	33.78	23312004
906	Phosphorylation	PPATARSTESFTSTS CCCCCCCCCCCCCCC	30.05	23312004
908	Phosphorylation	ATARSTESFTSTSRS CCCCCCCCCCCCCCC	33.63	28857561
910	Phosphorylation	ARSTESFTSTSRSKS CCCCCCCCCCCCCCC	40.13	23312004
911	Phosphorylation	RSTESFTSTSRSKSE CCCCCCCCCCCCCCC	23.52	23312004
912	Phosphorylation	STESFTSTSRSKSEV CCCCCCCCCCCCCCC	25.71	23312004
913	Phosphorylation	TESFTSTSRSKSEVS CCCCCCCCCCCCCCC	34.03	23312004
915	Phosphorylation	SFTSTSRSKSEVSPG CCCCCCCCCCCCCCC	40.06	28348404
917	Phosphorylation	TSTSRSKSEVSPGMA CCCCCCCCCCCCCCC	44.47	28348404
920	Phosphorylation	SRSKSEVSPGMAFSN CCCCCCCCCCCCCCC	16.22	28348404
935	Phosphorylation	MTNFLCPSSPTTPWT CCCCCCCCCCCCCCC	48.21	28348404
936	Phosphorylation	TNFLCPSSPTTPWTP CCCCCCCCCCCCCCH	16.06	28348404
938	Phosphorylation	FLCPSSPTTPWTPEL CCCCCCCCCCCCHHH	47.65	28348404
939	Phosphorylation	LCPSSPTTPWTPELQ CCCCCCCCCCCHHHC	21.88	28348404
971	Phosphorylation	AREPLRRTTPQQGAS CCCCCCCCCCCCCCC	36.07	23927012
972	Phosphorylation	REPLRRTTPQQGASG CCCCCCCCCCCCCCC	19.79	25159151
978	Phosphorylation	TTPQQGASGPGRSPV CCCCCCCCCCCCCCC	52.96	28152594
983	Phosphorylation	GASGPGRSPVGQARQ CCCCCCCCCCCCCCC	29.83	25159151
1003	Phosphorylation	HLHLEKASSWPHRRD CCCCCCCCCCCCCCC	43.96	27273156
1004	Phosphorylation	LHLEKASSWPHRRDS CCCCCCCCCCCCCCC	49.87	28188228
1011	Phosphorylation	SWPHRRDSGRPPGDS CCCCCCCCCCCCCCC	34.58	27273156
1018	Phosphorylation	SGRPPGDSSGQAVAP CCCCCCCCCCCCCCC	42.13	23927012
1019	Phosphorylation	GRPPGDSSGQAVAPS CCCCCCCCCCCCCCC	39.40	23927012
1036	Phosphorylation	ANKHKGWSRQGLRRP CCCCCCCCCCCCCCC	24.32	24719451
1044	Phosphorylation	RQGLRRPSILPEGSS CCCCCCCCCCCCCCC	34.64	27273156
1050	Phosphorylation	PSILPEGSSDSRGPA CCCCCCCCCCCCCCC	29.34	25404012
1051	Phosphorylation	SILPEGSSDSRGPAV CCCCCCCCCCCCCCC	50.92	25404012
1060	Ubiquitination	SRGPAVEKHPGPSDT CCCCCCCCCCCCCCC	48.80	21906983
1060 (in isoform 1)	Ubiquitination	-	48.80	21906983
1083	Phosphorylation	KEVMGGFSRRCSKLI HHHCCCHHHHHHHHH	23.30	29514088
1087	Phosphorylation	GGFSRRCSKLINSSQ CCHHHHHHHHHCHHH	28.78	27259358
1092	Phosphorylation	RCSKLINSSQLLYQE HHHHHHCHHHHHHHH	16.68	27642862
1093	Phosphorylation	CSKLINSSQLLYQEY HHHHHCHHHHHHHHH	21.99	27762562
1097	Phosphorylation	INSSQLLYQEYSDVV HCHHHHHHHHHHHHH	14.11	25159151
1099	Phosphorylation	SSQLLYQEYSDVVLN HHHHHHHHHHHHHHC	33.19	17016520
1100	Phosphorylation	SQLLYQEYSDVVLNK HHHHHHHHHHHHHCH	8.47	18180459
1101	Phosphorylation	QLLYQEYSDVVLNKE HHHHHHHHHHHHCHH	24.15	27642862
1107	Ubiquitination	YSDVVLNKEIQSQQR HHHHHHCHHHHHHHH	52.62	21906983
1107 (in isoform 1)	Ubiquitination	-	52.62	21906983
1117	Phosphorylation	QSQQRLESLSETPGP HHHHHHHHHHCCCCC	41.61	20873877
1119	Phosphorylation	QQRLESLSETPGPSS HHHHHHHHCCCCCCC	49.02	23927012
1121	Phosphorylation	RLESLSETPGPSSPR HHHHHHCCCCCCCCC	30.12	23927012
1125	Phosphorylation	LSETPGPSSPRQPRK HHCCCCCCCCCCCCC	59.91	29255136
1126	Phosphorylation	SETPGPSSPRQPRKA HCCCCCCCCCCCCCE	27.51	29255136
1132	Ubiquitination	SSPRQPRKALVSSES CCCCCCCCEECCCHH	53.40	27667366
1136	Phosphorylation	QPRKALVSSESYLQR CCCCEECCCHHHHHH	29.28	25394399
1137	Phosphorylation	PRKALVSSESYLQRL CCCEECCCHHHHHHH	24.07	28348404
1139	Phosphorylation	KALVSSESYLQRLSM CEECCCHHHHHHHHH	32.84	28355574
1140	Phosphorylation	ALVSSESYLQRLSMA EECCCHHHHHHHHHC	11.64	19534553
1145	Phosphorylation	ESYLQRLSMASSGSL HHHHHHHHHCCCCCC	17.94	28857561
1148	Phosphorylation	LQRLSMASSGSLWQE HHHHHHCCCCCCHHC	26.96	24850871
1149	Phosphorylation	QRLSMASSGSLWQEI HHHHHCCCCCCHHCC	23.90	24850871
1151	Phosphorylation	LSMASSGSLWQEIPV HHHCCCCCCHHCCCC	28.51	28857561
1162	Phosphorylation	EIPVVRNSTVLLSMT CCCCEECCEEEEECC	14.88	23312004
1163	Phosphorylation	IPVVRNSTVLLSMTH CCCEECCEEEEECCC	20.79	23312004
1167	Phosphorylation	RNSTVLLSMTHEDQK ECCEEEEECCCCCHH	19.92	29978859
1169	Phosphorylation	STVLLSMTHEDQKLQ CEEEEECCCCCHHHH	20.81	29978859
1188	Phosphorylation	ELIVSEASYLRSLNI EEEECCHHHHHHCCE	22.20	22496350
1189	Phosphorylation	LIVSEASYLRSLNIA EEECCHHHHHHCCEE	17.12	-
1273	Phosphorylation	PYVTNQTYQERTFQS CCCCCCCHHHHHHHH	9.90	27811184
1277	Phosphorylation	NQTYQERTFQSLMNS CCCHHHHHHHHHHHC	25.85	-
1280	Phosphorylation	YQERTFQSLMNSNSN HHHHHHHHHHHCCCC	25.95	-
1284	Phosphorylation	TFQSLMNSNSNFREV HHHHHHHCCCCHHHH	27.89	-
1286	Phosphorylation	QSLMNSNSNFREVLE HHHHHCCCCHHHHHH	36.85	-
1329	Ubiquitination	LLLQNILKRTQPGSS HHHHHHHHHCCCCCH	49.99	23503661
1343	Ubiquitination	SEEAEATKAHHALEQ HHHHHHHHHHHHHHH	53.42	22817900
1343 (in isoform 1)	Ubiquitination	-	53.42	21906983
1370	Phosphorylation	RRTEELIYLSQKIEF HHHHHHHHHHHHEEE	16.96	25159151
1372	Phosphorylation	TEELIYLSQKIEFEC HHHHHHHHHHEEEEE	16.68	28102081
1394	Phosphorylation	QSRWLVKSGELTALE CCCEEECCCCEEEEE	29.98	20068231
1398	Phosphorylation	LVKSGELTALEFSAS EECCCCEEEEEEECC	25.54	23927012
1403	Phosphorylation	ELTALEFSASPGLRR CEEEEEEECCCCHHH	20.61	29255136
1405	Phosphorylation	TALEFSASPGLRRKL EEEEEECCCCHHHHC	20.50	29255136
1446	Phosphorylation	VFDHAPFSSIRGEKC EEECCCHHHHCCCCC	24.64	28857561
1447	Phosphorylation	FDHAPFSSIRGEKCE EECCCHHHHCCCCCE	19.38	28857561
1473	Phosphorylation	RLFLRQNTQGAQAEF HHHHHHCCCCCCEEE	21.75	28857561
1540	Phosphorylation	KADVVMVTQQSSDGW HCCEEEEEECCCCCC	11.64	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARHG5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARHG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARHG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CHSS2_HUMAN	CHPF	physical	21988832
AT131_HUMAN	ATP13A1	physical	21988832
CCNE1_HUMAN	CCNE1	physical	21988832
CRKL_HUMAN	CRKL	physical	21988832
GRB2_HUMAN	GRB2	physical	21988832
NR4A1_HUMAN	NR4A1	physical	21988832
SPS2_HUMAN	SEPHS2	physical	21988832
FKBP8_HUMAN	FKBP8	physical	21988832
CACO2_HUMAN	CALCOCO2	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
HBAP1_HUMAN	HSPBAP1	physical	25416956
EFHC2_HUMAN	EFHC2	physical	25416956
EFHC2_HUMAN	EFHC2	physical	21516116
SHC1_HUMAN	SHC1	physical	24189400
GRB2_HUMAN	GRB2	physical	24189400

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARHG5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-184; SER-445;SER-450 AND SER-1126, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1126, AND MASSSPECTROMETRY.	18691976 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-641; TYR-656; TYR-1097;TYR-1100; TYR-1140 AND TYR-1370, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-70 AND TYR-1100, ANDMASS SPECTROMETRY.	17389395 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1370, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1097 AND TYR-1100, ANDMASS SPECTROMETRY.	15951569 [Abstract]