PHEX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHEX_HUMAN
• UniProt AC: P78562
• Protein Name: Phosphate-regulating neutral endopeptidase
• Gene Name: PHEX
• Organism: Homo sapiens (Human).
• Sequence Length: 749
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Probably involved in bone and dentin mineralization and renal phosphate reabsorption..
• Protein Sequence: MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEAETGSSVETG ---CCCCCCCCHHHC	49.78	-
7	Phosphorylation	-MEAETGSSVETGKK -CCCCCCCCHHHCCC	38.33	-
8	Phosphorylation	MEAETGSSVETGKKA CCCCCCCCHHHCCCC	25.89	-
11	Phosphorylation	ETGSSVETGKKANRG CCCCCHHHCCCCCCC	52.74	-
71	N-linked_Glycosylation	AAILSKVNLSVDPCD HHHHHHCCCCCCCCC	30.27	UniProtKB CARBOHYD
129	Phosphorylation	SISRRRDTEAIQKAK HHHCCCCHHHHHHHH	26.04	-
140	Phosphorylation	QKAKILYSSCMNEKA HHHHHHHHHHCCHHH	17.39	-
141	Phosphorylation	KAKILYSSCMNEKAI HHHHHHHHHCCHHHH	12.11	-
186	Phosphorylation	VWSERKFSLLQTLAT CCCHHHHHHHHHHHH	31.07	-
190	Phosphorylation	RKFSLLQTLATFRGQ HHHHHHHHHHHHCCC	20.52	18491316
193	Phosphorylation	SLLQTLATFRGQYSN HHHHHHHHHCCCCCC	19.58	18491316
238	N-linked_Glycosylation	VREDYLDNSTEAKSY HCHHHCCCCCCHHHH	48.51	UniProtKB CARBOHYD
263	N-linked_Glycosylation	TAVLLGANSSRAEHD HHHHHCCCCCCCCCC	38.43	UniProtKB CARBOHYD
290	N-linked_Glycosylation	EIMIPHENRTSEAMY EEECCCCCCCCHHHH	49.88	UniProtKB CARBOHYD
293	Phosphorylation	IPHENRTSEAMYNKM CCCCCCCCHHHHHCC	21.81	24275569
297	Phosphorylation	NRTSEAMYNKMNISE CCCCHHHHHCCCHHH	20.76	24275569
301	N-linked_Glycosylation	EAMYNKMNISELSAM HHHHHCCCHHHHHHH	35.92	UniProtKB CARBOHYD
346	Phosphorylation	VVVRVPQYFKDLFRI EEEECCHHHHHHHHH	13.41	-
356	Phosphorylation	DLFRILGSERKKTIA HHHHHHCCCHHHHHH	30.68	24043423
377	N-linked_Glycosylation	MVYSRIPNLSRRFQY HHHHCCCCHHHHHHH	48.56	UniProtKB CARBOHYD
484	N-linked_Glycosylation	GYPEFIMNDTHVNED CCCHHHCCCCCCCCC	46.33	UniProtKB CARBOHYD
623	Phosphorylation	KCMINQYSNYYWKKA HHHHHHCCCCCHHHC	14.48	27251275
639	Phosphorylation	LNVKGKRTLGENIAD CCCCCCEECCCCCCC	42.47	-
736	N-linked_Glycosylation	KAFNCPPNSTMNRGM HHHCCCCCCCCCCCC	34.94	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHEX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHEX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHEX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NNRD_HUMAN	CARKD	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00214: Hypophosphatemic rickets, including: X-Linked dominant hypophosphatemia (XLH); X-Linked recessive hy
• OMIM Disease
• 307800: Hypophosphatemic rickets, X-linked dominant (XLHR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.