NEUL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUL4_MOUSE
• UniProt AC: Q5NCX5
• Protein Name: Neuralized-like protein 4
• Gene Name: Neurl4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1563
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
• Protein Description: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity)..
• Protein Sequence: MAAGSGGSGGSGAGPGPGPGPGGGGGPGSSGPGLGSGGGLGGGGELHPRTGRLVSLSACGRTARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVNGRDCGVAATGLPARVWAVVDLYGKCTQITVLPSEPGFSPPTPVPTPPLEPLAPPEDSALLEQGTSVDEAFMVSPAQARPETFPNSLDSHNDFASMELSEVVSNAILSAYNGGLLNVSLSSPPAGDGLASSGPATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDRLRRNNAILRALSPEGALRRAAPAAQAEPERLLFHPNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQATIVDDVEVPPVSEPLPEGNNQMSPSSPSSAAGGSDLRFHQLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTDIDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATSNTATEKSFPLHSPVAGVAHRFHSMCGKNVTLEEDGTRAVRVAGYAHGLVFSTKELKAEEVFEVKVEELDEKWAGSLRLGLTTLAPEDMGPGAGSGPGLPPSLPELRTKTTWMVSSCEVRRDGHLQRMNYGRNLERLGVGSRVGIRRCADDTMHILVDGEDMGPAAAGIAKNVWAVLDLYGPVRSVAIVSSTRLEEPEGTQPPSPSSDTGSEVEEDDEVEEQGLRGQNQVGIVPTALEFLENHGKNILLSNGNRTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALKRAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTIVSPDPGTASGKIAGTQGDMEKADMVDGIKESVCWGPPPAASPLKSCEYHALCSRFQELLLLPEDYFMPPPKRSLCYCESCRKLRGDEAHRRRGEPPREYALPFGWCRFNLRVNPHLEAGTLTKKWHMAYHGSSVAVVRRVLDRGELGAGTTSILSCRPLKGEPGVGFEEPGENCAPPREEQPPPVLLSPSLQYAGAEMLASKVQFRDPKSQRTHQAQVAFQVCVRPGSYTPGPPSAALRELPDQHFSPSELEWVTKEKGATLLYALLVRVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	PRTGRLVSLSACGRT CCCCCEEEEECCCCC	22.62	28066266
57	Phosphorylation	TGRLVSLSACGRTAR CCCEEEEECCCCCCC	17.63	28066266
168	Phosphorylation	VGVERTATGELRLWV EEEEEECCCCEEEEE	30.49	28285833
504	Phosphorylation	NAILRALSPEGALRR CHHHHHHCHHHHHHH	21.66	23527152
635	Ubiquitination	GHNLDRLKAGDTVGV CCCHHHCCCCCEEEE	51.74	22790023
770	Ubiquitination	LFEIVIQKMVDRWSG HHHHHHHHHHHHCCC	29.75	-
798	Phosphorylation	LEFPNTMTDIDYDTW CCCCCCCCCCCHHCC	27.97	-
818	Phosphorylation	AIMQDGNTMRNNYGC EEECCCCCCCCCCCC	24.04	-
843	Ubiquitination	IGMMRTAKGDLHYFI EEEEEECCCCEEEEE	52.96	22790023
904	Phosphorylation	SNTATEKSFPLHSPV CCCCCCCCCCCCCCC	26.34	22324799
909	Phosphorylation	EKSFPLHSPVAGVAH CCCCCCCCCCHHHHH	28.84	26824392
1096	Phosphorylation	RLEEPEGTQPPSPSS CCCCCCCCCCCCCCC	35.92	30635358
1100	Phosphorylation	PEGTQPPSPSSDTGS CCCCCCCCCCCCCCC	44.06	25293948
1102	Phosphorylation	GTQPPSPSSDTGSEV CCCCCCCCCCCCCCC	45.22	30482847
1103	Phosphorylation	TQPPSPSSDTGSEVE CCCCCCCCCCCCCCC	42.44	25293948
1105	Phosphorylation	PPSPSSDTGSEVEED CCCCCCCCCCCCCCC	44.55	25293948
1107	Phosphorylation	SPSSDTGSEVEEDDE CCCCCCCCCCCCCHH	40.33	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUL4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUL4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NEUL4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.