TAOK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAOK1_MOUSE
• UniProt AC: Q5F2E8
• Protein Name: Serine/threonine-protein kinase TAO1
• Gene Name: Taok1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1001
• Subcellular Localization: Cytoplasm.
• Protein Description: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity)..
• Protein Sequence: MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNPTGGPGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PSTNRAGSLKDPEIA CCCCCCCCCCCHHHH	31.12	26824392
11	Ubiquitination	TNRAGSLKDPEIAEL CCCCCCCCCHHHHHH	73.30	-
43	Phosphorylation	HGSFGAVYFARDVRT CCCCCCEEEEECCCC	7.32	22817900
88	Phosphorylation	QRIKHPNSIEYKGCY HHCCCCCCCCCCEEE	22.65	26643407
91	Phosphorylation	KHPNSIEYKGCYLRE CCCCCCCCCEEEHHH	15.83	26643407
172	Phosphorylation	VKLADFGSASMASPA EEECCCCCCCCCCCC	19.71	23649490
174	Phosphorylation	LADFGSASMASPANS ECCCCCCCCCCCCCC	19.31	23649490
177	Phosphorylation	FGSASMASPANSFVG CCCCCCCCCCCCCCC	18.86	23649490
181	Phosphorylation	SMASPANSFVGTPYW CCCCCCCCCCCCCCC	24.34	22322096
185	Phosphorylation	PANSFVGTPYWMAPE CCCCCCCCCCCCCCH	14.11	23649490
187	Phosphorylation	NSFVGTPYWMAPEVI CCCCCCCCCCCCHHE	13.98	23737553
277	Ubiquitination	PTSEELLKHMFVLRE CCHHHHHHHHHHHCC	45.72	-
309	Phosphorylation	RELDNLQYRKMKKLL HHHHHHHHHHHHHHH	18.50	29514104
314	Ubiquitination	LQYRKMKKLLFQEAH HHHHHHHHHHHHHHH	47.10	-
414	Phosphorylation	QEEGDPRTRASDPQS CCCCCCCCCCCCCCC	35.66	29472430
417	Phosphorylation	GDPRTRASDPQSPPQ CCCCCCCCCCCCCCC	46.67	25619855
421	Phosphorylation	TRASDPQSPPQVSRH CCCCCCCCCCCHHHC	43.89	27087446
426	Phosphorylation	PQSPPQVSRHKSHYR CCCCCCHHHCHHHHC	24.34	25619855
432	Phosphorylation	VSRHKSHYRNREHFA HHHCHHHHCCHHHHH	19.37	29514104
440	Phosphorylation	RNREHFATIRTASLV CCHHHHHHHHHHHHH	15.28	26824392
443	Phosphorylation	EHFATIRTASLVTRQ HHHHHHHHHHHHHHH	19.42	22817900
445	Phosphorylation	FATIRTASLVTRQMQ HHHHHHHHHHHHHHH	23.82	25521595
448	Phosphorylation	IRTASLVTRQMQEHE HHHHHHHHHHHHHHH	22.07	22324799
458	Phosphorylation	MQEHEQDSELREQMS HHHHHHCHHHHHHHH	37.92	25338131
465	Phosphorylation	SELREQMSGYKRMRR HHHHHHHHHHHHHHH	38.37	25338131
480	Phosphorylation	QHQKQLMTLENKLKA HHHHHHHHHHHHHHH	39.24	25521595
575	Phosphorylation	EELNENQSTPKKEKQ HHHHHCCCCCHHHHH	59.25	25619855
576	Phosphorylation	ELNENQSTPKKEKQE HHHHCCCCCHHHHHH	29.39	25619855
610	Phosphorylation	LLRRQRQYLELECRR HHHHHHHHHHHHHHH	12.34	29514104
669	Phosphorylation	LEFRHLNTIQKMRCE HHHHHHHHHHHHHHH	31.01	29899451
818	Ubiquitination	LLNAYQSKIKMQAEA HHHHHHHHHHHHHHH	30.71	-
958	Phosphorylation	MQGVPRGSSMGVRNS CCCCCCCCCCCCCCC	20.59	26643407
959	Phosphorylation	QGVPRGSSMGVRNSP CCCCCCCCCCCCCCH	23.52	26643407
965	Phosphorylation	SSMGVRNSPQALRRT CCCCCCCCHHHHHHH	14.07	25521595
972	Phosphorylation	SPQALRRTASGGRTE CHHHHHHHCCCCCCC	20.81	29550500
974	Phosphorylation	QALRRTASGGRTEQG HHHHHHCCCCCCCCC	40.96	25266776
978	Phosphorylation	RTASGGRTEQGMSRS HHCCCCCCCCCCCCC	35.62	29550500
983	Phosphorylation	GRTEQGMSRSTSVTS CCCCCCCCCCEEECC	29.88	29514104
985	Phosphorylation	TEQGMSRSTSVTSQI CCCCCCCCEEECCCC	20.09	30635358
986	Phosphorylation	EQGMSRSTSVTSQIS CCCCCCCEEECCCCC	26.55	30635358
987	Phosphorylation	QGMSRSTSVTSQISN CCCCCCEEECCCCCC	25.33	23684622
989	Phosphorylation	MSRSTSVTSQISNGS CCCCEEECCCCCCCC	18.06	30635358
990	Phosphorylation	SRSTSVTSQISNGSH CCCEEECCCCCCCCC	24.30	30635358
993	Phosphorylation	TSVTSQISNGSHMSY EEECCCCCCCCCCCC	27.74	22006019
996	Phosphorylation	TSQISNGSHMSYT-- CCCCCCCCCCCCC--	21.92	25338131
999	Phosphorylation	ISNGSHMSYT----- CCCCCCCCCC-----	21.87	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
440	T	Phosphorylation	Kinase	MST3	Q9Y6E0	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAOK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAOK1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAOK1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-965, AND MASSSPECTROMETRY.
PubMed: 19144319

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-421, AND MASSSPECTROMETRY.
PubMed: 17114649