FIS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIS1_MOUSE
• UniProt AC: Q9CQ92
• Protein Name: Mitochondrial fission 1 protein
• Gene Name: Fis1
• Organism: Mus musculus (Mouse).
• Sequence Length: 152
• Subcellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
• Protein Description: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission..
• Protein Sequence: MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAVLNEL -------CHHHHHHC	7.23	-
10	Phosphorylation	AVLNELVSVEDLKNF HHHHHCCCHHHHHHH	32.20	-
20	Ubiquitination	DLKNFERKFQSEQAA HHHHHHHHHHHHHCC	40.32	22790023
23	Phosphorylation	NFERKFQSEQAAGSV HHHHHHHHHHCCCCC	34.51	28066266
29	Phosphorylation	QSEQAAGSVSKSTQF HHHHCCCCCCCCHHH	20.63	30635358
31	Phosphorylation	EQAAGSVSKSTQFEY HHCCCCCCCCHHHHH	23.68	23684622
41	S-nitrosocysteine	TQFEYAWCLVRSKYN HHHHHHHHHHHHHCC	1.59	-
41	S-nitrosylation	TQFEYAWCLVRSKYN HHHHHHHHHHHHHCC	1.59	20925432
41	S-palmitoylation	TQFEYAWCLVRSKYN HHHHHHHHHHHHHCC	1.59	28526873
46	Acetylation	AWCLVRSKYNEDIRR HHHHHHHHCCHHHHH	41.34	23201123
64	Ubiquitination	LLEELLPKGSKEEQR HHHHHCCCCCHHHHH	75.64	22790023
108	Ubiquitination	EPQNNQAKELERLID CCCCHHHHHHHHHHH	53.74	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Marchf5	Q3KNM2	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FIS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.