CDC37_MOUSE - dbPTM
CDC37_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC37_MOUSE
UniProt AC Q61081
Protein Name Hsp90 co-chaperone Cdc37
Gene Name Cdc37
Organism Mus musculus (Mouse).
Sequence Length 379
Subcellular Localization Cytoplasm .
Protein Description Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity)..
Protein Sequence MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVDYSVWD
-------CCCCCCCC		4.70-
2Acetylation------MVDYSVWDH
------CCCCCCCCC		10.73-
4Phosphorylation----MVDYSVWDHIE
----CCCCCCCCCEE		8.1625619855
5Phosphorylation---MVDYSVWDHIEV
---CCCCCCCCCEEC		16.5626239621
13PhosphorylationVWDHIEVSDDEDETH
CCCCEECCCCCCCCC		26.9326824392
19PhosphorylationVSDDEDETHPNIDTA
CCCCCCCCCCCCCHH		55.7625619855
64GlutathionylationCKRKVAECQRKLKEL
HHHHHHHHHHHHHHH		3.2324333276
69UbiquitinationAECQRKLKELEVAES
HHHHHHHHHHHHHHC		64.3922790023
76PhosphorylationKELEVAESDGQVELE
HHHHHHHCCCHHHHH		36.9926525534
102AcetylationEERSWEQKLEDMRKK
HHHHHHHHHHHHHHH		42.1822826441
111AcetylationEDMRKKEKNMPWNVD
HHHHHHHHCCCCCHH		68.3823806337
119PhosphorylationNMPWNVDTLSKDGFS
CCCCCHHHCCCCCCC		28.7522324799
121PhosphorylationPWNVDTLSKDGFSKS
CCCHHHCCCCCCCHH		30.6922324799
122AcetylationWNVDTLSKDGFSKSM
CCHHHCCCCCCCHHH		66.0523806337
128PhosphorylationSKDGFSKSMVNTKPE
CCCCCCHHHCCCCHH		27.1129514104
133UbiquitinationSKSMVNTKPEKAEED
CHHHCCCCHHHCCCC		46.07-
133AcetylationSKSMVNTKPEKAEED
CHHHCCCCHHHCCCC		46.0723806337
141PhosphorylationPEKAEEDSEEAREQK
HHHCCCCCHHHHHHH		40.3923684622
155MalonylationKHKTFVEKYEKQIKH
HHHHHHHHHHHHHHH		54.1032601280
155AcetylationKHKTFVEKYEKQIKH
HHHHHHHHHHHHHHH		54.10-
243MalonylationRQFFTKIKTADHQYM
HHHHHHHHHCCHHHH		38.9426320211
254AcetylationHQYMEGFKYELEAFK
HHHHHHHHHHHHHHH		48.9823236377
261AcetylationKYELEAFKERVRGRA
HHHHHHHHHHHHHHH		52.2222826441
279PhosphorylationIEKAMKEYEEEERKK
HHHHHHHHHHHHHHH		24.1125159016
299PhosphorylationGLDPVEVYESLPEEL
CCCHHHHHHHCHHHH		6.0623984901
301PhosphorylationDPVEVYESLPEELQK
CHHHHHHHCHHHHHH		31.3822942356
308UbiquitinationSLPEELQKCFDVKDV
HCHHHHHHCCCHHHH		49.87-
331UbiquitinationKMDPTDAKYHMQRCI
CCCHHHHHHHHHHHH		38.2022790023
331AcetylationKMDPTDAKYHMQRCI
CCCHHHHHHHHHHHH		38.2022826441
348UbiquitinationGLWVPNSKSGEAKEG
CCCCCCCCCCCCCCC		69.9522790023
353UbiquitinationNSKSGEAKEGEEAGP
CCCCCCCCCCCCCCC		63.05-
378PhosphorylationAGNEKDVSA------
CCCCCCCCC------		38.0924719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC37_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDC37_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC37_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RYK_MOUSERykphysical
19269974
ARAF_HUMANARAFphysical
26496610
HS90A_HUMANHSP90AA1physical
26496610
HS90B_HUMANHSP90AB1physical
26496610
IKKB_HUMANIKBKBphysical
26496610
IKBL1_HUMANNFKBIL1physical
26496610
TBA1A_HUMANTUBA1Aphysical
26496610
NEMO_HUMANIKBKGphysical
26496610
GDF15_HUMANGDF15physical
26496610
WDR6_HUMANWDR6physical
26496610
TRM7_HUMANFTSJ1physical
26496610
LTMD1_HUMANLETMD1physical
26496610
RM42_HUMANMRPL42physical
26496610
STX18_HUMANSTX18physical
26496610
E41L5_HUMANEPB41L5physical
26496610
STN1_HUMANOBFC1physical
26496610
DOCK5_HUMANDOCK5physical
26496610
ARG33_HUMANARHGEF33physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC37_MOUSE

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Related Literatures of Post-Translational Modification

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