dbPTM

DOCK5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DOCK5_HUMAN
UniProt AC	Q9H7D0
Protein Name	Dedicator of cytokinesis protein 5
Gene Name	DOCK5
Organism	Homo sapiens (Human).
Sequence Length	1870
Subcellular Localization	Cytoplasm . Cell membrane . Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen.
Protein Description	Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. [PubMed: 19004829]
Protein Sequence	MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTIALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIALLQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVVSTSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSENRISKFKRKDWSLSKSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQSTPLSPPPLTPKATRTLSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPPPPPPKARKSGIPTSEPGSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	RGYTLQNKSKKGIFP HCCCCCCCCCCCCCC	51.17	-
56	Malonylation	TLQNKSKKGIFPETY CCCCCCCCCCCCHHE	65.41	26320211
63	Phosphorylation	KGIFPETYIHLKEAT CCCCCHHEEEEEEEE	5.67	27642862
106	Phosphorylation	AVIWRKLYVNNKLTL HHHHHHHHHCCHHHH	12.27	-
121	Phosphorylation	FRQLQQMTYSLIEWR HHHHHHHHHHHHHHH	12.96	20068231
122	Phosphorylation	RQLQQMTYSLIEWRS HHHHHHHHHHHHHHH	8.99	20068231
123	Phosphorylation	QLQQMTYSLIEWRSQ HHHHHHHHHHHHHHH	17.44	28464451
129	Phosphorylation	YSLIEWRSQILSGTL HHHHHHHHHHHHCCC	23.73	28464451
133	Phosphorylation	EWRSQILSGTLPKDE HHHHHHHHCCCCHHH	31.21	20068231
135	Phosphorylation	RSQILSGTLPKDELA HHHHHHCCCCHHHHH	36.19	20068231
145	Ubiquitination	KDELAELKKKVTAKI HHHHHHHHHHHEEEE	41.89	-
151	Ubiquitination	LKKKVTAKIDHGNRM HHHHHEEEECCCCCE	39.02	-
185	Ubiquitination	TSTIALFKAHEVASK CHHHHHHHHHHHHHH	50.08	-
202	Ubiquitination	EEKIQEEKSILQNLD HHHHHHHHHHHHCCC	41.88	-
342	Ubiquitination	GKVDDEEKQHFIPFQ CCCCHHHHHHCCCHH	47.20	-
365	Phosphorylation	RQRQLIMSPLITSHV HHHHHHCCHHHHHHC	15.01	21712546
369	Phosphorylation	LIMSPLITSHVIGEN HHCCHHHHHHCCCCC	22.06	28450419
370	Phosphorylation	IMSPLITSHVIGENE HCCHHHHHHCCCCCC	14.57	28450419
390	Ubiquitination	LNKVIAAKEVNHKGQ HHHHHHHHHCCCCCC	53.85	-
395	Ubiquitination	AAKEVNHKGQGLWVS HHHHCCCCCCCEEEE	47.96	-
415	Ubiquitination	GDLTQVQKNFSHLVD CCHHHHHHHHHHHHC	62.19	-
418	Phosphorylation	TQVQKNFSHLVDRST HHHHHHHHHHHCHHH	25.88	28270605
482	Ubiquitination	EEGKLLEKAIHPGAG CCCCCHHHHCCCCCC	53.24	-
497	Acetylation	YEGISEYKSVVYYQV CCCHHHCCEEEEEEE	32.49	26051181
573	Ubiquitination	RHDLVVYKGDNKKME CCEEEEEECCCCCEE	48.45	-
604	Ubiquitination	EKELQASKNLVTFTP HHHHHHCCCEEEECC	58.26	-
608	Phosphorylation	QASKNLVTFTPSKDS HHCCCEEEECCCCCC	25.59	29396449
610	Phosphorylation	SKNLVTFTPSKDSTK CCCEEEECCCCCCCC	19.79	25159151
612	Phosphorylation	NLVTFTPSKDSTKDS CEEEECCCCCCCCCH	46.14	29396449
615	Phosphorylation	TFTPSKDSTKDSFQI EECCCCCCCCCHHHH	40.88	23186163
616	Phosphorylation	FTPSKDSTKDSFQIA ECCCCCCCCCHHHHH	49.34	23186163
619	Phosphorylation	SKDSTKDSFQIATLI CCCCCCCHHHHHHHH	22.17	-
624	Phosphorylation	KDSFQIATLICSTKL CCHHHHHHHHHCCCC	20.48	-
645	Phosphorylation	LGLLNWRSNSQNIKH HHHHCCCCCCHHHHH	32.23	27174698
647	Phosphorylation	LLNWRSNSQNIKHNL HHCCCCCCHHHHHHH	26.33	27174698
651	Ubiquitination	RSNSQNIKHNLKKLM CCCCHHHHHHHHHHH	33.71	-
818	Acetylation	KIKGAALKYLPSIIN HHCHHHHHHHHHHHC	39.76	19608861
818	Ubiquitination	KIKGAALKYLPSIIN HHCHHHHHHHHHHHC	39.76	19608861
819	Phosphorylation	IKGAALKYLPSIIND HCHHHHHHHHHHHCC	25.37	24114839
822	Phosphorylation	AALKYLPSIINDVKL HHHHHHHHHHCCEEE	33.24	24114839
856	Ubiquitination	DNQLVRQKLNCMTKI CHHHHHHHHHHHHHH	30.97	-
999	Ubiquitination	MFKDLIGKNVYAKDW HHHHHCCCCCCCCCC	35.92	-
1019	Dimethylation	TQNRVFLRAINQFAE CCCHHHHHHHHHHHH	23.20	-
1124	Phosphorylation	EVELRKATIPIFFDM CHHHHHCCCCEEEEE	30.26	24043423
1139	Phosphorylation	MQCEFNFSGNGNFHM ECCEEECCCCCCEEE	32.24	24043423
1153	Phosphorylation	MFENELITKLDQEVE EEECEEHHHHHHHHC	37.87	24043423
1169	Ubiquitination	GRGDEQYKVLLEKLL CCCHHHHHHHHHHHH	26.54	-
1198	Phosphorylation	EVFALLVSSLLENLL HHHHHHHHHHHHHHC	18.42	-
1222	Phosphorylation	ESKENRMSCTVNVLN CCHHHHHCCEEEHHH	11.91	22496350
1224	Phosphorylation	KENRMSCTVNVLNFY HHHHHCCEEEHHHHH	14.07	-
1246	Ubiquitination	IYIRYLYKLRDLHRD HHHHHHHHHHHHHHC	34.16	-
1287	Phosphorylation	PHLLQKDSYYVYTQQ HHHHCCCCEEEEEHH	25.96	21945579
1288	Phosphorylation	HLLQKDSYYVYTQQE HHHCCCCEEEEEHHH	13.69	21945579
1289	Phosphorylation	LLQKDSYYVYTQQEL HHCCCCEEEEEHHHH	7.31	21945579
1291	Phosphorylation	QKDSYYVYTQQELKE CCCCEEEEEHHHHHH	5.23	21945579
1292	Phosphorylation	KDSYYVYTQQELKEK CCCEEEEEHHHHHHH	17.46	21945579
1316	Ubiquitination	DKGKMWEKAIKLSKE HHCHHHHHHHHHHHH	39.64	-
1322	Ubiquitination	EKAIKLSKELAETYE HHHHHHHHHHHHHHH	68.15	-
1331	Ubiquitination	LAETYESKVFDYEGL HHHHHHHHCCCHHCH	34.67	-
1343	Ubiquitination	EGLGNLLKKRASFYE HCHHHHHHHHHHHHH	43.30	-
1347	Phosphorylation	NLLKKRASFYENIIK HHHHHHHHHHHHHHH	32.18	25159151
1349	Phosphorylation	LKKRASFYENIIKAM HHHHHHHHHHHHHHH	12.93	28152594
1395	Phosphorylation	YERREDFSLRLLTQF CCCCCCCCHHHHHCC	25.54	-
1407	Ubiquitination	TQFPNAEKMTSTTPP HCCCCHHHCCCCCCC	45.10	-
1409	Phosphorylation	FPNAEKMTSTTPPGE CCCHHHCCCCCCCCC	33.71	27732954
1410	Phosphorylation	PNAEKMTSTTPPGED CCHHHCCCCCCCCCC	27.13	27732954
1411	Phosphorylation	NAEKMTSTTPPGEDI CHHHCCCCCCCCCCC	33.87	27732954
1412	Phosphorylation	AEKMTSTTPPGEDIK HHHCCCCCCCCCCCC	27.53	21815630
1444	Ubiquitination	LPPSYKDKPVPEQIL CCCCCCCCCCCHHHH	43.70	-
1453	Phosphorylation	VPEQILNYYRANEVQ CCHHHHHHHHHCCCH	7.29	28634298
1454	Phosphorylation	PEQILNYYRANEVQQ CHHHHHHHHHCCCHH	11.37	28634298
1574	Ubiquitination	EKAFFTEKYLQEHPE HHHHHHHHHHHHCCC	48.48	-
1585	Ubiquitination	EHPEDQEKVELLKRL HCCCHHHHHHHHHHH	35.06	-
1601	Phosphorylation	ALQMPLLTEGIRIHG HHHCHHHCCCCCCCH	39.59	-
1616	Ubiquitination	EKLTEQLKPLHERLS HHHHHHHHHHHHHHH	45.27	-
1637	Phosphorylation	KEKVEKHYGVITLPP HHHHHHHCEEEECCC	24.93	24719451
1641	Phosphorylation	EKHYGVITLPPNLTE HHHCEEEECCCCCCC	30.70	24719451
1652	Phosphorylation	NLTERKQSRTGSIVL CCCCCCCCCCCCCHH	34.54	29978859
1654	Phosphorylation	TERKQSRTGSIVLPY CCCCCCCCCCCHHHH	40.29	21945579
1656	Phosphorylation	RKQSRTGSIVLPYIM CCCCCCCCCHHHHHH	14.65	21945579
1661	Phosphorylation	TGSIVLPYIMSSTLR CCCCHHHHHHHHHHH	12.70	21945579
1664	Phosphorylation	IVLPYIMSSTLRRLS CHHHHHHHHHHHHEE	15.60	21945579
1665	Phosphorylation	VLPYIMSSTLRRLSI HHHHHHHHHHHHEEC	17.68	21945579
1666	Phosphorylation	LPYIMSSTLRRLSIT HHHHHHHHHHHEECE	19.58	21945579
1671	Phosphorylation	SSTLRRLSITSVTSS HHHHHHEECEEEEEE	23.24	26657352
1673	Phosphorylation	TLRRLSITSVTSSVV HHHHEECEEEEEEEE	17.48	25849741
1674	Phosphorylation	LRRLSITSVTSSVVS HHHEECEEEEEEEEE	23.02	25002506
1676	Phosphorylation	RLSITSVTSSVVSTS HEECEEEEEEEEECC	18.30	24247654
1677	Phosphorylation	LSITSVTSSVVSTSS EECEEEEEEEEECCC	20.98	27080861
1678	Phosphorylation	SITSVTSSVVSTSSN ECEEEEEEEEECCCC	19.71	27080861
1681	Phosphorylation	SVTSSVVSTSSNSSD EEEEEEEECCCCCCC	22.03	27080861
1682	Phosphorylation	VTSSVVSTSSNSSDN EEEEEEECCCCCCCC	25.27	27080861
1683	Phosphorylation	TSSVVSTSSNSSDNA EEEEEECCCCCCCCC	21.73	27080861
1684	Phosphorylation	SSVVSTSSNSSDNAP EEEEECCCCCCCCCC	40.60	27080861
1686	Phosphorylation	VVSTSSNSSDNAPSR EEECCCCCCCCCCCC	40.80	27080861
1687	Phosphorylation	VSTSSNSSDNAPSRP EECCCCCCCCCCCCC	38.85	25002506
1692	Phosphorylation	NSSDNAPSRPGSDGS CCCCCCCCCCCCCCC	49.01	27080861
1696	Phosphorylation	NAPSRPGSDGSILEP CCCCCCCCCCCCHHH	41.29	27080861
1699	Phosphorylation	SRPGSDGSILEPLLE CCCCCCCCCHHHHHH	29.05	27080861
1710	Phosphorylation	PLLERRASSGARVED HHHHHHHHCCCCHHH	27.74	26329039
1711	Phosphorylation	LLERRASSGARVEDL HHHHHHHCCCCHHHC	35.17	26329039
1719	Phosphorylation	GARVEDLSLREENSE CCCHHHCCCCCCCCC	37.39	21815630
1725	Phosphorylation	LSLREENSENRISKF CCCCCCCCCCCHHHC	39.26	21712546
1738	Phosphorylation	KFKRKDWSLSKSQVI HCHHCCCCCCHHHHH	32.66	23403867
1740	Phosphorylation	KRKDWSLSKSQVIAE HHCCCCCCHHHHHHH	25.42	23403867
1741	Ubiquitination	RKDWSLSKSQVIAEK HCCCCCCHHHHHHHH	50.64	-
1742	Phosphorylation	KDWSLSKSQVIAEKA CCCCCCHHHHHHHHC	26.72	23927012
1755	Sulfoxidation	KAPEPDLMSPTRKAQ HCCCCCCCCCCCCCC	6.17	30846556
1756	Phosphorylation	APEPDLMSPTRKAQR CCCCCCCCCCCCCCC	30.34	23401153
1758	Phosphorylation	EPDLMSPTRKAQRPK CCCCCCCCCCCCCCC	37.18	29255136
1766	Phosphorylation	RKAQRPKSLQLMDNR CCCCCCCCCCCCCCC	24.83	29255136
1775	Phosphorylation	QLMDNRLSPFHGSSP CCCCCCCCCCCCCCC	23.45	23927012
1780	Phosphorylation	RLSPFHGSSPPQSTP CCCCCCCCCCCCCCC	30.97	23927012
1781	Phosphorylation	LSPFHGSSPPQSTPL CCCCCCCCCCCCCCC	45.23	23927012
1785	Phosphorylation	HGSSPPQSTPLSPPP CCCCCCCCCCCCCCC	37.45	23927012
1786	Phosphorylation	GSSPPQSTPLSPPPL CCCCCCCCCCCCCCC	24.01	23927012
1789	Phosphorylation	PPQSTPLSPPPLTPK CCCCCCCCCCCCCCC	36.24	29255136
1794	Phosphorylation	PLSPPPLTPKATRTL CCCCCCCCCCCCCCC	28.63	29255136
1798	Phosphorylation	PPLTPKATRTLSSPS CCCCCCCCCCCCCCC	30.25	29514088
1800	Phosphorylation	LTPKATRTLSSPSLQ CCCCCCCCCCCCCCC	27.00	30266825
1802	Phosphorylation	PKATRTLSSPSLQTD CCCCCCCCCCCCCCC	39.32	30266825
1803	Phosphorylation	KATRTLSSPSLQTDG CCCCCCCCCCCCCCC	22.94	30266825
1805	Phosphorylation	TRTLSSPSLQTDGIA CCCCCCCCCCCCCCC	34.75	30266825
1808	Phosphorylation	LSSPSLQTDGIAATP CCCCCCCCCCCCCCC	41.30	30278072
1814	Phosphorylation	QTDGIAATPVPPPPP CCCCCCCCCCCCCCC	18.79	25159151
1824	Phosphorylation	PPPPPPKSKPYEGSQ CCCCCCCCCCCCCCC	44.64	28152594
1827	Phosphorylation	PPPKSKPYEGSQRNS CCCCCCCCCCCCCCC	36.34	28152594
1830	Phosphorylation	KSKPYEGSQRNSTEL CCCCCCCCCCCCCCC	17.64	25159151
1834	Phosphorylation	YEGSQRNSTELAPPL CCCCCCCCCCCCCCC	26.00	29255136
1835	Phosphorylation	EGSQRNSTELAPPLP CCCCCCCCCCCCCCC	38.27	30266825
1860	Phosphorylation	PPPKARKSGIPTSEP CCCCHHHCCCCCCCC	36.08	30266825
1864	Phosphorylation	ARKSGIPTSEPGSQ- HHHCCCCCCCCCCC-	43.75	30266825
1865	O-linked_Glycosylation	RKSGIPTSEPGSQ-- HHCCCCCCCCCCC--	36.12	28657654
1865	Phosphorylation	RKSGIPTSEPGSQ-- HHCCCCCCCCCCC--	36.12	30266825
1869	Phosphorylation	IPTSEPGSQ------ CCCCCCCCC------	43.35	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DOCK5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DOCK5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DOCK5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELMO2_HUMAN	ELMO2	physical	28514442
ZHX2_HUMAN	ZHX2	physical	28514442
AT1A2_HUMAN	ATP1A2	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
ANR54_HUMAN	ANKRD54	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
TGON2_HUMAN	TGOLN2	physical	28514442
AHI1_HUMAN	AHI1	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
GPN2_HUMAN	GPN2	physical	28514442
SPSB3_HUMAN	SPSB3	physical	28514442
CE034_HUMAN	C5orf34	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
HDAC6_HUMAN	HDAC6	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
K0100_HUMAN	KIAA0100	physical	28514442
WDR59_HUMAN	WDR59	physical	28514442
DPYL4_HUMAN	DPYSL4	physical	28514442
METH_HUMAN	MTR	physical	28514442
RN5A_HUMAN	RNASEL	physical	28514442
NOL11_HUMAN	NOL11	physical	28514442
VP13B_HUMAN	VPS13B	physical	28514442
MADD_HUMAN	MADD	physical	28514442
PKHG4_HUMAN	PLEKHG4	physical	28514442
TRI65_HUMAN	TRIM65	physical	28514442
FANCJ_HUMAN	BRIP1	physical	28514442
K0232_HUMAN	KIAA0232	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
UBP19_HUMAN	USP19	physical	28514442
BCAS3_HUMAN	BCAS3	physical	28514442
RB3GP_HUMAN	RAB3GAP1	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
WDR19_HUMAN	WDR19	physical	28514442
SMG8_HUMAN	SMG8	physical	28514442
LRCH2_HUMAN	LRCH2	physical	28514442
PJA1_HUMAN	PJA1	physical	28514442
STIL_HUMAN	STIL	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
PK3CB_HUMAN	PIK3CB	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
KIF1A_HUMAN	KIF1A	physical	28514442
SZT2_HUMAN	SZT2	physical	28514442
KPCD2_HUMAN	PRKD2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DOCK5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-818, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1834, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1756 AND SER-1789, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1766; SER-1789;THR-1794; SER-1834 AND SER-1869, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-1756; SER-1789AND SER-1869, AND MASS SPECTROMETRY.	18691976 [Abstract]