K0100_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K0100_HUMAN
• UniProt AC: Q14667
• Protein Name: Protein KIAA0100
• Gene Name: KIAA0100
• Organism: Homo sapiens (Human).
• Sequence Length: 2235
• Subcellular Localization: Secreted .
• Protein Description: May be involved in membrane trafficking..
• Protein Sequence: MPLFFSALLVLLLVALSALFLGRWLVVRLATKWCQRKLQAELKIGSFRFFWIQNVSLKFQQHQQTVEIDNLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSDLSAPFSQSAGVDQKELSFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLDSDGKRLICEVSLCKINSKVLKSGQLEDTCLVELSLALDLCLKVGISSRHLTAITVDVWTLHAELHEGLFQSQLLCQGPSLASKPVPCSEVTENLVEPTLPGLFLLQQLPDQVKVKMENTSVVLSMNSQKRHLTWTLKLLQFLYHRDEDQLPLRSFTANSDMAQMSTELLLEDGLLLSQSRQRIVCLNSLKASVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHLLALETQGSSSPVLKQRKKRTFPQILAPIIFSTSISNVNISIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGASEVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTRAWASPSPVPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGDKNPGKKSIFGRRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24 (in isoform 3)	Ubiquitination	-	7.54	21906983
46	Phosphorylation	QAELKIGSFRFFWIQ HHHCCCCCEEEEEEE	19.40	24719451
97	Phosphorylation	FGEVRIRTDLQKVSD HCEEEEECCHHHHHH	38.40	-
97	O-linked_Glycosylation	FGEVRIRTDLQKVSD HCEEEEECCHHHHHH	38.40	55824489
103	Phosphorylation	RTDLQKVSDLSAPFS ECCHHHHHHCCCCCH	39.61	-
125	Phosphorylation	KELSFSPSLLKIFCQ HHHCCCHHHHHHHHH	45.17	24719451
216 (in isoform 3)	Ubiquitination	-	29.49	21906983
286	Phosphorylation	VKVKMENTSVVLSMN EEEEEECCEEEEECC	15.02	29978859
287	Phosphorylation	KVKMENTSVVLSMNS EEEEECCEEEEECCC	23.08	29978859
291	Phosphorylation	ENTSVVLSMNSQKRH ECCEEEEECCCCCHH	12.33	29978859
294	Phosphorylation	SVVLSMNSQKRHLTW EEEEECCCCCHHHHH	28.56	29978859
412	Ubiquitination	KQRKKRTFPQILAPI HHHHHCCCHHHHHHH	4.94	22817900
547	Phosphorylation	QCLSRILSLMGPQSG HHHHHHHHHHCCCCC	17.59	29759185
553	Phosphorylation	LSLMGPQSGKSAVSR HHHHCCCCCCCHHHH	51.85	-
555	Ubiquitination	LMGPQSGKSAVSRHS HHCCCCCCCHHHHCC	40.25	21906983
555 (in isoform 2)	Ubiquitination	-	40.25	21906983
555 (in isoform 1)	Ubiquitination	-	40.25	21906983
556	Phosphorylation	MGPQSGKSAVSRHSS HCCCCCCCHHHHCCC	37.11	29759185
559	Phosphorylation	QSGKSAVSRHSSFGE CCCCCHHHHCCCCCC	24.80	29759185
563	Phosphorylation	SAVSRHSSFGESVSL CHHHHCCCCCCCEEE	31.01	-
599	Phosphorylation	ASEVRLDTLTILGSA CCCCCCEEEEEECCC	30.32	22210691
609	Phosphorylation	ILGSAETSTVGIQGL EECCCCCCCCCHHHH	16.76	22210691
639	Phosphorylation	CKAPDIPTPVLSLSM HCCCCCCCCCEEHHH	26.77	-
703	Ubiquitination	VFPETVPSLALETSG CCCCCCCCEEEEECC	23.18	22817900
706	Ubiquitination	ETVPSLALETSGTTS CCCCCEEEEECCCCC	10.02	22817900
730	N-linked_Glycosylation	LPPKRLLNLTLEVST CCCHHHHEEEEEEEC	35.26	UniProtKB CARBOHYD
755	Ubiquitination	KFITLAAESVSLSRH HHHEEEEEEEEECCC	46.17	22817900
756	Phosphorylation	FITLAAESVSLSRHG HHEEEEEEEEECCCC	16.57	24719451
759	Ubiquitination	LAAESVSLSRHGGSL EEEEEEEECCCCCCH	4.97	22817900
760	Phosphorylation	AAESVSLSRHGGSLQ EEEEEEECCCCCCHH	18.09	24719451
771	Ubiquitination	GSLQAYCPELAAGFD CCHHHHCHHHHCCCC	27.28	21963094
777	Ubiquitination	CPELAAGFDGNSIFN CHHHHCCCCCCCCCC	10.49	23503661
816 (in isoform 2)	Ubiquitination	-	4.89	21906983
846	Ubiquitination	DEAVGVQKWLKGLHQ HHHHHHHHHHHCHHC	52.68	21906983
846 (in isoform 1)	Ubiquitination	-	52.68	21906983
849	Ubiquitination	VGVQKWLKGLHQGTR HHHHHHHHCHHCCCC	59.31	22817900
868 (in isoform 2)	Ubiquitination	-	53.19	21906983
878	Phosphorylation	LLKVEHFSWVFLDDV EEEEEEEEEEEECCE	25.00	28450419
884 (in isoform 2)	Ubiquitination	-	49.50	21906983
898	Ubiquitination	HDNYELMKDESKESA CCCCHHCCCCCHHHH	71.60	22817900
898 (in isoform 1)	Ubiquitination	-	71.60	21906983
902	Ubiquitination	ELMKDESKESAKRLQ HHCCCCCHHHHHHHH	54.35	22817900
914	Ubiquitination	RLQLLDAKVAALRKQ HHHHHHHHHHHHHHH	31.88	21906983
914 (in isoform 1)	Ubiquitination	-	31.88	21906983
920	Ubiquitination	AKVAALRKQHGELLP HHHHHHHHHHCCCCC	47.71	23503661
930	Ubiquitination	GELLPARKIEELYAS CCCCCHHHHHHHHHH	57.48	29967540
957	Phosphorylation	SRRLYGNTPMRRALL HHHHHCCCHHHHHHH	17.69	-
1160	Ubiquitination	ATEDPYNTTENMHWE CCCCCCCCCCCCCEE	29.64	23503661
1166	Ubiquitination	NTTENMHWEWSHLSF CCCCCCCEEEEEEEE	9.66	22817900
1169	Ubiquitination	ENMHWEWSHLSFHWK CCCCEEEEEEEEEEC	11.75	22817900
1170	Ubiquitination	NMHWEWSHLSFHWKP CCCEEEEEEEEEECC	26.94	22817900
1171	Ubiquitination	MHWEWSHLSFHWKPG CCEEEEEEEEEECCC	4.96	22817900
1228	Phosphorylation	PHDHHSVTLRAPEFL CCCCCCEEECCCCCC	17.34	24719451
1260	Ubiquitination	ENLNLSIKMDLTRHS CCCCEEEEEECHHCC	24.00	29967540
1267	Phosphorylation	KMDLTRHSGTISQPR EEECHHCCCCCCCCE	34.05	26699800
1269	Phosphorylation	DLTRHSGTISQPRIL ECHHCCCCCCCCEEE	22.07	22496350
1271	Phosphorylation	TRHSGTISQPRILLY HHCCCCCCCCEEEEH	33.69	26699800
1279 (in isoform 2)	Ubiquitination	-	19.47	21906983
1303	Ubiquitination	TRPICRGKLFNNLKP CCCHHCCCCHHCCCC	30.47	23503661
1309	Ubiquitination	GKLFNNLKPSKKKLG CCCHHCCCCCHHHHH	49.74	21906983
1309 (in isoform 1)	Ubiquitination	-	49.74	21906983
1312	Ubiquitination	FNNLKPSKKKLGQHY HHCCCCCHHHHHHHH	63.56	22817900
1313	Ubiquitination	NNLKPSKKKLGQHYK HCCCCCHHHHHHHHH	58.53	22817900
1314	Ubiquitination	NLKPSKKKLGQHYKQ CCCCCHHHHHHHHHH	62.68	22817900
1337	Ubiquitination	QLQVHYWASFAQQRG HHHHHHHHHHHHHHC	6.39	27667366
1384	Phosphorylation	WSVTQMVSDLSQVTV CCHHHHHCCHHHEEE	27.73	-
1384	Ubiquitination	WSVTQMVSDLSQVTV CCHHHHHCCHHHEEE	27.73	23503661
1413	Phosphorylation	LDPLVTKTHLLSLSS CCHHHCHHHHHHHHH	14.37	25907765
1417	Phosphorylation	VTKTHLLSLSSLTYQ HCHHHHHHHHHHHCC	32.34	25907765
1419	Phosphorylation	KTHLLSLSSLTYQRH HHHHHHHHHHHCCCC	21.67	25907765
1420	Phosphorylation	THLLSLSSLTYQRHS HHHHHHHHHHCCCCC	29.98	25907765
1422	Phosphorylation	LLSLSSLTYQRHSNR HHHHHHHHCCCCCCC	21.40	25907765
1423	Phosphorylation	LSLSSLTYQRHSNRT HHHHHHHCCCCCCCC	14.62	25907765
1459	Phosphorylation	VDLRISWTTTNRDIA EEEEEEEEECCCCCE	19.56	23312004
1460	Phosphorylation	DLRISWTTTNRDIAF EEEEEEEECCCCCEE	18.80	23312004
1461	Phosphorylation	LRISWTTTNRDIAFG EEEEEEECCCCCEEE	22.38	23312004
1479	Ubiquitination	GYKKAAVLKRNLSTE CHHHHHHHHHCCCHH	3.55	27667366
1480	Ubiquitination	YKKAAVLKRNLSTEA HHHHHHHHHCCCHHH	32.42	27667366
1484	Phosphorylation	AVLKRNLSTEALKGL HHHHHCCCHHHHCCC	27.96	30266825
1485	Phosphorylation	VLKRNLSTEALKGLK HHHHCCCHHHHCCCC	28.57	30266825
1488	Ubiquitination	RNLSTEALKGLKIDP HCCCHHHHCCCCCCC	3.53	29967540
1489	Methylation	NLSTEALKGLKIDPQ CCCHHHHCCCCCCCC	70.06	115971985
1489	Ubiquitination	NLSTEALKGLKIDPQ CCCHHHHCCCCCCCC	70.06	29967540
1497 (in isoform 2)	Ubiquitination	-	4.19	-
1508	Phosphorylation	KPKRGVPTSASAPPR CCCCCCCCCCCCCCC	34.22	23312004
1509	Phosphorylation	PKRGVPTSASAPPRV CCCCCCCCCCCCCCC	17.73	23403867
1511	Phosphorylation	RGVPTSASAPPRVNT CCCCCCCCCCCCCCC	40.87	23403867
1512	Ubiquitination	GVPTSASAPPRVNTP CCCCCCCCCCCCCCC	20.17	22817900
1518	Phosphorylation	SAPPRVNTPSFSGQP CCCCCCCCCCCCCCC	19.90	25159151
1526	Ubiquitination	PSFSGQPDKGSSGGA CCCCCCCCCCCCHHH	61.12	23503661
1527	Ubiquitination	SFSGQPDKGSSGGAY CCCCCCCCCCCHHHH	68.33	23503661
1529	Phosphorylation	SGQPDKGSSGGAYML CCCCCCCCCHHHHHH	31.39	28122231
1530	Phosphorylation	GQPDKGSSGGAYMLQ CCCCCCCCHHHHHHH	50.33	28122231
1534	Phosphorylation	KGSSGGAYMLQKLIE CCCCHHHHHHHHHHH	11.13	27642862
1619	Ubiquitination	PAWYGDTLKQKTSWT CHHCCCCCCHHCEEE	7.05	29967540
1620	Ubiquitination	AWYGDTLKQKTSWTC HHCCCCCCHHCEEEE	52.41	29967540
1624	Phosphorylation	DTLKQKTSWTCLLDG CCCCHHCEEEEECCC	27.68	28985074
1625 (in isoform 2)	Ubiquitination	-	9.07	21906983
1638	Phosphorylation	GMQYFATTESSPTEQ CEEEEEECCCCCCCC	30.36	28985074
1654	Ubiquitination	GRQLWLEVKNIEEHR CCEEEEEEECHHHHH	5.57	22817900
1655	Ubiquitination	RQLWLEVKNIEEHRQ CEEEEEEECHHHHHH	42.72	22817900
1655 (in isoform 1)	Ubiquitination	-	42.72	21906983
1704	Ubiquitination	AQQVQRIISRCNCRM HHHHHHHHHHCCCEE	2.01	22817900
1817 (in isoform 2)	Ubiquitination	-	4.39	21906983
1836	Phosphorylation	RQLEKQMYSIMKSLQ HHHHHHHHHHHHHCC	7.80	18083107
1837	Phosphorylation	QLEKQMYSIMKSLQD HHHHHHHHHHHHCCC	15.74	28122231
1841	Phosphorylation	QMYSIMKSLQDDSKN HHHHHHHHCCCCCCC	17.55	23186163
1846	Phosphorylation	MKSLQDDSKNENLLD HHHCCCCCCCCCCCH	45.75	25159151
1846	Ubiquitination	MKSLQDDSKNENLLD HHHCCCCCCCCCCCH	45.75	22817900
1847	Ubiquitination	KSLQDDSKNENLLDL HHCCCCCCCCCCCHH	75.24	22817900
1847 (in isoform 1)	Ubiquitination	-	75.24	21906983
1856	Ubiquitination	ENLLDLNQKLQLQLN CCCCHHHHHHHHHHH	55.95	29967540
1857	Ubiquitination	NLLDLNQKLQLQLNQ CCCHHHHHHHHHHHH	36.81	29967540
1904	Phosphorylation	RKQQEDVSVVRRTEF HHHHHCCCHHHHHHE	27.50	24719451
1915	Ubiquitination	RTEFYFAQARWRLTE HHHEEEEEEEEEEEH	22.89	27667366
1977	Phosphorylation	KVVLRPQSSCQSGRQ EEEECCCCCCHHHHH	35.45	30576142
1978	Phosphorylation	VVLRPQSSCQSGRQL EEECCCCCCHHHHHH	15.78	30576142
1981	Phosphorylation	RPQSSCQSGRQLALR CCCCCCHHHHHHHHH	40.03	30576142
1991	Phosphorylation	QLALRLFSKVRPPVG HHHHHHHHCCCCCCC	34.53	24719451
2047	Ubiquitination	VGDEEDKSKLVTTGI CCCHHHHHCEEECCC	43.47	29967540
2048	Ubiquitination	GDEEDKSKLVTTGIP CCHHHHHCEEECCCC	53.36	29967540
2057	Ubiquitination	VTTGIPVVKPRQLIA EECCCCCCCCCCEEE	6.23	27667366
2058	Ubiquitination	TTGIPVVKPRQLIAT ECCCCCCCCCCEEEC	34.42	27667366
2085	Phosphorylation	AQGLTRSSGVRRSFR HHCCCCCCCCHHHHH	37.71	-
2090	Phosphorylation	RSSGVRRSFRKSPEH CCCCCHHHHHCCCCC	20.88	23403867
2094	Phosphorylation	VRRSFRKSPEHPVDD CHHHHHCCCCCCCCC	31.12	29255136
2104	Acetylation	HPVDDIDKMKERAAM CCCCCHHHHHHHHHH	52.81	7825169
2106	Acetylation	VDDIDKMKERAAMNN CCCHHHHHHHHHHCC	50.19	7825179
2117	Phosphorylation	AMNNSFIYIKIPQVP HHCCCEEEEECCCCC	8.31	27251275
2119	Ubiquitination	NNSFIYIKIPQVPLC CCCEEEEECCCCCEE	31.21	-
2170	Acetylation	AVKRDSRKALVAQVI HHCCCCHHHHHHHHH	50.45	19809747
2178	Acetylation	ALVAQVIKEKLRLKS HHHHHHHHHHHHHHC	50.36	19809755
2180	Acetylation	VAQVIKEKLRLKSAT HHHHHHHHHHHHCCC	33.63	19809763
2183	Ubiquitination	VIKEKLRLKSATGSE HHHHHHHHHCCCCCH	8.13	29967540
2184	Ubiquitination	IKEKLRLKSATGSEV HHHHHHHHCCCCCHH	31.45	29967540
2185	Phosphorylation	KEKLRLKSATGSEVR HHHHHHHCCCCCHHH	35.34	23312004
2197	Phosphorylation	EVRGKLETKSDLNMQ HHHHHCCCHHHCCHH	46.41	28355574
2199	Phosphorylation	RGKLETKSDLNMQQQ HHHCCCHHHCCHHHH	55.54	28355574
2203	Sulfoxidation	ETKSDLNMQQQEEEE CCHHHCCHHHHHHHH	5.04	21406390
2210	Ubiquitination	MQQQEEEEKARLLIG HHHHHHHHHHHHHHC	56.12	29967540
2211	Ubiquitination	QQQEEEEKARLLIGL HHHHHHHHHHHHHCC	41.93	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K0100_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K0100_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K0100_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K0100_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1846, AND MASSSPECTROMETRY.
PubMed: 18669648