dbPTM

BCAS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BCAS3_HUMAN
UniProt AC	Q9H6U6
Protein Name	Breast carcinoma-amplified sequence 3 {ECO:0000312\|HGNC:HGNC:14347, ECO:0000312\|MIM:607470}
Gene Name	BCAS3 {ECO:0000312\|HGNC:HGNC:14347, ECO:0000312\|MIM:607470}
Organism	Homo sapiens (Human).
Sequence Length	928
Subcellular Localization	Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motil
Protein Description	Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin..
Protein Sequence	MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPPLLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKSIQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKLIRCHQSRGGACGDNIQSYTATVISAAKTLKSGLTMVGKVVTQLTGTLPSGVTEDDVAIHSNSRRSPLVPGIITVIDTETVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQPCVRTHMSPRVVNRMSRFQKSAGLEEIEQELTSKQGGRCSPVPGLSSSPSGSPLHGKLNSQDSYNNFTNNNPGNPRLSPLPSLMVVMPLAQIKQPMTLGTITKRTGPYLFGAGCFSIKAPCKVKPPPQISPSKSMGGEFCVAAIFGTSRSWFANNAGLKREKDQSKQVVVESLYIISCYGTLVEHMMEPRPLSTAPKISDDTPLEMMTSPRASWTLVRTPQWNELQPPFNANHPLLLAADAVQYYQFLLAGLVPPGSPGPITRHGSYDSLASDHSGQEDEEWLSQVEIVTHTGPHRRLWMGPQFQFKTIHPSGQTTVISSSSSVLQSHGPSDTPQPLLDFDTDDLDLNSLRIQPVRSDPVSMPGSSRPVSDRRGVSTVIDAASGTFDRSVTLLEVCGSWPEGFGLRHMSSMEHTEEGLRERLADAMAESPSRDVVGSGTELQREGSIETLSNSSGSTSGSIPRNFDGYRSPLPTNESQPLSLFPTGFP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNEAMATD -------CCCCCCCC	10.37	22814378
9	Phosphorylation	NEAMATDSPRRPSRC CCCCCCCCCCCCCCC	18.89	29759185
14	Phosphorylation	TDSPRRPSRCTGGVV CCCCCCCCCCCCCEE	37.87	20068231
73	Phosphorylation	ENADLNDTSRNLEFH CCCCCCCCCCCEEEE	28.63	-
97	Phosphorylation	PLLIMIGYSDGMQVW CEEEEEECCCCCEEE	7.83	22210691
98	Phosphorylation	LLIMIGYSDGMQVWS EEEEEECCCCCEEEE	23.60	22210691
105	Phosphorylation	SDGMQVWSIPISGEA CCCCEEEEEEECCCH	21.45	22210691
145	Ubiquitination	KCDNFAEKRPLLGVC CCCCHHHHCCCHHHH	56.75	-
145 (in isoform 8)	Ubiquitination	-	56.75	-
154	Phosphorylation	PLLGVCKSIGSSGTS CCHHHHHHCCCCCCC	27.36	25627689
157	Phosphorylation	GVCKSIGSSGTSPPY HHHHHCCCCCCCCCE	24.75	25627689
158	Phosphorylation	VCKSIGSSGTSPPYC HHHHCCCCCCCCCEE	40.66	25627689
160	Phosphorylation	KSIGSSGTSPPYCCV HHCCCCCCCCCEEEE	39.75	25627689
161	Phosphorylation	SIGSSGTSPPYCCVD HCCCCCCCCCEEEEE	27.66	25627689
171	Phosphorylation	YCCVDLYSLRTGEMV EEEEEEEECCCCCCE	20.76	24719451
180	Phosphorylation	RTGEMVKSIQFKTPI CCCCCEEEEEECCCE	15.37	-
184	Ubiquitination	MVKSIQFKTPIYDLH CEEEEEECCCEEECC	36.70	-
215	Acetylation	FDSCTFTKKFFVTSC CCCCCCEEEEEEEEE	43.31	25953088
215	Malonylation	FDSCTFTKKFFVTSC CCCCCCEEEEEEEEE	43.31	26320211
215	Sumoylation	FDSCTFTKKFFVTSC CCCCCCEEEEEEEEE	43.31	25114211
215	Ubiquitination	FDSCTFTKKFFVTSC CCCCCCEEEEEEEEE	43.31	-
215 (in isoform 8)	Malonylation	-	43.31	26320211
246	Acetylation	WLAYAENKLIRCHQS HHHHHHHCEEEEECC	36.47	30587173
275	Phosphorylation	TVISAAKTLKSGLTM HHHHHHHHHHHCCCH	34.39	-
288	Phosphorylation	TMVGKVVTQLTGTLP CHHHHHHHHHHCCCC	22.35	-
326 (in isoform 6)	Phosphorylation	-	35.58	25849741
328 (in isoform 6)	Phosphorylation	-	40.51	29116813
445	Phosphorylation	GGQPCVRTHMSPRVV CCCCCCCCCCCHHHH	11.09	26437602
448	Phosphorylation	PCVRTHMSPRVVNRM CCCCCCCCHHHHHHH	11.27	26437602
456	Phosphorylation	PRVVNRMSRFQKSAG HHHHHHHHHHHHHCC	27.06	24719451
461	Phosphorylation	RMSRFQKSAGLEEIE HHHHHHHHCCHHHHH	19.45	25159151
472	Phosphorylation	EEIEQELTSKQGGRC HHHHHHHHHCCCCCC	32.88	26074081
473	Phosphorylation	EIEQELTSKQGGRCS HHHHHHHHCCCCCCC	35.29	26074081
474	Ubiquitination	IEQELTSKQGGRCSP HHHHHHHCCCCCCCC	47.96	2190698
474 (in isoform 1)	Ubiquitination	-	47.96	21906983
474 (in isoform 2)	Ubiquitination	-	47.96	21906983
474 (in isoform 3)	Ubiquitination	-	47.96	21906983
480	Phosphorylation	SKQGGRCSPVPGLSS HCCCCCCCCCCCCCC	27.80	23401153
486	Phosphorylation	CSPVPGLSSSPSGSP CCCCCCCCCCCCCCC	34.38	23401153
487	Phosphorylation	SPVPGLSSSPSGSPL CCCCCCCCCCCCCCC	51.84	22167270
488	Phosphorylation	PVPGLSSSPSGSPLH CCCCCCCCCCCCCCC	21.51	23401153
490	Phosphorylation	PGLSSSPSGSPLHGK CCCCCCCCCCCCCCC	54.58	22167270
492	Phosphorylation	LSSSPSGSPLHGKLN CCCCCCCCCCCCCCC	28.73	22167270
500	Phosphorylation	PLHGKLNSQDSYNNF CCCCCCCCCCCCCCC	45.89	23401153
503	Phosphorylation	GKLNSQDSYNNFTNN CCCCCCCCCCCCCCC	23.32	25159151
504	Phosphorylation	KLNSQDSYNNFTNNN CCCCCCCCCCCCCCC	23.55	28450419
508	Phosphorylation	QDSYNNFTNNNPGNP CCCCCCCCCCCCCCC	38.88	28450419
518	Phosphorylation	NPGNPRLSPLPSLMV CCCCCCCCCCCCEEE	26.18	28857561
522	Phosphorylation	PRLSPLPSLMVVMPL CCCCCCCCEEEEEEH	36.46	24043423
555 (in isoform 2)	Phosphorylation	-	9.17	25849741
555 (in isoform 3)	Phosphorylation	-	9.17	25849741
555 (in isoform 7)	Phosphorylation	-	9.17	25849741
557 (in isoform 2)	Phosphorylation	-	1.90	29116813
557 (in isoform 3)	Phosphorylation	-	1.90	29116813
557 (in isoform 7)	Phosphorylation	-	1.90	29116813
570	Phosphorylation	VKPPPQISPSKSMGG CCCCCCCCCCCCCCC	20.20	30266825
572	Phosphorylation	PPPQISPSKSMGGEF CCCCCCCCCCCCCCE	30.48	20873877
574	Phosphorylation	PQISPSKSMGGEFCV CCCCCCCCCCCCEEE	27.31	27251275
599	Ubiquitination	FANNAGLKREKDQSK HHCCCCCCCCCCCCC	58.56	-
614	Phosphorylation	QVVVESLYIISCYGT HHHHEEEEHHHHHHH	12.89	25850435
617	Phosphorylation	VESLYIISCYGTLVE HEEEEHHHHHHHHHH	7.54	25850435
619	Phosphorylation	SLYIISCYGTLVEHM EEEHHHHHHHHHHHH	13.32	25850435
621	Phosphorylation	YIISCYGTLVEHMME EHHHHHHHHHHHHHC	10.93	25850435
648	Phosphorylation	DTPLEMMTSPRASWT CCCCHHHCCCCCCEE	33.98	-
649	Phosphorylation	TPLEMMTSPRASWTL CCCHHHCCCCCCEEE	8.42	-
706	Phosphorylation	GPITRHGSYDSLASD CCCCCCCCHHCCCCC	21.46	30108239
707	Phosphorylation	PITRHGSYDSLASDH CCCCCCCHHCCCCCC	17.72	30108239
709	Phosphorylation	TRHGSYDSLASDHSG CCCCCHHCCCCCCCC	20.01	30108239
712	Phosphorylation	GSYDSLASDHSGQED CCHHCCCCCCCCCCC	40.94	30108239
715	Phosphorylation	DSLASDHSGQEDEEW HCCCCCCCCCCCHHH	47.35	30108239
724	Phosphorylation	QEDEEWLSQVEIVTH CCCHHHHHCEEEEEE	33.00	23312004
730	Phosphorylation	LSQVEIVTHTGPHRR HHCEEEEEECCCCCC	21.27	23312004
732	Phosphorylation	QVEIVTHTGPHRRLW CEEEEEECCCCCCEE	42.94	23312004
801	Phosphorylation	PVRSDPVSMPGSSRP ECCCCCCCCCCCCCC	25.34	28348404
805	Phosphorylation	DPVSMPGSSRPVSDR CCCCCCCCCCCCCCC	19.80	28555341
806	Phosphorylation	PVSMPGSSRPVSDRR CCCCCCCCCCCCCCC	46.66	28555341
816	Phosphorylation	VSDRRGVSTVIDAAS CCCCCCCCCHHHHCC	21.56	29255136
817	Phosphorylation	SDRRGVSTVIDAASG CCCCCCCCHHHHCCC	21.05	29255136
823	Phosphorylation	STVIDAASGTFDRSV CCHHHHCCCCCCCEE	39.83	29255136
825	Phosphorylation	VIDAASGTFDRSVTL HHHHCCCCCCCEEEH	21.62	29255136
829	Phosphorylation	ASGTFDRSVTLLEVC CCCCCCCEEEHHHHH	22.69	22617229
831	Phosphorylation	GTFDRSVTLLEVCGS CCCCCEEEHHHHHCC	27.20	25278378
838	Phosphorylation	TLLEVCGSWPEGFGL EHHHHHCCCCCCCCC	34.04	22617229
849	Phosphorylation	GFGLRHMSSMEHTEE CCCCCCHHHHCCCHH	22.02	23927012
850	Phosphorylation	FGLRHMSSMEHTEEG CCCCCHHHHCCCHHH	22.18	23927012
854	Phosphorylation	HMSSMEHTEEGLRER CHHHHCCCHHHHHHH	23.56	23312004
854 (in isoform 3)	Phosphorylation	-	23.56	25849741
854 (in isoform 7)	Phosphorylation	-	23.56	25849741
856 (in isoform 3)	Phosphorylation	-	65.76	25849741
856 (in isoform 7)	Phosphorylation	-	65.76	25849741
862 (in isoform 3)	Phosphorylation	-	4.30	22199227
862 (in isoform 7)	Phosphorylation	-	4.30	22199227
866	Sulfoxidation	RERLADAMAESPSRD HHHHHHHHHHCCCCC	4.35	21406390
869	Phosphorylation	LADAMAESPSRDVVG HHHHHHHCCCCCCCC	20.73	19664994
869 (in isoform 8)	Phosphorylation	-	20.73	25849741
871	Phosphorylation	DAMAESPSRDVVGSG HHHHHCCCCCCCCCC	50.85	30266825
871 (in isoform 8)	Phosphorylation	-	50.85	25849741
877	Phosphorylation	PSRDVVGSGTELQRE CCCCCCCCCCCEEEE	30.82	20058876
877 (in isoform 8)	Phosphorylation	-	30.82	22199227
879	Phosphorylation	RDVVGSGTELQREGS CCCCCCCCCEEEECC	34.91	29978859
886	Phosphorylation	TELQREGSIETLSNS CCEEEECCEEECCCC	16.70	30266825
889	Phosphorylation	QREGSIETLSNSSGS EEECCEEECCCCCCC	33.54	30266825
891	Phosphorylation	EGSIETLSNSSGSTS ECCEEECCCCCCCCC	41.93	30266825
893	Phosphorylation	SIETLSNSSGSTSGS CEEECCCCCCCCCCC	32.47	30266825
893 (in isoform 3)	Phosphorylation	-	32.47	29507054
894	Phosphorylation	IETLSNSSGSTSGSI EEECCCCCCCCCCCC	40.80	23403867
896	Phosphorylation	TLSNSSGSTSGSIPR ECCCCCCCCCCCCCC	22.73	30266825
897	Phosphorylation	LSNSSGSTSGSIPRN CCCCCCCCCCCCCCC	40.40	29255136
898	Phosphorylation	SNSSGSTSGSIPRNF CCCCCCCCCCCCCCC	32.04	30266825
900	Phosphorylation	SSGSTSGSIPRNFDG CCCCCCCCCCCCCCC	29.23	30266825
908	Phosphorylation	IPRNFDGYRSPLPTN CCCCCCCCCCCCCCC	15.12	27251275
908 (in isoform 8)	Phosphorylation	-	15.12	29507054
910	Phosphorylation	RNFDGYRSPLPTNES CCCCCCCCCCCCCCC	23.46	27251275
914	Phosphorylation	GYRSPLPTNESQPLS CCCCCCCCCCCCCCC	60.34	28122231
917	Phosphorylation	SPLPTNESQPLSLFP CCCCCCCCCCCCCCC	38.89	28348404
921	Phosphorylation	TNESQPLSLFPTGFP CCCCCCCCCCCCCCC	34.35	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BCAS3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BCAS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BCAS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP070_HUMAN	C16orf70	physical	25416956
ESR1_HUMAN	ESR1	physical	17505058
PELP1_HUMAN	PELP1	physical	17505058
KAT2B_HUMAN	KAT2B	physical	17505058

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BCAS3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480 AND SER-488, ANDMASS SPECTROMETRY.	18669648 [Abstract]