NOL11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOL11_HUMAN
• UniProt AC: Q9H8H0
• Protein Name: Nucleolar protein 11
• Gene Name: NOL11
• Organism: Homo sapiens (Human).
• Sequence Length: 719
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b..
• Protein Sequence: MAALEEEFTLSSVVLSAGPEGLLGVEQSDKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLYSIEVLELF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	SAGPEGLLGVEQSDK CCCCCCCCCCCCCCC	12.12	-
42	Phosphorylation	LVTDSGRTVILYKVS EECCCCCEEEEEEEC	18.54	20068231
46	Phosphorylation	SGRTVILYKVSDQKP CCCEEEEEEECCCCC	9.75	20068231
47	Ubiquitination	GRTVILYKVSDQKPL CCEEEEEEECCCCCC	31.64	22817900
49	Phosphorylation	TVILYKVSDQKPLGS EEEEEEECCCCCCCC	30.12	-
52	Acetylation	LYKVSDQKPLGSWSV EEEECCCCCCCCCEE	47.39	26051181
52	Ubiquitination	LYKVSDQKPLGSWSV EEEECCCCCCCCCEE	47.39	21890473
52	Ubiquitination	LYKVSDQKPLGSWSV EEEECCCCCCCCCEE	47.39	21906983
58	Phosphorylation	QKPLGSWSVKQGQII CCCCCCCEEECCEEE	22.57	-
59	Ubiquitination	KPLGSWSVKQGQIIT CCCCCCEEECCEEEE	4.34	23503661
65	Ubiquitination	SVKQGQIITCPAVCN EEECCEEEEECEEEE	2.20	-
65	Ubiquitination	SVKQGQIITCPAVCN EEECCEEEEECEEEE	2.20	22817900
70	Ubiquitination	QIITCPAVCNFQTGE EEEEECEEEECCCCC	1.33	-
70	Ubiquitination	QIITCPAVCNFQTGE EEEEECEEEECCCCC	1.33	22817900
85	Acetylation	YVVVHDNKVLRIWNN EEEEECCEEEEEECC	49.02	26051181
99	Ubiquitination	NEDVNLDKVFKATLS CCCCCHHHHHHHHHH	53.38	21906983
99	Acetylation	NEDVNLDKVFKATLS CCCCCHHHHHHHHHH	53.38	25825284
102	Ubiquitination	VNLDKVFKATLSAEV CCHHHHHHHHHHHHH	43.37	22817900
114	Phosphorylation	AEVYRILSVQGTEPL HHHHHHHHCCCCCCE	15.26	-
125	Ubiquitination	TEPLVLFKEGAVRGL CCCEEEEECCHHHHH	51.59	23000965
125	Ubiquitination	TEPLVLFKEGAVRGL CCCEEEEECCHHHHH	51.59	21890473
125	Acetylation	TEPLVLFKEGAVRGL CCCEEEEECCHHHHH	51.59	25825284
142	Ubiquitination	LLADPQQKIETVISD HHCCHHHHEEEECCH	36.94	29967540
145	Phosphorylation	DPQQKIETVISDEEV CHHHHEEEECCHHHH	26.98	21406692
148	Phosphorylation	QKIETVISDEEVIKW HHEEEECCHHHHHHH	34.33	21406692
162	Ubiquitination	WTKFFVVFRHPVLIF HHEEEEEEECCEEEE	5.09	-
162	Ubiquitination	WTKFFVVFRHPVLIF HHEEEEEEECCEEEE	5.09	29967540
164	Ubiquitination	KFFVVFRHPVLIFIT EEEEEEECCEEEEEE	12.83	-
186	Phosphorylation	AYVQMFNSRILTKYT EEEEECCHHHCHHHH	14.94	-
191	Acetylation	FNSRILTKYTLLLGQ CCHHHCHHHHECCCC	32.56	26051181
205	Ubiquitination	QDENSVIKSFTASVD CCCCHHHHHEEEECC	37.04	-
206	Phosphorylation	DENSVIKSFTASVDR CCCHHHHHEEEECCH	19.39	21406692
208	Phosphorylation	NSVIKSFTASVDRKF CHHHHHEEEECCHHH	25.72	21406692
210	Phosphorylation	VIKSFTASVDRKFIS HHHHEEEECCHHHHH	22.84	21406692
217	Ubiquitination	SVDRKFISLMSLSSD ECCHHHHHHEEECCC	22.58	29967540
225	Ubiquitination	LMSLSSDGCIYETLI HEEECCCCCEEEEEE	11.15	-
229	Ubiquitination	SSDGCIYETLIPIRP CCCCCEEEEEEECCC	19.75	-
237	Ubiquitination	TLIPIRPADPEKNQS EEEECCCCCHHHCHH	34.83	-
237	Ubiquitination	TLIPIRPADPEKNQS EEEECCCCCHHHCHH	34.83	22817900
241	Ubiquitination	IRPADPEKNQSLVKS CCCCCHHHCHHHHHH	66.72	23503661
242	Ubiquitination	RPADPEKNQSLVKSL CCCCHHHCHHHHHHH	34.70	21963094
242	Ubiquitination	RPADPEKNQSLVKSL CCCCHHHCHHHHHHH	34.70	-
247	Ubiquitination	EKNQSLVKSLLLKAV HHCHHHHHHHHHHHH	40.45	21906983
247	Acetylation	EKNQSLVKSLLLKAV HHCHHHHHHHHHHHH	40.45	26051181
252	Ubiquitination	LVKSLLLKAVVSGNA HHHHHHHHHHHCCCC	38.82	22817900
263	Ubiquitination	SGNARNGVALTALDQ CCCCCCCEEEEEECC	4.50	-
283	Phosphorylation	LGSPLAASKECLSVW ECCCCHHCHHHHHHH	24.31	27050516
344	Acetylation	SLAGALGKLKHSQDP HHHHHHHCCCCCCCC	56.03	25953088
344	Ubiquitination	SLAGALGKLKHSQDP HHHHHHHCCCCCCCC	56.03	29967540
346	Ubiquitination	AGALGKLKHSQDPGT HHHHHCCCCCCCCCC	44.70	-
346	Methylation	AGALGKLKHSQDPGT HHHHHCCCCCCCCCC	44.70	24129315
374	Ubiquitination	GCGLGFQNSEQSRRI CCCCCCCCHHHHHHH	45.30	-
374	Ubiquitination	GCGLGFQNSEQSRRI CCCCCCCCHHHHHHH	45.30	21963094
384	Ubiquitination	QSRRILRRRKIEVSL HHHHHHHHCCCEEEE	40.58	33845483
385	Ubiquitination	SRRILRRRKIEVSLQ HHHHHHHCCCEEEEC	37.56	27667366
390	Phosphorylation	RRRKIEVSLQPEVPP HHCCCEEEECCCCCC	14.43	-
391	Ubiquitination	RRKIEVSLQPEVPPS HCCCEEEECCCCCCH	13.71	27667366
399	Ubiquitination	QPEVPPSKQLLSTIM CCCCCCHHHHHHHHH	51.22	29967540
401	Ubiquitination	EVPPSKQLLSTIMKD CCCCHHHHHHHHHHC	4.72	27667366
401	Ubiquitination	EVPPSKQLLSTIMKD CCCCHHHHHHHHHHC	4.72	-
403	Phosphorylation	PPSKQLLSTIMKDSE CCHHHHHHHHHHCCH	25.20	20860994
404	Phosphorylation	PSKQLLSTIMKDSEK CHHHHHHHHHHCCHH	25.67	20860994
407	Ubiquitination	QLLSTIMKDSEKHIE HHHHHHHHCCHHCEE	55.01	-
409	Phosphorylation	LSTIMKDSEKHIEVE HHHHHHCCHHCEEHH	42.92	20860994
411	Acetylation	TIMKDSEKHIEVEVR HHHHCCHHCEEHHHH	54.56	26051181
411	Ubiquitination	TIMKDSEKHIEVEVR HHHHCCHHCEEHHHH	54.56	-
419	Ubiquitination	HIEVEVRKFLALKQT CEEHHHHHHHHHHCC	50.32	22817900
424	Acetylation	VRKFLALKQTPDFHT HHHHHHHHCCCCCCH	46.66	26051181
424	Ubiquitination	VRKFLALKQTPDFHT HHHHHHHHCCCCCCH	46.66	21906983
445	Ubiquitination	TGLLERCKAEPSFYP HHHHHHHCCCCCCCC	63.10	-
494	Ubiquitination	QLCLQQFPDIPESVT HHHHHHCCCCCHHHH	33.99	21890473
494	Ubiquitination	QLCLQQFPDIPESVT HHHHHHCCCCCHHHH	33.99	-
497	Ubiquitination	LQQFPDIPESVTCAC HHHCCCCCHHHHHHH	34.88	22817900
518	Ubiquitination	IGDDSLQETDVNMES CCCCCCCCCCCCHHH	52.87	-
518	Ubiquitination	IGDDSLQETDVNMES CCCCCCCCCCCCHHH	52.87	27667366
556	Ubiquitination	GFNPEEDKCNNCDQE CCCCCCCCCCCCCHH	41.99	21963094
566	Ubiquitination	NCDQELNKKPQDETK CCCHHHHCCCCCCCC	77.71	33845483
567	Ubiquitination	CDQELNKKPQDETKE CCHHHHCCCCCCCCC	47.00	27667366
573	Ubiquitination	KKPQDETKESTSCPV CCCCCCCCCCCCCHH	47.85	27667366
575	Phosphorylation	PQDETKESTSCPVVQ CCCCCCCCCCCHHHH	27.46	20068231
576	Phosphorylation	QDETKESTSCPVVQK CCCCCCCCCCHHHHH	35.13	28270605
577	Phosphorylation	DETKESTSCPVVQKR CCCCCCCCCHHHHHH	26.21	28270605
583	2-Hydroxyisobutyrylation	TSCPVVQKRAALLNA CCCHHHHHHHHHHHH	32.18	-
583	Acetylation	TSCPVVQKRAALLNA CCCHHHHHHHHHHHH	32.18	26051181
583	Ubiquitination	TSCPVVQKRAALLNA CCCHHHHHHHHHHHH	32.18	27667366
597	Phosphorylation	AILHSAYSETFLLPH HHHHHHHCCCCCCHH	29.85	-
599	Phosphorylation	LHSAYSETFLLPHLK HHHHHCCCCCCHHHC	17.40	-
619	Phosphorylation	HITLFLKYLYFLYLK HHHHHHHHHHHHHHH	14.58	21406692
621	Phosphorylation	TLFLKYLYFLYLKCS HHHHHHHHHHHHHCC	6.61	21406692
624	Phosphorylation	LKYLYFLYLKCSENA HHHHHHHHHHCCCCC	8.33	21406692
676	Ubiquitination	RLLINLYKLVKSQIS HHHHHHHHHHHHHHH	50.39	21906983
676	Ubiquitination	RLLINLYKLVKSQIS HHHHHHHHHHHHHHH	50.39	21890473
676	Acetylation	RLLINLYKLVKSQIS HHHHHHHHHHHHHHH	50.39	26051181
679	Ubiquitination	INLYKLVKSQISVYS HHHHHHHHHHHHHHH	47.26	22817900
685	Phosphorylation	VKSQISVYSELNKIE HHHHHHHHHHHHHEE	6.94	27642862
686	Phosphorylation	KSQISVYSELNKIEV HHHHHHHHHHHHEEC	33.19	29978859
694	Phosphorylation	ELNKIEVSFRELQKL HHHHEECHHHHHHHH	13.04	26356563
700	Ubiquitination	VSFRELQKLNQEKNN CHHHHHHHHCHHCCC	63.13	27667366
705	Ubiquitination	LQKLNQEKNNRGLYS HHHHCHHCCCCCCEE	50.16	-
712	Phosphorylation	KNNRGLYSIEVLELF CCCCCCEEEEEEECC	19.81	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOL11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOL11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOL11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UTP15_HUMAN	UTP15	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.