PKHG4_HUMAN - dbPTM
PKHG4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHG4_HUMAN
UniProt AC Q58EX7
Protein Name Puratrophin-1
Gene Name PLEKHG4
Organism Homo sapiens (Human).
Sequence Length 1191
Subcellular Localization
Protein Description Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi..
Protein Sequence MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationPLENGDESPDSQGHA
CCCCCCCCCCCCCCC		38.4525159151
14PhosphorylationNGDESPDSQGHATDW
CCCCCCCCCCCCCCE		41.2528450419
19PhosphorylationPDSQGHATDWRFAVC
CCCCCCCCCEEEEEE		30.3527732954
27PhosphorylationDWRFAVCSFRDAWEE
CEEEEEEECHHHHCC		19.4028165663
56PhosphorylationPRPPAGATQDEELQG
CCCCCCCCCCHHHCC		35.3229978859
64PhosphorylationQDEELQGSPLSRKFQ
CCHHHCCCCCCCCCC		15.0923401153
67PhosphorylationELQGSPLSRKFQLPP
HHCCCCCCCCCCCCC		36.4930266825
69UbiquitinationQGSPLSRKFQLPPAA
CCCCCCCCCCCCCCC		33.80-
139PhosphorylationGPSRAMPSGLSPGAL
CCCCCCCCCCCCCCC		39.0027050516
142PhosphorylationRAMPSGLSPGALDSD
CCCCCCCCCCCCCCC		25.4724667141
148PhosphorylationLSPGALDSDPVGLGD
CCCCCCCCCCCCCCC		44.6727251275
161PhosphorylationGDPLSEISKLLEAAP
CCCHHHHHHHHHHCC		17.1327251275
324 (in isoform 2)Ubiquitination-32.7421906983
342 (in isoform 2)Ubiquitination-49.8821906983
405UbiquitinationGRELTWLKQEVPEVT
CCEEEEEECCCCCCC		35.6521906983
405 (in isoform 1)Ubiquitination-35.6521906983
419PhosphorylationTLSPDYRTAMDKADE
CCCCCHHHHHHHHHH		21.80-
423UbiquitinationDYRTAMDKADELYDR
CHHHHHHHHHHHHHH		44.6521906983
423 (in isoform 1)Ubiquitination-44.6521906983
428PhosphorylationMDKADELYDRVDGLL
HHHHHHHHHHHHHHH		10.3127642862
430 (in isoform 2)Ubiquitination-18.1821906983
511UbiquitinationEQVRQGEKFLQPLTG
HHHHCCCCCCCCCCC		59.1921906983
511 (in isoform 1)Ubiquitination-59.1921906983
608UbiquitinationLPPAHFRKMWALATG
CCHHHHHHHHHHHHC		37.54-
642UbiquitinationTWLALDQKLEASLKL
HHHHHHHHHHHHHCC		48.22-
648UbiquitinationQKLEASLKLPPVGST
HHHHHHHCCCCCCCH		57.35-
674UbiquitinationPAHPPLRKAYSFDRN
CCCCCCHHHHCCCCC		60.40-
676PhosphorylationHPPLRKAYSFDRNLG
CCCCHHHHCCCCCCC		16.9528634120
677PhosphorylationPPLRKAYSFDRNLGQ
CCCHHHHCCCCCCCC		26.0722167270
685PhosphorylationFDRNLGQSLSEPACH
CCCCCCCCCCCCCCC		31.8728464451
687PhosphorylationRNLGQSLSEPACHCH
CCCCCCCCCCCCCCC		46.9428464451
698PhosphorylationCHCHHAATIAACRRP
CCCCHHHHHHHHCCC		16.3623312004
716PhosphorylationGGALPQASPTVPPPG
CCCCCCCCCCCCCCC		18.8228985074
718PhosphorylationALPQASPTVPPPGSS
CCCCCCCCCCCCCCC		43.0529214152
724PhosphorylationPTVPPPGSSDPRSLN
CCCCCCCCCCHHHHH		37.0223312004
725PhosphorylationTVPPPGSSDPRSLNR
CCCCCCCCCHHHHHH		58.5123312004
784UbiquitinationHLFGNLEKLRDFHCH
HHHCCHHHHHHHHHH		52.57-
844UbiquitinationSYGHTFFKDKQQALG
HHCCCHHHCHHHHHH		60.88-
846UbiquitinationGHTFFKDKQQALGDH
CCCHHHCHHHHHHHH		44.92-
858PhosphorylationGDHLDLASYLLKPIQ
HHHHHHHHHHHHHHH		24.5024719451
859PhosphorylationDHLDLASYLLKPIQR
HHHHHHHHHHHHHHH		15.5024719451
862UbiquitinationDLASYLLKPIQRMGK
HHHHHHHHHHHHCHH		37.16-
869UbiquitinationKPIQRMGKYALLLQE
HHHHHCHHHHHHHHH		20.29-
890 (in isoform 2)Ubiquitination-24.2221906983
922UbiquitinationQGCDVNLKEQGQLVR
CCCCCCHHHHCCEEE		42.67-
956PhosphorylationFEELLLFSKPRHGPT
HHHHHHHCCCCCCCC		41.5424719451
968 (in isoform 2)Ubiquitination-6.3921906983
970PhosphorylationTGVDTFAYKRSFKMA
CCCHHHHHHCCCCCC		11.62-
971UbiquitinationGVDTFAYKRSFKMAD
CCHHHHHHCCCCCCC		37.8321906983
971 (in isoform 1)Ubiquitination-37.8321906983
975UbiquitinationFAYKRSFKMADLGLT
HHHHCCCCCCCCCCC		34.13-
1049 (in isoform 1)Ubiquitination-42.8621906983
1049UbiquitinationVSMGVGNKAFRDIAP
HHCCCCCHHHHHCCC		42.862190698
1057PhosphorylationAFRDIAPSEEAINDR
HHHHCCCCHHHHCCC		38.7620068231
1064MethylationSEEAINDRTVNYVLK
CHHHHCCCCHHHHEE		35.76115487869
1065PhosphorylationEEAINDRTVNYVLKC
HHHHCCCCHHHHEEC		18.9020068231
1068PhosphorylationINDRTVNYVLKCREV
HCCCCHHHHEECHHH		11.6520068231
1071UbiquitinationRTVNYVLKCREVRSR
CCHHHHEECHHHHCC		22.62-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHG4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHG4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHG4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PKHG4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHG4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.

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