dbPTM

TGON2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TGON2_HUMAN
UniProt AC	O43493
Protein Name	Trans-Golgi network integral membrane protein 2
Gene Name	TGOLN2
Organism	Homo sapiens (Human).
Sequence Length	479
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane Single-pass type I membrane protein. Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endoso
Protein Description	May be involved in regulating membrane traffic to and from trans-Golgi network..
Protein Sequence	MRFVVALVLLNVAAAGAVPLLATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAESSHFFAYLVTAAILVAVLYIAHHNKRKIIAFVLEGKRSKVTRRPKASDYQRLDQKYVLILNVFPAPPKRSFFPVLTEWYIPLEKDERHQWIVLLSFQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	O-linked_Glycosylation	GAVPLLATESVKQEE CCCCCCCCCCHHHHH	28.85	OGP
36	O-linked_Glycosylation	EEAGVRPSAGNVSTH HHCCCCCCCCCCCCC	37.94	55833463
39	N-linked_Glycosylation	GVRPSAGNVSTHPSL CCCCCCCCCCCCCCH	25.04	UniProtKB CARBOHYD
41	O-linked_Glycosylation	RPSAGNVSTHPSLSQ CCCCCCCCCCCCHHC	25.62	55833467
42	O-linked_Glycosylation	PSAGNVSTHPSLSQR CCCCCCCCCCCHHCC	33.26	55833471
45	O-linked_Glycosylation	GNVSTHPSLSQRPGG CCCCCCCCHHCCCCC	32.80	55833475
47	O-linked_Glycosylation	VSTHPSLSQRPGGST CCCCCCHHCCCCCCC	28.60	55833479
53	O-linked_Glycosylation	LSQRPGGSTKSHPEP HHCCCCCCCCCCCCC	38.28	55833483
54	O-linked_Glycosylation	SQRPGGSTKSHPEPQ HCCCCCCCCCCCCCC	39.58	55833487
56	O-linked_Glycosylation	RPGGSTKSHPEPQTP CCCCCCCCCCCCCCC	44.34	55824035
62	O-linked_Glycosylation	KSHPEPQTPKDSPSK CCCCCCCCCCCCCCC	42.92	55824039
62	Phosphorylation	KSHPEPQTPKDSPSK CCCCCCCCCCCCCCC	42.92	26091039
66	Phosphorylation	EPQTPKDSPSKSSAE CCCCCCCCCCCCCCC	36.88	29255136
68	O-linked_Glycosylation	QTPKDSPSKSSAEAQ CCCCCCCCCCCCCCC	49.47	OGP
68	Phosphorylation	QTPKDSPSKSSAEAQ CCCCCCCCCCCCCCC	49.47	29255136
70	O-linked_Glycosylation	PKDSPSKSSAEAQTP CCCCCCCCCCCCCCC	38.83	OGP
70	Phosphorylation	PKDSPSKSSAEAQTP CCCCCCCCCCCCCCC	38.83	29255136
71	O-linked_Glycosylation	KDSPSKSSAEAQTPE CCCCCCCCCCCCCCC	33.59	OGP
71	Phosphorylation	KDSPSKSSAEAQTPE CCCCCCCCCCCCCCC	33.59	29255136
76	O-linked_Glycosylation	KSSAEAQTPEDTPNK CCCCCCCCCCCCCCC	35.38	OGP
76	Phosphorylation	KSSAEAQTPEDTPNK CCCCCCCCCCCCCCC	35.38	29255136
80	Phosphorylation	EAQTPEDTPNKSGAE CCCCCCCCCCCCHHH	27.40	23927012
82	N-linked_Glycosylation	QTPEDTPNKSGAEAK CCCCCCCCCCHHHHH	53.90	UniProtKB CARBOHYD
84	Phosphorylation	PEDTPNKSGAEAKTQ CCCCCCCCHHHHHHC	50.29	22798277
94	Phosphorylation	EAKTQKDSSNKSGAE HHHHCCCCCCCCCHH	42.73	17287340
95	Phosphorylation	AKTQKDSSNKSGAEA HHHCCCCCCCCCHHH	59.41	21601212
96	N-linked_Glycosylation	KTQKDSSNKSGAEAK HHCCCCCCCCCHHHH	46.60	UniProtKB CARBOHYD
98	Phosphorylation	QKDSSNKSGAEAKTQ CCCCCCCCCHHHHHC	47.70	17287340
114	Phosphorylation	GSTSKSGSEAQTTKD CCCCCCCCCCCCCCC	36.53	-
118	O-linked_Glycosylation	KSGSEAQTTKDSTSK CCCCCCCCCCCCCCC	42.75	55829725
118	Phosphorylation	KSGSEAQTTKDSTSK CCCCCCCCCCCCCCC	42.75	-
119	O-linked_Glycosylation	SGSEAQTTKDSTSKS CCCCCCCCCCCCCCC	22.30	55829731
119	Phosphorylation	SGSEAQTTKDSTSKS CCCCCCCCCCCCCCC	22.30	-
122	O-linked_Glycosylation	EAQTTKDSTSKSHPE CCCCCCCCCCCCCCC	35.82	55829737
123	O-linked_Glycosylation	AQTTKDSTSKSHPEL CCCCCCCCCCCCCCC	50.75	55829741
123	Phosphorylation	AQTTKDSTSKSHPEL CCCCCCCCCCCCCCC	50.75	24275569
124	O-linked_Glycosylation	QTTKDSTSKSHPELQ CCCCCCCCCCCCCCC	35.79	55829745
126	O-linked_Glycosylation	TKDSTSKSHPELQTP CCCCCCCCCCCCCCC	44.00	55823947
126	Phosphorylation	TKDSTSKSHPELQTP CCCCCCCCCCCCCCC	44.00	-
132	O-linked_Glycosylation	KSHPELQTPKDSTGK CCCCCCCCCCCCCCC	44.95	36033481
132	Phosphorylation	KSHPELQTPKDSTGK CCCCCCCCCCCCCCC	44.95	20068231
136	O-linked_Glycosylation	ELQTPKDSTGKSGAE CCCCCCCCCCCCCCC	45.23	55833185
136	Phosphorylation	ELQTPKDSTGKSGAE CCCCCCCCCCCCCCC	45.23	-
137	O-linked_Glycosylation	LQTPKDSTGKSGAEA CCCCCCCCCCCCCCC	59.78	55833189
137	Phosphorylation	LQTPKDSTGKSGAEA CCCCCCCCCCCCCCC	59.78	-
140	Phosphorylation	PKDSTGKSGAEAQTP CCCCCCCCCCCCCCC	44.58	22798277
146	O-linked_Glycosylation	KSGAEAQTPEDSPNR CCCCCCCCCCCCCCC	35.38	OGP
146	Phosphorylation	KSGAEAQTPEDSPNR CCCCCCCCCCCCCCC	35.38	26699800
147 (in isoform 6)	Phosphorylation	-	31.17	24275569
150	Phosphorylation	EAQTPEDSPNRSGAE CCCCCCCCCCCCHHH	23.55	21815630
150 (in isoform 6)	Phosphorylation	-	23.55	26699800
152	N-linked_Glycosylation	QTPEDSPNRSGAEAK CCCCCCCCCCHHHCC	55.49	UniProtKB CARBOHYD
154	Phosphorylation	PEDSPNRSGAEAKTQ CCCCCCCCHHHCCCC	49.33	28192239
158 (in isoform 6)	Phosphorylation	-	21.47	25849741
159 (in isoform 6)	Phosphorylation	-	42.89	26699800
160	Phosphorylation	RSGAEAKTQKDSPSK CCHHHCCCCCCCCCC	48.15	23312004
162 (in isoform 6)	Phosphorylation	-	66.46	26699800
164	Phosphorylation	EAKTQKDSPSKSGSE HCCCCCCCCCCCCCC	37.80	23312004
166	Phosphorylation	KTQKDSPSKSGSEAQ CCCCCCCCCCCCCCC	43.32	23312004
168	Phosphorylation	QKDSPSKSGSEAQTT CCCCCCCCCCCCCCC	52.46	23312004
170	Phosphorylation	DSPSKSGSEAQTTKD CCCCCCCCCCCCCCC	36.53	24505115
174	O-linked_Glycosylation	KSGSEAQTTKDVPNK CCCCCCCCCCCCCCC	42.75	OGP
175	O-linked_Glycosylation	SGSEAQTTKDVPNKS CCCCCCCCCCCCCCC	17.11	OGP
180	N-linked_Glycosylation	QTTKDVPNKSGADGQ CCCCCCCCCCCCCCC	51.48	UniProtKB CARBOHYD
182	O-linked_Glycosylation	TKDVPNKSGADGQTP CCCCCCCCCCCCCCC	45.94	OGP
188	O-linked_Glycosylation	KSGADGQTPKDGSSK CCCCCCCCCCCCCCC	37.52	OGP
194	O-linked_Glycosylation	QTPKDGSSKSGAEDQ CCCCCCCCCCCCCCC	36.05	OGP
196	Phosphorylation	PKDGSSKSGAEDQTP CCCCCCCCCCCCCCC	45.22	28102081
202	O-linked_Glycosylation	KSGAEDQTPKDVPNK CCCCCCCCCCCCCCC	44.63	55829345
202	Phosphorylation	KSGAEDQTPKDVPNK CCCCCCCCCCCCCCC	44.63	28102081
208	N-linked_Glycosylation	QTPKDVPNKSGAEKQ CCCCCCCCCCCCCCC	51.48	UniProtKB CARBOHYD
210	Phosphorylation	PKDVPNKSGAEKQTP CCCCCCCCCCCCCCC	50.29	28857561
221	Phosphorylation	KQTPKDGSNKSGAEE CCCCCCCCCCCCCHH	51.74	29255136
222	N-linked_Glycosylation	QTPKDGSNKSGAEEQ CCCCCCCCCCCCHHC	48.30	UniProtKB CARBOHYD
224	O-linked_Glycosylation	PKDGSNKSGAEEQGP CCCCCCCCCCHHCCC	47.70	OGP
224	Phosphorylation	PKDGSNKSGAEEQGP CCCCCCCCCCHHCCC	47.70	29255136
236	O-linked_Glycosylation	QGPIDGPSKSGAEEQ CCCCCCCCCCCCCCC	45.01	55832785
236	Phosphorylation	QGPIDGPSKSGAEEQ CCCCCCCCCCCCCCC	45.01	28355574
238	O-linked_Glycosylation	PIDGPSKSGAEEQTS CCCCCCCCCCCCCCC	47.80	OGP
238	Phosphorylation	PIDGPSKSGAEEQTS CCCCCCCCCCCCCCC	47.80	22798277
244	Phosphorylation	KSGAEEQTSKDSPNK CCCCCCCCCCCCCCC	40.81	24719451
245	O-linked_Glycosylation	SGAEEQTSKDSPNKV CCCCCCCCCCCCCCC	33.87	68999563
245	Phosphorylation	SGAEEQTSKDSPNKV CCCCCCCCCCCCCCC	33.87	22798277
245 (in isoform 4)	Phosphorylation	-	33.87	24275569
248 (in isoform 4)	Phosphorylation	-	33.82	26699800
256 (in isoform 4)	Phosphorylation	-	34.89	25849741
257 (in isoform 4)	Phosphorylation	-	34.14	26699800
260 (in isoform 4)	Phosphorylation	-	65.22	26699800
263	O-linked_Glycosylation	QPSRKDHSKPISNPS CCCCCCCCCCCCCCC	50.70	68999757
263	Phosphorylation	QPSRKDHSKPISNPS CCCCCCCCCCCCCCC	50.70	24275569
267	O-linked_Glycosylation	KDHSKPISNPSDNKE CCCCCCCCCCCCCCC	51.74	55832319
267	Phosphorylation	KDHSKPISNPSDNKE CCCCCCCCCCCCCCC	51.74	-
270	O-linked_Glycosylation	SKPISNPSDNKELPK CCCCCCCCCCCCCCC	59.05	55832325
270	Phosphorylation	SKPISNPSDNKELPK CCCCCCCCCCCCCCC	59.05	-
272 (in isoform 6)	Phosphorylation	-	44.00	28152594
274 (in isoform 6)	Phosphorylation	-	76.26	28152594
290	O-linked_Glycosylation	LADKGKLSPHAFKTE HHHHCCCCCCCEECC	20.37	101661085
290	Phosphorylation	LADKGKLSPHAFKTE HHHHCCCCCCCEECC	20.37	23927012
296	O-linked_Glycosylation	LSPHAFKTESGEETD CCCCCEECCCCCCCC	29.00	OGP
296	Phosphorylation	LSPHAFKTESGEETD CCCCCEECCCCCCCC	29.00	29255136
298	Phosphorylation	PHAFKTESGEETDLI CCCEECCCCCCCCCC	57.65	29255136
302	Phosphorylation	KTESGEETDLISPPQ ECCCCCCCCCCCCCH	31.63	23927012
306	Phosphorylation	GEETDLISPPQEEVK CCCCCCCCCCHHHHC	37.51	23927012
314	Phosphorylation	PPQEEVKSSEPTEDV CCHHHHCCCCCCCCC	45.14	25849741
315	O-linked_Glycosylation	PQEEVKSSEPTEDVE CHHHHCCCCCCCCCC	41.71	OGP
315	Phosphorylation	PQEEVKSSEPTEDVE CHHHHCCCCCCCCCC	41.71	25849741
318	O-linked_Glycosylation	EVKSSEPTEDVEPKE HHCCCCCCCCCCCCC	40.54	55832013
318	Phosphorylation	EVKSSEPTEDVEPKE HHCCCCCCCCCCCCC	40.54	29507054
331	Phosphorylation	KEAEDDDTGPEEGSP CCCCCCCCCCCCCCC	62.72	-
347	Phosphorylation	KEEKEKMSGSASSEN HHHHHHHCCCCCCCC	40.44	22617229
349	Phosphorylation	EKEKMSGSASSENRE HHHHHCCCCCCCCCC	20.05	25159151
351	Phosphorylation	EKMSGSASSENREGT HHHCCCCCCCCCCCC	39.62	28355574
352	Phosphorylation	KMSGSASSENREGTL HHCCCCCCCCCCCCC	38.31	30278072
358	Phosphorylation	SSENREGTLSDSTGS CCCCCCCCCCCCCCC	20.52	20639409
359	Ubiquitination	SENREGTLSDSTGSE CCCCCCCCCCCCCCC	8.66	33845483
360	Phosphorylation	ENREGTLSDSTGSEK CCCCCCCCCCCCCCC	29.38	30576142
362	Phosphorylation	REGTLSDSTGSEKDD CCCCCCCCCCCCCCC	31.15	20639409
363	Phosphorylation	EGTLSDSTGSEKDDL CCCCCCCCCCCCCCC	50.12	20639409
365	Phosphorylation	TLSDSTGSEKDDLYP CCCCCCCCCCCCCCC	41.37	20639409
368	Ubiquitination	DSTGSEKDDLYPNGS CCCCCCCCCCCCCCC	47.28	29967540
370 (in isoform 4)	Phosphorylation	-	12.58	28152594
372 (in isoform 4)	Phosphorylation	-	46.10	28152594
373	N-linked_Glycosylation	EKDDLYPNGSGNGSA CCCCCCCCCCCCCCH	43.64	UniProtKB CARBOHYD
377	N-linked_Glycosylation	LYPNGSGNGSAESSH CCCCCCCCCCHHHHH	42.83	UniProtKB CARBOHYD
417	Ubiquitination	IAFVLEGKRSKVTRR EEEEECCCCCCCCCC	44.09	33845483
419	Phosphorylation	FVLEGKRSKVTRRPK EEECCCCCCCCCCCC	34.66	29514088
426	Ubiquitination	SKVTRRPKASDYQRL CCCCCCCCHHHHHHC	59.73	29967540
428	Phosphorylation	VTRRPKASDYQRLDQ CCCCCCHHHHHHCCC	42.87	28152594
428 (in isoform 2)	Phosphorylation	-	42.87	28152594
430	Phosphorylation	RRPKASDYQRLDQKY CCCCHHHHHHCCCEE	7.95	28152594
430 (in isoform 2)	Phosphorylation	-	7.95	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
221	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
298	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
302	T	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
351	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TGON2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TGON2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB1_HUMAN	ITGB1	physical	11208159
AP1M1_HUMAN	AP1M1	physical	10814565
AP2M1_HUMAN	AP2M1	physical	10814565
AP3M1_HUMAN	AP3M1	physical	10814565
KR109_HUMAN	KRTAP10-9	physical	25416956
MDN1_HUMAN	MDN1	physical	26186194
DPOE1_HUMAN	POLE	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
NU188_HUMAN	NUP188	physical	26186194
HEAT1_HUMAN	HEATR1	physical	26186194
GPD1L_HUMAN	GPD1L	physical	26186194
INT12_HUMAN	INTS12	physical	26186194
SYLM_HUMAN	LARS2	physical	26186194
IPO13_HUMAN	IPO13	physical	26186194
INT4_HUMAN	INTS4	physical	26186194
RUS1_HUMAN	C16orf58	physical	26186194
GOPC_HUMAN	GOPC	physical	26186194
NUP85_HUMAN	NUP85	physical	26186194
LTN1_HUMAN	LTN1	physical	26186194
PDS5B_HUMAN	PDS5B	physical	26186194
CHD1L_HUMAN	CHD1L	physical	26186194
XPR1_HUMAN	XPR1	physical	26186194
GALT2_HUMAN	GALNT2	physical	26186194
AP1M1_HUMAN	AP1M1	physical	26186194
INT1_HUMAN	INTS1	physical	26186194
HS2ST_HUMAN	HS2ST1	physical	26186194
INT2_HUMAN	INTS2	physical	26186194
ITIH3_HUMAN	ITIH3	physical	26186194
ALG2_HUMAN	ALG2	physical	26186194
GNL3L_HUMAN	GNL3L	physical	26186194
ARF6_HUMAN	ARF6	physical	26186194
HS12A_HUMAN	HSPA12A	physical	26186194
RHBD3_HUMAN	RHBDD3	physical	26186194
ARF5_HUMAN	ARF5	physical	26186194
UGDH_HUMAN	UGDH	physical	26186194
INT5_HUMAN	INTS5	physical	26186194
RAB18_HUMAN	RAB18	physical	26186194
NF1_HUMAN	NF1	physical	26186194
LCHN_HUMAN	KIAA1147	physical	26186194
RAB14_HUMAN	RAB14	physical	26186194
RRAGB_HUMAN	RRAGB	physical	26186194
RUFY1_HUMAN	RUFY1	physical	26186194
RAB3A_HUMAN	RAB3A	physical	26186194
RAB3B_HUMAN	RAB3B	physical	26186194
RAB13_HUMAN	RAB13	physical	26186194
RA51C_HUMAN	RAD51C	physical	26186194
TBL3_HUMAN	TBL3	physical	26186194
ALG2_HUMAN	ALG2	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
GOPC_HUMAN	GOPC	physical	28514442
INT4_HUMAN	INTS4	physical	28514442
IPO13_HUMAN	IPO13	physical	28514442
GPD1L_HUMAN	GPD1L	physical	28514442
RRAGB_HUMAN	RRAGB	physical	28514442
RUFY1_HUMAN	RUFY1	physical	28514442
INT1_HUMAN	INTS1	physical	28514442
RHBD3_HUMAN	RHBDD3	physical	28514442
LTN1_HUMAN	LTN1	physical	28514442
GALT2_HUMAN	GALNT2	physical	28514442
RAB3B_HUMAN	RAB3B	physical	28514442
RAB3A_HUMAN	RAB3A	physical	28514442
INT5_HUMAN	INTS5	physical	28514442
AP1M1_HUMAN	AP1M1	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442
XPR1_HUMAN	XPR1	physical	28514442
MDN1_HUMAN	MDN1	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
SYLM_HUMAN	LARS2	physical	28514442
LCHN_HUMAN	KIAA1147	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TGON2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-98, AND MASSSPECTROMETRY.	17287340 [Abstract]