HS2ST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS2ST_HUMAN
• UniProt AC: Q7LGA3
• Protein Name: Heparan sulfate 2-O-sulfotransferase 1
• Gene Name: HS2ST1
• Organism: Homo sapiens (Human).
• Sequence Length: 356
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity)..
• Protein Sequence: MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMDGPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	O-linked_Glycosylation	REIEQRHTMDGPRQD HHHHHHHCCCCCCCC	21.10	OGP
78	Phosphorylation	EEDMVIIYNRVPKTA CCCEEEEECCCCCCC	5.93	22817900
101	Ubiquitination	YDLCAKNKYHVLHIN HHHHHCCCEEEEEEE	35.71	-
102	Phosphorylation	DLCAKNKYHVLHINT HHHHCCCEEEEEEEC	13.42	22210691
108	N-linked_Glycosylation	KYHVLHINTTKNNPV CEEEEEEECCCCCCC	30.83	UniProtKB CARBOHYD
109	Phosphorylation	YHVLHINTTKNNPVM EEEEEEECCCCCCCC	38.25	22210691
110	Phosphorylation	HVLHINTTKNNPVMS EEEEEECCCCCCCCC	27.56	22210691
123	Methylation	MSLQDQVRFVKNITS CCHHHHHHHHHHHCC	25.63	24410261
123	Dimethylation	MSLQDQVRFVKNITS CCHHHHHHHHHHHCC	25.63	-
126	Ubiquitination	QDQVRFVKNITSWKE HHHHHHHHHHCCHHH	39.66	-
127	N-linked_Glycosylation	DQVRFVKNITSWKEM HHHHHHHHHCCHHHC	37.15	UniProtKB CARBOHYD
164	Methylation	PIYINVIRDPIERLV CEEEEEECCHHHHHH	39.09	115479677
183	Phosphorylation	FLRFGDDYRPGLRRR HHHCCCCCCCCCCCC	24.36	-
298	Ubiquitination	TEKKLPTKQTIAKLQ CCCCCCCHHHHHHHH	43.43	29967540
303	Ubiquitination	PTKQTIAKLQQSDIW CCHHHHHHHHHHHHH	42.87	29967540
340	Phosphorylation	REKDGDLYILAQNFF ECCCCCEEEEEECCH	9.91	22817900
348	Phosphorylation	ILAQNFFYEKIYPKS EEEECCHHHHHCCCC	16.51	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS2ST_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS2ST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS2ST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT12A_HUMAN	ATP12A	physical	26186194
NMNA3_HUMAN	NMNAT3	physical	26186194
DIAP3_HUMAN	DIAPH3	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
1A02_HUMAN	HLA-A	physical	26186194
1A03_HUMAN	HLA-A	physical	26186194
1A01_HUMAN	HLA-A	physical	26186194
1A26_HUMAN	HLA-A	physical	26186194
TBC23_HUMAN	TBC1D23	physical	26186194
DYM_HUMAN	DYM	physical	26186194
PIGU_HUMAN	PIGU	physical	26186194
NMNA3_HUMAN	NMNAT3	physical	28514442
SOGA3_HUMAN	SOGA3	physical	28514442
TBC23_HUMAN	TBC1D23	physical	28514442
DIAP3_HUMAN	DIAPH3	physical	28514442
USP9Y_HUMAN	USP9Y	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
DYM_HUMAN	DYM	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
CTR1_HUMAN	SLC7A1	physical	28514442
A4_HUMAN	APP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.