NMNA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMNA3_HUMAN
• UniProt AC: Q96T66
• Protein Name: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 {ECO:0000305}
• Gene Name: NMNAT3
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury..
• Protein Sequence: MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKALFSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYTKGSTWKGKSTQSTEGKTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	HLHQTGMYQVIQGII HHHHHCHHHHHHHHC	10.85	27732954
47	Phosphorylation	QVIQGIISPVNDTYG HHHHHHCCCCCCCCC	22.37	27732954
52	Phosphorylation	IISPVNDTYGKKDLA HCCCCCCCCCCHHHH	29.04	-
95	Acetylation	AQWMETVKVLRHHHS HHHHHHHHHHHHHHH	42.86	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMNA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMNA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMNA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPTB1_HUMAN	SPTB	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.