dbPTM

CTR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CTR1_HUMAN
UniProt AC	P30825
Protein Name	High affinity cationic amino acid transporter 1
Gene Name	SLC7A1 {ECO:0000312\|HGNC:HGNC:11057}
Organism	Homo sapiens (Human).
Sequence Length	629
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues..
Protein Sequence	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQARTPDGNLDQCK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
3	S-palmitoylation	-----MGCKVLLNIG -----CCCCEECCHH	2.38	29575903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CTR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CTR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CTR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FATE1_HUMAN	FATE1	physical	25416956
RAC3_HUMAN	RAC3	physical	28514442
B2L13_HUMAN	BCL2L13	physical	28514442
MET7A_HUMAN	METTL7A	physical	28514442
MTCH2_HUMAN	MTCH2	physical	28514442
DGAT1_HUMAN	DGAT1	physical	28514442
ZDH21_HUMAN	ZDHHC21	physical	28514442
T120B_HUMAN	TMEM120B	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
STX4_HUMAN	STX4	physical	28514442
LEMD2_HUMAN	LEMD2	physical	28514442
PLCC_HUMAN	AGPAT3	physical	28514442
S35B2_HUMAN	SLC35B2	physical	28514442
TV23C_HUMAN	TVP23C	physical	28514442
MGT5A_HUMAN	MGAT5	physical	28514442
PLCD_HUMAN	AGPAT4	physical	28514442
FKRP_HUMAN	FKRP	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
YIPF4_HUMAN	YIPF4	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
ELOV5_HUMAN	ELOVL5	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
MAVS_HUMAN	MAVS	physical	28514442
TM268_HUMAN	C9orf91	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
NB5R1_HUMAN	CYB5R1	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
PIGW_HUMAN	PIGW	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
CKLF4_HUMAN	CMTM4	physical	28514442
YIPF6_HUMAN	YIPF6	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
GOLM1_HUMAN	GOLM1	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
TIM29_HUMAN	C19orf52	physical	28514442
ELOV4_HUMAN	ELOVL4	physical	28514442
NAT14_HUMAN	NAT14	physical	28514442
PARL_HUMAN	PARL	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00125	L-Arginine
DB00123	L-Lysine
DB00129	L-Ornithine

Regulatory Network of CTR1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-226, AND MASSSPECTROMETRY.	19349973 [Abstract]