dbPTM

TM268_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TM268_HUMAN
UniProt AC	Q5VZI3
Protein Name	Transmembrane protein 268 {ECO:0000312\|HGNC:HGNC:24513}
Gene Name	TMEM268 {ECO:0000312\|HGNC:HGNC:24513}
Organism	Homo sapiens (Human).
Sequence Length	342
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MACEPQVDPGATGPLPPSSPGWSALPGGSPPGWGQELHNGQVLTVLRIDNTCAPISFDLGAAEEQLQTWGIQVPADQYRSLAESALLEPQVRRYIIYNSRPMRLAFAVVFYVVVWANIYSTSQMFALGNHWAGMLLVTLAAVSLTLTLVLVFERHQKKANTNTDLRLAAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEMKTSQESLLRSRLSQLCVVMETGVSPATAEGPENLEDAPLLPGNSCPNERPLMQTELHQLVPEAEPEEMARQLLAVFGGYYIRLLVTSQLPQAMGTRHTNSPRIPCPCQLIEAYILGTGCCPFLAR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
4 (in isoform 2)	Phosphorylation	-	24043423
10 (in isoform 2)	Phosphorylation	-	24043423
18	Phosphorylation	ATGPLPPSSPGWSAL CCCCCCCCCCCCCCC	27251275
19	Phosphorylation	TGPLPPSSPGWSALP CCCCCCCCCCCCCCC	27251275
23 (in isoform 2)	Phosphorylation	-	24043423
94	Phosphorylation	LEPQVRRYIIYNSRP CCHHHHHHHEECCCC	27174698
97	Phosphorylation	QVRRYIIYNSRPMRL HHHHHHEECCCCHHH	27174698
99	Phosphorylation	RRYIIYNSRPMRLAF HHHHEECCCCHHHHH	27174698
158	Methylation	VFERHQKKANTNTDL HHHHHHHHCCCCHHH	23644510
158	Trimethylation	VFERHQKKANTNTDL HHHHHHHHCCCCHHH	-
296	Phosphorylation	LLAVFGGYYIRLLVT HHHHHCHHHHHHHHH	24043423
297	Phosphorylation	LAVFGGYYIRLLVTS HHHHCHHHHHHHHHC	24043423
303	Phosphorylation	YYIRLLVTSQLPQAM HHHHHHHHCCCCHHH	25072903
304	Phosphorylation	YIRLLVTSQLPQAMG HHHHHHHCCCCHHHC	25072903
312	Phosphorylation	QLPQAMGTRHTNSPR CCCHHHCCCCCCCCC	25072903
315	Phosphorylation	QAMGTRHTNSPRIPC HHHCCCCCCCCCCCC	25072903
317	Phosphorylation	MGTRHTNSPRIPCPC HCCCCCCCCCCCCCH	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TM268_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TM268_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TM268_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
REL_HUMAN	REL	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TM268_HUMAN

Related Literatures of Post-Translational Modification