ITIH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITIH3_HUMAN
• UniProt AC: Q06033
• Protein Name: Inter-alpha-trypsin inhibitor heavy chain H3
• Gene Name: ITIH3
• Organism: Homo sapiens (Human).
• Sequence Length: 890
• Subcellular Localization: Secreted.
• Protein Description: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes..
• Protein Sequence: MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	VYSTKINSKVTSRFA EEEEECCCHHHHHHC	31.79	26270265
91	N-linked_Glycosylation	PKTAFITNFTLTIDG CCEEEECEEEEEECC	24.08	16335952
124	Phosphorylation	KAVSQGKTAGLVKAS HHHHCCCCEEEEECC	32.55	-
167	Phosphorylation	LKRHKGKYEMYLKVQ HHHCCCEEEEEEEEC	18.01	-
170	Phosphorylation	HKGKYEMYLKVQPKQ CCCEEEEEEEECHHH	7.45	-
195	Phosphorylation	IFEPQGISMLDAEAS EECCCCCCCHHHHHH	21.81	20068231
205	Phosphorylation	DAEASFITNDLLGSA HHHHHHHHHHHHHHH	22.22	20068231
211	Phosphorylation	ITNDLLGSALTKSFS HHHHHHHHHHCHHCC	21.78	20068231
214	Phosphorylation	DLLGSALTKSFSGKK HHHHHHHCHHCCCCC	25.10	20068231
292	Phosphorylation	VAFVIDISGSMAGRK EEEEEECCCCCCCCC	22.52	-
294	Phosphorylation	FVIDISGSMAGRKLE EEEECCCCCCCCCHH	9.92	-
340	O-linked_Glycosylation	KEHLVQATPENLQEA HHHHHHCCHHHHHHH	17.65	OGP
340	Phosphorylation	KEHLVQATPENLQEA HHHHHHCCHHHHHHH	17.65	24505115
353	Phosphorylation	EARTFVKSMEDKGMT HHHHHHHHHHHCCCC	23.31	29083192
360	Phosphorylation	SMEDKGMTNINDGLL HHHHCCCCCCCHHHH	41.43	20860994
386	Phosphorylation	EHRIPERSTSIVIML HCCCCCCCCEEEEEE	25.50	-
387	Phosphorylation	HRIPERSTSIVIMLT CCCCCCCCEEEEEEE	28.79	-
388	Phosphorylation	RIPERSTSIVIMLTD CCCCCCCEEEEEEEC	18.99	-
571	Acetylation	EQLLEKRKNAHGEEK HHHHHHHHHCCCCHH	70.34	20167786
580	N-linked_Glycosylation	AHGEEKENLTARALD CCCCHHHHHHHHHHH	54.48	17623646
580	N-linked_Glycosylation	AHGEEKENLTARALD CCCCHHHHHHHHHHH	54.48	16335952
589	Phosphorylation	TARALDLSLKYHFVT HHHHHHHHHEEEEEC	23.60	20860994
592	Phosphorylation	ALDLSLKYHFVTPLT HHHHHHEEEEECCCC	13.04	-
651	Other	PYYYVDGDPHFIIQI CCEEECCCCCEEEEC	29.10	-
651	Aspartate 1-(chondroitin 4-sulfate)-ester	PYYYVDGDPHFIIQI CCEEECCCCCEEEEC	29.10	-
700	Phosphorylation	ITGDKRGSPDSKTRK ECCCCCCCCCCCCCC	29.57	-
703	Phosphorylation	DKRGSPDSKTRKTYF CCCCCCCCCCCCEEE	39.03	-
705	Phosphorylation	RGSPDSKTRKTYFGK CCCCCCCCCCEEEHH	41.15	20068231
708	Phosphorylation	PDSKTRKTYFGKLGI CCCCCCCEEEHHHCC	22.31	20068231
709	Phosphorylation	DSKTRKTYFGKLGIA CCCCCCEEEHHHCCC	17.23	20068231
727	Phosphorylation	MDFQVEVTTEKITLW EEEEEEEECCEEEEC	18.74	20068231
728	Phosphorylation	DFQVEVTTEKITLWN EEEEEEECCEEEECC	40.22	20068231
822	Phosphorylation	QPFDFKVSDIRPGSD CCCCEEHHHCCCCCC	28.10	30576142
828	Phosphorylation	VSDIRPGSDPTKPDA HHHCCCCCCCCCCCC	43.00	30576142
831	Phosphorylation	IRPGSDPTKPDATLV CCCCCCCCCCCCEEE	61.27	30576142
831	O-linked_Glycosylation	IRPGSDPTKPDATLV CCCCCCCCCCCCEEE	61.27	OGP
832	Methylation	RPGSDPTKPDATLVV CCCCCCCCCCCEEEE	46.41	-
840	Methylation	PDATLVVKNHQLIVT CCCEEEEECCEEEEE	41.03	-
847	O-linked_Glycosylation	KNHQLIVTRGSQKDY ECCEEEEECCCCHHH	23.48	OGP
862	Phosphorylation	RKDASIGTKVVCWFV HHCCCCCCEEEEEEE	20.99	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITIH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITIH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITIH3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ITIH3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91 AND ASN-580, AND MASSSPECTROMETRY.
PubMed: 16335952