ARG33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARG33_HUMAN
• UniProt AC: A8MVX0
• Protein Name: Rho guanine nucleotide exchange factor 33
• Gene Name: ARHGEF33
• Organism: Homo sapiens (Human).
• Sequence Length: 844
• Protein Description: May act as a guanine-nucleotide releasing factor..
• Protein Sequence: MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWELEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAELLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADGVAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVRREMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGPWGWW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEKTKTKQGENEH --CCCCCCCCCCCCC	33.56	26434552
193	Phosphorylation	MGPGVNPTTPEAEEN CCCCCCCCCHHHHHH	50.18	22210691
194	Phosphorylation	GPGVNPTTPEAEENL CCCCCCCCHHHHHHH	22.01	22210691
203	Phosphorylation	EAEENLKSCLSADIQ HHHHHHHHHHHHHHH	24.37	22210691
268 (in isoform 2)	Phosphorylation	-	16.27	24719451
268	Phosphorylation	SLAAKRQTVALELLE HHHHHHHHHHHHHHH	16.27	24719451
276 (in isoform 2)	Phosphorylation	-	42.54	24719451
276	Phosphorylation	VALELLESERKYVIN HHHHHHHHCCCEEEE	42.54	24719451
280	Phosphorylation	LLESERKYVINISLI HHHHCCCEEEEEEEE	16.88	-
285	Phosphorylation	RKYVINISLILKIKA CCEEEEEEEEEEEEE	12.60	-
402	Phosphorylation	IVQRIPEYLIHLQNV HHHHHHHHHHHHHHH	12.95	-
420	Phosphorylation	TEQEHPDYYLLLVCV HCCCCCCCHHHHHHH	10.64	-
421	Phosphorylation	EQEHPDYYLLLVCVQ CCCCCCCHHHHHHHH	9.77	-
512	Phosphorylation	PSSGPAITHLMPPVK CCCCCCHHHCCCCCC	15.86	-
521	Phosphorylation	LMPPVKKSQQQQSLM CCCCCCHHHHHHHHH	27.75	29978859
526	Phosphorylation	KKSQQQQSLMESMQP CHHHHHHHHHHHCCC	25.91	29978859
530	Phosphorylation	QQQSLMESMQPGKPS HHHHHHHHCCCCCCC	14.57	29978859
537	Phosphorylation	SMQPGKPSDWELEGR HCCCCCCCCCCCCCC	59.86	29978859
551	Phosphorylation	RKHERPESLLAPTQF CCCCCCHHHCCCCHH	31.22	27282143
679	Phosphorylation	PLQPLPKSATSPAGS CCCCCCCCCCCCCCC	34.54	29396449
681	Phosphorylation	QPLPKSATSPAGSSS CCCCCCCCCCCCCCH	42.19	29396449
682	Phosphorylation	PLPKSATSPAGSSSA CCCCCCCCCCCCCHH	16.69	29396449
686	Phosphorylation	SATSPAGSSSAYKLE CCCCCCCCCHHHHHH	24.19	29396449
687	Phosphorylation	ATSPAGSSSAYKLEA CCCCCCCCHHHHHHH	20.33	29396449
688	Phosphorylation	TSPAGSSSAYKLEAA CCCCCCCHHHHHHHH	37.00	30576142
690	Phosphorylation	PAGSSSAYKLEAAAQ CCCCCHHHHHHHHHH	20.32	30576142
757	Methylation	AAAAVAARGASRTFF HHHHHHHHHHHCCCC	31.32	-
769	Phosphorylation	TFFPQQRSQSEKQTY CCCCHHCCCCHHHHH	33.45	-
771	Phosphorylation	FPQQRSQSEKQTYLE CCHHCCCCHHHHHHH	48.27	-
820	Phosphorylation	QKGGFRSSFRKLFKK CCCCHHHHHHHHHHH	25.47	17081983
832 (in isoform 2)	Phosphorylation	-	20.55	-
834 (in isoform 2)	Phosphorylation	-	30.02	-
838 (in isoform 2)	Phosphorylation	-	11.21	-
843 (in isoform 2)	Phosphorylation	-	8.17	-
847 (in isoform 2)	Phosphorylation	-		-
849 (in isoform 2)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARG33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARG33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARG33_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ARG33_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.