TRM7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRM7_HUMAN
• UniProt AC: Q9UET6
• Protein Name: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03162}
• Gene Name: FTSJ1 {ECO:0000255|HAMAP-Rule:MF_03162}
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Cytoplasm .
• Protein Description: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs..
• Protein Sequence: MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQKIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAKPRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDPDFNQLDGPTRIIVPFVTCGDLSSYDSDRSYPLDLEGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAKEIRPQDCPISRVDTFPQPLAAPQCHTLLAPEMEDNEMSCSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SKDKRDVYYRLAKEN CCCHHHHHHHHHHHH		-
28	Ubiquitination	WRARSAFKLLQLDKE CCHHHHHHHHHHCHH		-
34	Ubiquitination	FKLLQLDKEFQLFQG HHHHHHCHHHHHHHC		21890473
43	Phosphorylation	FQLFQGVTRAVDLCA HHHHHCCHHHHHHHC		27251275
164	Phosphorylation	IFRGRDVTLLYSQLQ ECCCCCCEEEHHHHH		22115753
167	Phosphorylation	GRDVTLLYSQLQVFF CCCCEEEHHHHHHHH		22115753
168	Phosphorylation	RDVTLLYSQLQVFFS CCCEEEHHHHHHHHH		22115753
175	Phosphorylation	SQLQVFFSSVLCAKP HHHHHHHHHHHCCCC		22115753
176	Phosphorylation	QLQVFFSSVLCAKPR HHHHHHHHHHCCCCC		22115753
210	Phosphorylation	EGFIPDLSKPLLDHS CCCCCCCCCCCCCCC		24719451
217 (in isoform 2)	Phosphorylation	-		25159151
217	Phosphorylation	SKPLLDHSYDPDFNQ CCCCCCCCCCCCHHH		25159151
258	Phosphorylation	PLDLEGGSEYKYTPP CCCCCCCCCCCCCCC		29978859
260	Phosphorylation	DLEGGSEYKYTPPTQ CCCCCCCCCCCCCCC		18669648
261	Sumoylation	LEGGSEYKYTPPTQP CCCCCCCCCCCCCCC		-
261	Ubiquitination	LEGGSEYKYTPPTQP CCCCCCCCCCCCCCC		-
262	Phosphorylation	EGGSEYKYTPPTQPP CCCCCCCCCCCCCCC		25159151
263	Phosphorylation	GGSEYKYTPPTQPPI CCCCCCCCCCCCCCC		28796482
266	Phosphorylation	EYKYTPPTQPPISPP CCCCCCCCCCCCCCC		28796482
271	Phosphorylation	PPTQPPISPPYQEAC CCCCCCCCCCHHHHH		25159151
274	Phosphorylation	QPPISPPYQEACTLK CCCCCCCHHHHHCHH		21712546
279	Phosphorylation	PPYQEACTLKRKGQL CCHHHHHCHHHCCCH		25159151
281	Methylation	YQEACTLKRKGQLAK HHHHHCHHHCCCHHH		-
288	Ubiquitination	KRKGQLAKEIRPQDC HHCCCHHHHCCCCCC		-
298	Phosphorylation	RPQDCPISRVDTFPQ CCCCCCCCCCCCCCC		26074081
302	Phosphorylation	CPISRVDTFPQPLAA CCCCCCCCCCCCCCC		20068231
314	Phosphorylation	LAAPQCHTLLAPEME CCCCCCCCEECCCCC		20068231
326	Phosphorylation	EMEDNEMSCSP---- CCCCCCCCCCC----		25159151
328	Phosphorylation	EDNEMSCSP------ CCCCCCCCC------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRM7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRM7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRM7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WDR6_HUMAN	WDR6	physical	26344197
DYSF_HUMAN	DYSF	physical	26496610
CDC37_HUMAN	CDC37	physical	26496610
WDR6_HUMAN	WDR6	physical	26496610
IBTK_HUMAN	IBTK	physical	26496610
SIR6_HUMAN	SIRT6	physical	26496610
GNL3L_HUMAN	GNL3L	physical	26496610
MRM1_HUMAN	MRM1	physical	26496610
ZFP91_HUMAN	ZFP91	physical	26496610
AROS_HUMAN	RPS19BP1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 309549: Mental retardation, X-linked 44 (MRX44)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.