| UniProt ID | AROS_HUMAN | |
|---|---|---|
| UniProt AC | Q86WX3 | |
| Protein Name | Active regulator of SIRT1 | |
| Gene Name | RPS19BP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 136 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.. | |
| Protein Sequence | MSAALLRRGLELLAASEAPRDPPGQAKPRGAPVKRPRKTKAIQAQKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAEGTVFTEEDFQKFQQEYFGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Citrullination | -MSAALLRRGLELLA -CCHHHHHHHHHHHH | 31.32 | - | |
| 7 | Methylation | -MSAALLRRGLELLA -CCHHHHHHHHHHHH | 31.32 | 115492559 | |
| 7 | Citrullination | -MSAALLRRGLELLA -CCHHHHHHHHHHHH | 31.32 | - | |
| 27 | Acetylation | RDPPGQAKPRGAPVK CCCCCCCCCCCCCCC | 27.62 | 26051181 | |
| 58 | Phosphorylation | AKGKVPKSALDEYRK CCCCCCHHHHHHHHH | 28.17 | - | |
| 63 | Phosphorylation | PKSALDEYRKRECRD CHHHHHHHHHHHHHH | 22.54 | - | |
| 77 | Ubiquitination | DHLRVNLKFLTRTRS HHHHHHHHHHHCCHH | 32.88 | - | |
| 80 | Phosphorylation | RVNLKFLTRTRSTVA HHHHHHHHCCHHHHH | 32.88 | - | |
| 82 | Phosphorylation | NLKFLTRTRSTVAES HHHHHHCCHHHHHHH | 24.60 | 28450419 | |
| 84 | Phosphorylation | KFLTRTRSTVAESVS HHHHCCHHHHHHHHH | 26.98 | 30266825 | |
| 85 | Phosphorylation | FLTRTRSTVAESVSQ HHHCCHHHHHHHHHH | 22.05 | 30266825 | |
| 89 | Phosphorylation | TRSTVAESVSQQILR CHHHHHHHHHHHHHH | 19.82 | 30266825 | |
| 91 | Phosphorylation | STVAESVSQQILRQN HHHHHHHHHHHHHHC | 26.16 | 20068231 | |
| 122 | Phosphorylation | KAEGTVFTEEDFQKF CCCCCEECHHHHHHH | 33.84 | 23312004 | |
| 128 | Ubiquitination | FTEEDFQKFQQEYFG ECHHHHHHHHHHHHC | 45.17 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AROS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AROS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AROS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SIR1_HUMAN | SIRT1 | physical | 17964266 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| DCTN6_HUMAN | DCTN6 | physical | 28514442 | |
| KBTB7_HUMAN | KBTBD7 | physical | 28514442 | |
| ARP10_HUMAN | ACTR10 | physical | 28514442 | |
| DCTN3_HUMAN | DCTN3 | physical | 28514442 | |
| DCTN2_HUMAN | DCTN2 | physical | 28514442 | |
| DCTN1_HUMAN | DCTN1 | physical | 28514442 | |
| KBTB6_HUMAN | KBTBD6 | physical | 28514442 | |
| DCTN4_HUMAN | DCTN4 | physical | 28514442 | |
| ACTY_HUMAN | ACTR1B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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