RYK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RYK_MOUSE
• UniProt AC: Q01887
• Protein Name: Tyrosine-protein kinase RYK
• Gene Name: Ryk
• Organism: Mus musculus (Mouse).
• Sequence Length: 594
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Nucleus . Cytoplasm . In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
• Protein Description: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development..
• Protein Sequence: MRAGRGGVPGSGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GRGGVPGSGGLRAPP CCCCCCCCCCCCCCC	24.50	28059163
123	N-linked_Glycosylation	AMGMPQVNISAQGEV EECCCCEEEEECCCC	19.76	-
149	Phosphorylation	SCTGKVDSEVMILMQ EECCCCCCEEEEEEE	34.77	25777480
158	N-linked_Glycosylation	VMILMQLNLTVNSSK EEEEEEEEEEECCCC	19.44	-
160	Phosphorylation	ILMQLNLTVNSSKNF EEEEEEEEECCCCCE	19.30	25777480
162	N-linked_Glycosylation	MQLNLTVNSSKNFTV EEEEEEECCCCCEEE	35.02	-
163	Phosphorylation	QLNLTVNSSKNFTVL EEEEEECCCCCEEEE	38.05	25777480
164	Phosphorylation	LNLTVNSSKNFTVLN EEEEECCCCCEEEEE	26.81	25777480
166	N-linked_Glycosylation	LTVNSSKNFTVLNFK EEECCCCCEEEEEEE	39.51	-
193	N-linked_Glycosylation	KTSALDKNTSRTIYD HHHHCCCCCCCCCCC	42.84	-
265	Phosphorylation	SQPSTQTTQYLRADT CCCCCCHHHEEECCC	12.85	20450229
267	Phosphorylation	PSTQTTQYLRADTPN CCCCHHHEEECCCCC	8.96	20450229
272	Phosphorylation	TQYLRADTPNNATPI HHEEECCCCCCCCCC	27.25	26824392
277	Phosphorylation	ADTPNNATPITSSSG CCCCCCCCCCCCCCC	19.83	29472430
313	Phosphorylation	KVKDIAISRERITLK HHHHHEEECCEEEHH	21.04	29514104
446	Methylation	GMSYLARREVIHRDL CCHHHHHHHHHHHHH	36.61	18962889
446	Dimethylation	GMSYLARREVIHRDL CCHHHHHHHHHHHHH	36.61	-
482	Phosphorylation	RDLFPMDYHCLGDNE CCCCCCCEECCCCCC	6.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RYK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RYK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RYK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT1_MOUSE	Wnt1	physical	15454084
WNT3A_MOUSE	Wnt3a	physical	15454084
DVL1_MOUSE	Dvl1	physical	15454084
CDC37_MOUSE	Cdc37	physical	19269974
EPHB3_MOUSE	Ephb3	physical	10932185
EPHA7_MOUSE	Epha7	physical	10932185
AFAD_MOUSE	Mllt4	physical	10932185

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.