AFAD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AFAD_MOUSE
• UniProt AC: Q9QZQ1
• Protein Name: Afadin
• Gene Name: Afdn {ECO:0000312|MGI:MGI:1314653}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1820
• Subcellular Localization: Cell junction, adherens junction. Not found at cell-matrix AJs.
• Protein Description: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm..
• Protein Sequence: MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPAKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKKEKEALRQASDKEERPSQGDDSENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDTADFAVAESLEKYGLEKENPKDYCIARVMLPPGAQHSDERGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDYIPKKMKKHVEGKSLKGKDRADGSGYGSALPPEKLPYLVELSPGRRNHFAYYSYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKFDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVDGQRISETTMLQSGMRLQFGTSHVFKFVDPIQDHVLSKRSVDGGLMVKGPRHKPGAVQETTFELGGDVHSGTALPASRSTTRLDSDRVSSASSTAERGMVKPMIRLDQEQEYRRRENRTQDATGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSSQHRPDISPTERTHKAIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVAVAENTADELARSDGRDVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLVPHTRSPGTWTIYFEGADYESHLMRENAELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSAQNGSPESPQMPWTEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKGPYTSGTAAKITSVSTGNLCTEEQSPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQSQWPNYEEKPHVHTESNHSSIAIQRVTRSQEELREEKVYQLERHRVEAGMDRKCDSDMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPVHYTSEFDGIPMDLPLPPPPANQAGPQSAQVAAAEWKKREEHQRWYEKEKARLEEERERKRREQERKLGQMRSQTLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIERKDLQYITISKEELSSGDSLSPDPWKRDAREKLEKQQQMHIVDMLSKEIHELQNKVDRTAEESDRLRKLMLEWQFQKRLQESKQKDEDDDEEEDDDVDTMLIMQRLEAERRARMQDEERRRQQQLEEMRKREAEDRVRQEEDGRHQEEERVKRDAEEKRRQEEGYYSRLEAERRRQHEEAARRLLEPEEPGLSRPPLPRDYEPPSLSSAPCAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYDEEEEDYGPAGPNSYSGSAGTAVGAYDAPREAREKLTRSQDADLPGSSGAPENLTFKERQRLFSQGQDVSDKVKASRKLTELENELNTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAGGRDEE ------CCCCCCHHH	47.10	28066266
90	Ubiquitination	MRMLSSPKYSLYEVH CHHHCCCCCEEEEEE	49.79	22790023
90 (in isoform 2)	Ubiquitination	-	49.79	22790023
91	Phosphorylation	RMLSSPKYSLYEVHV HHHCCCCCEEEEEEE	13.80	7071613
94	Phosphorylation	SSPKYSLYEVHVSGE CCCCCEEEEEEECCC	15.23	105683
160	Phosphorylation	VIQNFKRTLSKKEKK HHHHHHHHHCHHHHH	35.65	29514104
162	Phosphorylation	QNFKRTLSKKEKKEK HHHHHHHCHHHHHHH	40.86	44700773
181	Phosphorylation	KEALRQASDKEERPS HHHHHHCCCCCCCCC	40.66	25521595
188	Phosphorylation	SDKEERPSQGDDSEN CCCCCCCCCCCCCHH	53.68	59152049
193	Phosphorylation	RPSQGDDSENSRLAA CCCCCCCCHHHHHHH	43.34	21743459
196	Phosphorylation	QGDDSENSRLAAEVY CCCCCHHHHHHHHHH	25.31	21743459
203	Phosphorylation	SRLAAEVYKDMPETS HHHHHHHHCCCCCCC	7.87	105685
209	Phosphorylation	VYKDMPETSFTRTIS HHCCCCCCCCEECCC	24.22	23375375
210	Phosphorylation	YKDMPETSFTRTISN HCCCCCCCCEECCCC	23.98	23375375
212	Phosphorylation	DMPETSFTRTISNPE CCCCCCCEECCCCHH	27.03	23375375
214	Phosphorylation	PETSFTRTISNPEVV CCCCCEECCCCHHHH	26.21	24925903
216	Phosphorylation	TSFTRTISNPEVVMK CCCEECCCCHHHHHH	45.80	25521595
239	Phosphorylation	KRMQEFRSSDGRPDS HHHHHHHCCCCCCCC	37.79	29514104
240	Phosphorylation	RMQEFRSSDGRPDSG HHHHHHCCCCCCCCC	39.57	101545365
246	Phosphorylation	SSDGRPDSGGTLRIY CCCCCCCCCCEEEEE	41.63	26824392
249	Phosphorylation	GRPDSGGTLRIYADS CCCCCCCEEEEEECC	19.18	30635358
253	Phosphorylation	SGGTLRIYADSLKPN CCCEEEEEECCCCCC	9.64	15584949
256	Phosphorylation	TLRIYADSLKPNIPY EEEEEECCCCCCCCC	30.07	62170923
258	Ubiquitination	RIYADSLKPNIPYKT EEEECCCCCCCCCEE	39.71	22790023
258 (in isoform 2)	Ubiquitination	-	39.71	22790023
263	Phosphorylation	SLKPNIPYKTILLST CCCCCCCCEEEEEEC	19.57	29514104
309	Phosphorylation	LPPGAQHSDERGAKE CCCCCCCCCCCCCCE	29.14	26643407
315	Ubiquitination	HSDERGAKEIILDDD CCCCCCCCEEECCCC	52.88	22790023
315 (in isoform 2)	Ubiquitination	-	52.88	22790023
336	Acetylation	FREWPSDKGILVFQL HHHCCCCCCEEEEEE	52.79	23806337
336	Ubiquitination	FREWPSDKGILVFQL HHHCCCCCCEEEEEE	52.79	22790023
336 (in isoform 2)	Ubiquitination	-	52.79	22790023
350	Phosphorylation	LKRRPPDYIPKKMKK EECCCCCCCCHHHHH	25.54	29514104
363	Phosphorylation	KKHVEGKSLKGKDRA HHHCCCCCCCCCCCC	46.28	25266776
375	Phosphorylation	DRADGSGYGSALPPE CCCCCCCCCCCCCHH	15.03	29514104
383	Ubiquitination	GSALPPEKLPYLVEL CCCCCHHHCCEEEEE	61.61	22790023
383 (in isoform 2)	Ubiquitination	-	61.61	22790023
386	Phosphorylation	LPPEKLPYLVELSPG CCHHHCCEEEEECCC	33.54	29899451
391	Phosphorylation	LPYLVELSPGRRNHF CCEEEEECCCCCCCC	16.29	25521595
401	Phosphorylation	RRNHFAYYSYHTYED CCCCCEEEEEEECCC	10.18	50709205
424	Phosphorylation	KLYRLQLSVTEVGTE CEEEEEEEEEECCCC	17.65	25521595
426	Phosphorylation	YRLQLSVTEVGTEKF EEEEEEEEECCCCCC	22.90	28066266
430	Phosphorylation	LSVTEVGTEKFDDNS EEEEECCCCCCCCCC	40.97	63811387
494	Phosphorylation	MRLQFGTSHVFKFVD CEEECCCCCEEECCC	20.31	23567750
509	Phosphorylation	PIQDHVLSKRSVDGG HHHCCCCCCCCCCCC	25.57	1031630845
510	Malonylation	IQDHVLSKRSVDGGL HHCCCCCCCCCCCCE	44.52	26320211
512	Phosphorylation	DHVLSKRSVDGGLMV CCCCCCCCCCCCEEE	28.44	27149854
551	Phosphorylation	TALPASRSTTRLDSD CCCCCCCCCCCCCCC	31.47	22324799
552	Phosphorylation	ALPASRSTTRLDSDR CCCCCCCCCCCCCCC	18.15	51458597
553	Phosphorylation	LPASRSTTRLDSDRV CCCCCCCCCCCCCCC	30.40	23527152
557	Phosphorylation	RSTTRLDSDRVSSAS CCCCCCCCCCCCCCC	31.72	25521595
561	Phosphorylation	RLDSDRVSSASSTAE CCCCCCCCCCCHHHH	22.53	25521595
562	Phosphorylation	LDSDRVSSASSTAER CCCCCCCCCCHHHHC	29.34	25168779
564	Phosphorylation	SDRVSSASSTAERGM CCCCCCCCHHHHCCC	30.12	30352176
565	Phosphorylation	DRVSSASSTAERGMV CCCCCCCHHHHCCCC	31.21	23429704
566	Phosphorylation	RVSSASSTAERGMVK CCCCCCHHHHCCCCC	30.00	25521595
584	Phosphorylation	RLDQEQEYRRRENRT ECCHHHHHHHHHHCC	14.76	105687
644	Phosphorylation	VLYMACRYVLSSQHR HHHHHHHHHHHCCCC	12.96	25777480
647	Phosphorylation	MACRYVLSSQHRPDI HHHHHHHHCCCCCCC	20.22	24925903
648	Phosphorylation	ACRYVLSSQHRPDIS HHHHHHHCCCCCCCC	26.33	24925903
655	Phosphorylation	SQHRPDISPTERTHK CCCCCCCCCCHHHHH	32.90	24925903
657	Phosphorylation	HRPDISPTERTHKAI CCCCCCCCHHHHHHH	31.17	24925903
771	Phosphorylation	HTLTGAMSLLRRCRV HHHHHHHHHHHHHHH	24.58	28285833
998 (in isoform 2)	Ubiquitination	-	10.64	-
1013	Ubiquitination	EIITVTLKKQNGMGL CEEEEEEECCCCCCE	42.84	22790023
1013 (in isoform 2)	Ubiquitination	-	42.84	22790023
1026	Acetylation	GLSIVAAKGAGQDKL CEEEEEECCCCCCCC	39.29	19862063
1027 (in isoform 2)	Ubiquitination	-	30.16	-
1032	Acetylation	AKGAGQDKLGIYVKS ECCCCCCCCEEEEEE	40.50	19862077
1042	Ubiquitination	IYVKSVVKGGAADVD EEEEEEECCCCCCCC	49.85	22790023
1042 (in isoform 2)	Ubiquitination	-	49.85	22790023
1081	Phosphorylation	AAELMTRTSSVVTLE HHHHHHHCCCEEEHH	19.04	25521595
1082	Phosphorylation	AELMTRTSSVVTLEV HHHHHHCCCEEEHHH	20.18	24925903
1083	Phosphorylation	ELMTRTSSVVTLEVA HHHHHCCCEEEHHHH	21.72	25521595
1086	Phosphorylation	TRTSSVVTLEVAKQG HHCCCEEEHHHHHCC	18.29	25619855
1096	Phosphorylation	VAKQGAIYHGLATLL HHHCCHHHHHHHHHH	6.84	25777480
1101	Phosphorylation	AIYHGLATLLNQPSP HHHHHHHHHHCCCCH	36.50	25159016
1107	Phosphorylation	ATLLNQPSPMMQRIS HHHHCCCCHHHHHHH	18.70	25521595
1119	Phosphorylation	RISDRRGSGKPRPKS HHHCCCCCCCCCCCC	41.66	27149854
1126	Phosphorylation	SGKPRPKSEGFELYN CCCCCCCCCCCCCCC	45.71	27180971
1132	Phosphorylation	KSEGFELYNNSAQNG CCCCCCCCCCCCCCC	12.71	71857
1135	Phosphorylation	GFELYNNSAQNGSPE CCCCCCCCCCCCCCC	27.82	27180971
1140	Phosphorylation	NNSAQNGSPESPQMP CCCCCCCCCCCCCCC	32.80	15658135
1143	Phosphorylation	AQNGSPESPQMPWTE CCCCCCCCCCCCCCC	24.66	27087446
1149	Phosphorylation	ESPQMPWTEYSEPKK CCCCCCCCCCCCCCC	21.12	30635358
1151	Phosphorylation	PQMPWTEYSEPKKLP CCCCCCCCCCCCCCC	15.80	30635358
1152	Phosphorylation	QMPWTEYSEPKKLPG CCCCCCCCCCCCCCC	40.99	30635358
1172	Phosphorylation	KNRADHRSSPNVANQ HCCCCCCCCCCCCCC	46.88	25521595
1173	Phosphorylation	NRADHRSSPNVANQP CCCCCCCCCCCCCCC	22.05	25521595
1182	Phosphorylation	NVANQPPSPGGKGPY CCCCCCCCCCCCCCC	42.74	27087446
1189	Phosphorylation	SPGGKGPYTSGTAAK CCCCCCCCCCCCCEE	23.39	25619855
1190	Phosphorylation	PGGKGPYTSGTAAKI CCCCCCCCCCCCEEE	24.66	25619855
1191	Phosphorylation	GGKGPYTSGTAAKIT CCCCCCCCCCCEEEE	28.44	25619855
1193	Phosphorylation	KGPYTSGTAAKITSV CCCCCCCCCEEEEEE	24.18	25619855
1198	Phosphorylation	SGTAAKITSVSTGNL CCCCEEEEEEECCCC	23.51	24925903
1199	Phosphorylation	GTAAKITSVSTGNLC CCCEEEEEEECCCCC	19.97	24925903
1201	Phosphorylation	AAKITSVSTGNLCTE CEEEEEEECCCCCCC	30.29	25521595
1202	Phosphorylation	AKITSVSTGNLCTEE EEEEEEECCCCCCCC	28.12	24925903
1207	Phosphorylation	VSTGNLCTEEQSPPP EECCCCCCCCCCCCC	45.80	37009993
1211	Phosphorylation	NLCTEEQSPPPRPEA CCCCCCCCCCCCCCC	42.53	25521595
1219	Phosphorylation	PPPRPEAYPIPTQTY CCCCCCCCCCCCCCE	10.47	24925903
1222 (in isoform 2)	Ubiquitination	-	17.60	-
1223	Phosphorylation	PEAYPIPTQTYTREY CCCCCCCCCCEEEEE	33.97	25619855
1225	Phosphorylation	AYPIPTQTYTREYFT CCCCCCCCEEEEEEE	29.37	25619855
1226	Phosphorylation	YPIPTQTYTREYFTF CCCCCCCEEEEEEEC	8.25	25619855
1227	Phosphorylation	PIPTQTYTREYFTFP CCCCCCEEEEEEECC	22.03	25619855
1230	Phosphorylation	TQTYTREYFTFPASK CCCEEEEEEECCCCC	12.48	27180971
1232	Phosphorylation	TYTREYFTFPASKSQ CEEEEEEECCCCCCC	28.01	25521595
1236	Phosphorylation	EYFTFPASKSQDRMA EEEECCCCCCCCCCC	32.83	25168779
1237	Ubiquitination	YFTFPASKSQDRMAP EEECCCCCCCCCCCC	55.00	22790023
1237 (in isoform 2)	Ubiquitination	-	55.00	22790023
1238	Phosphorylation	FTFPASKSQDRMAPP EECCCCCCCCCCCCC	34.51	144369
1247	Phosphorylation	DRMAPPQSQWPNYEE CCCCCCHHHCCCCCC	39.73	25367039
1252	Phosphorylation	PQSQWPNYEEKPHVH CHHHCCCCCCCCCCC	22.76	25367039
1260	Phosphorylation	EEKPHVHTESNHSSI CCCCCCCCCCCCHHH	39.77	19367708
1262	Phosphorylation	KPHVHTESNHSSIAI CCCCCCCCCCHHHHH	40.78	19367708
1265	Phosphorylation	VHTESNHSSIAIQRV CCCCCCCHHHHHHHH	27.91	25367039
1273	Phosphorylation	SIAIQRVTRSQEELR HHHHHHHHCCHHHHH	27.13	22324799
1275	Phosphorylation	AIQRVTRSQEELREE HHHHHHCCHHHHHHH	32.36	25521595
1285	Phosphorylation	ELREEKVYQLERHRV HHHHHHCHHHHHHHH	20.60	91585
1302	Phosphorylation	GMDRKCDSDMWINQS CCCCCCCCCCEECCC	38.54	27087446
1309	Phosphorylation	SDMWINQSSSVESST CCCEECCCCCCCCCC	21.79	25777480
1310	Phosphorylation	DMWINQSSSVESSTS CCEECCCCCCCCCCC	28.74	29550500
1311	Phosphorylation	MWINQSSSVESSTSS CEECCCCCCCCCCCC	34.84	25777480
1314	Phosphorylation	NQSSSVESSTSSQEH CCCCCCCCCCCCHHH	36.44	29550500
1315	Phosphorylation	QSSSVESSTSSQEHL CCCCCCCCCCCHHHH	20.85	25777480
1316	Phosphorylation	SSSVESSTSSQEHLN CCCCCCCCCCHHHHC	41.50	29550500
1317	Phosphorylation	SSVESSTSSQEHLNH CCCCCCCCCHHHHCC	31.78	25777480
1318	Phosphorylation	SVESSTSSQEHLNHS CCCCCCCCHHHHCCC	39.41	27087446
1322 (in isoform 2)	Ubiquitination	-	6.41	-
1325	Phosphorylation	SQEHLNHSSKSVTPA CHHHHCCCCCCCCCC	38.09	29550500
1326	Phosphorylation	QEHLNHSSKSVTPAS HHHHCCCCCCCCCCH	22.77	25777480
1328	Phosphorylation	HLNHSSKSVTPASTL HHCCCCCCCCCCHHC	32.92	25521595
1330	Phosphorylation	NHSSKSVTPASTLTK CCCCCCCCCCHHCCC	21.89	25521595
1333	Phosphorylation	SKSVTPASTLTKSGP CCCCCCCHHCCCCCC	25.75	23984901
1334	Phosphorylation	KSVTPASTLTKSGPG CCCCCCHHCCCCCCC	40.32	25521595
1336	Phosphorylation	VTPASTLTKSGPGRW CCCCHHCCCCCCCCC	24.21	21082442
1337	Malonylation	TPASTLTKSGPGRWK CCCHHCCCCCCCCCC	57.43	26320211
1337	Ubiquitination	TPASTLTKSGPGRWK CCCHHCCCCCCCCCC	57.43	-
1337 (in isoform 2)	Ubiquitination	-	57.43	22790023
1452	Phosphorylation	SQTLNPASFSPLATQ HCCCCHHHCCCCCCC	27.75	26643407
1454	Phosphorylation	TLNPASFSPLATQAK CCCHHHCCCCCCCCC	19.26	26643407
1458	Phosphorylation	ASFSPLATQAKPEKP HHCCCCCCCCCCCCC	36.42	29899451
1466	Phosphorylation	QAKPEKPSTLQRPQE CCCCCCCCCCCCCHH	53.47	81116853
1467	Phosphorylation	AKPEKPSTLQRPQET CCCCCCCCCCCCHHH	35.12	23737553
1474	Phosphorylation	TLQRPQETVIRELQP CCCCCHHHHHHHCCC	18.91	29899451
1487	Phosphorylation	QPQQQPRTIERKDLQ CCCCCCCCCCHHCCE	33.60	26824392
1495	Phosphorylation	IERKDLQYITISKEE CCHHCCEEEEEEHHH	13.82	40429
1497	Phosphorylation	RKDLQYITISKEELS HHCCEEEEEEHHHHC	17.79	44702283
1499	Phosphorylation	DLQYITISKEELSSG CCEEEEEEHHHHCCC	25.93	25521595
1504	Phosphorylation	TISKEELSSGDSLSP EEEHHHHCCCCCCCC	35.24	26643407
1505	Phosphorylation	ISKEELSSGDSLSPD EEHHHHCCCCCCCCC	60.28	26643407
1508	Phosphorylation	EELSSGDSLSPDPWK HHHCCCCCCCCCHHH	33.98	26239621
1510	Phosphorylation	LSSGDSLSPDPWKRD HCCCCCCCCCHHHHH	31.07	27087446
1571	Phosphorylation	FQKRLQESKQKDEDD HHHHHHHHHHCCCCC	27.68	22324799
1654	Phosphorylation	KRRQEEGYYSRLEAE HHHHHHHHHHHHHHH	11.10	22601
1655	Phosphorylation	RRQEEGYYSRLEAER HHHHHHHHHHHHHHH	9.73	25367039
1656	Phosphorylation	RQEEGYYSRLEAERR HHHHHHHHHHHHHHH	23.16	25367039
1690	Phosphorylation	RPPLPRDYEPPSLSS CCCCCCCCCCCCCCC	31.45	25159016
1694	Phosphorylation	PRDYEPPSLSSAPCA CCCCCCCCCCCCCCC	52.15	-
1699 (in isoform 2)	Ubiquitination	-	19.42	-
1700	Glutathionylation	PSLSSAPCAPPPPPQ CCCCCCCCCCCCCCC	9.93	24333276
1711	Phosphorylation	PPPQRNASYLKTQVL CCCCCCHHHCEEEEC	34.25	24719451
1712	Phosphorylation	PPQRNASYLKTQVLS CCCCCHHHCEEEECC	15.14	29514104
1714	Ubiquitination	QRNASYLKTQVLSPD CCCHHHCEEEECCHH	28.78	22790023
1714 (in isoform 2)	Ubiquitination	-	28.78	22790023
1715	Phosphorylation	RNASYLKTQVLSPDS CCHHHCEEEECCHHH	22.70	28833060
1719	Phosphorylation	YLKTQVLSPDSLFTA HCEEEECCHHHHEEE	28.01	25521595
1722	Phosphorylation	TQVLSPDSLFTAKFV EEECCHHHHEEEEEE	28.85	25521595
1725	Phosphorylation	LSPDSLFTAKFVAYD CCHHHHEEEEEEEEC	33.94	28833060
1757	Phosphorylation	AGTAVGAYDAPREAR CCCCCCCCCCCHHHH	13.50	30990501
1768	Phosphorylation	REAREKLTRSQDADL HHHHHHHHHHCCCCC	39.07	26239621
1770	Phosphorylation	AREKLTRSQDADLPG HHHHHHHHCCCCCCC	27.46	27742792
1778	Phosphorylation	QDADLPGSSGAPENL CCCCCCCCCCCCCCC	24.53	25619855
1779	Phosphorylation	DADLPGSSGAPENLT CCCCCCCCCCCCCCC	44.91	23984901
1795	Phosphorylation	KERQRLFSQGQDVSD HHHHHHHHCCCCHHH	37.68	25521595
1801	Phosphorylation	FSQGQDVSDKVKASR HHCCCCHHHHHHHHH	39.75	25619855
1803	Acetylation	QGQDVSDKVKASRKL CCCCHHHHHHHHHHH	37.82	23806337
1811	Phosphorylation	VKASRKLTELENELN HHHHHHHHHHHHHHC	41.37	26239621
1820	Acetylation	LENELNTK------- HHHHHCCC-------	58.21	15618639

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AFAD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AFAD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AFAD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYK_MOUSE	Ryk	physical	10932185

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1182, ANDMASS SPECTROMETRY.
PubMed: 19131326

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107; SER-1182 ANDSER-1275, AND MASS SPECTROMETRY.
PubMed: 19367708