EPHA7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPHA7_MOUSE
• UniProt AC: Q61772
• Protein Name: Ephrin type-A receptor 7
• Gene Name: Epha7
• Organism: Mus musculus (Mouse).
• Sequence Length: 998
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties..
• Protein Sequence: MVVQTRFPSWIILCYIWLLGFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPSGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIVENLAVFPDTVTGSEFSSLVEVRGTCVSSAEEEAENSPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRRFYKSSSQDLQCSRCPTHSFSDREGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVQLSWQEPEHPNGVITEYEIKYYEKDQRERTYSTLKTKSTSASINNLKPGTVYVFQIRAVTAAGYGNYSPRLDVATLEEASGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMIRNPSSLKTPLGTCSRPLSPLLDQSTPDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Phosphorylation	SLVEVRGTCVSSAEE HCEEEECEECCCHHH	10.12	23984901
236	Phosphorylation	EVRGTCVSSAEEEAE EEECEECCCHHHHHH	26.44	23984901
237	Phosphorylation	VRGTCVSSAEEEAEN EECEECCCHHHHHHH	21.21	23984901
251	Phosphorylation	NSPRMHCSAEGEWLV HCCCCEECCCCCEEE	18.06	23984901
343	N-linked_Glycosylation	QNLIFNINQTTVSLE CCEEEEECCCEEEEE	33.96	-
410	N-linked_Glycosylation	MDLLAHANYTFEVEA HHHHHHCCEEEEEEE	26.89	-
435	Phosphorylation	QRLFAAVSITTGQAA HHHEEEEEEECCCCC	14.97	-
437	Phosphorylation	LFAAVSITTGQAAPS HEEEEEEECCCCCHH	19.84	-
438	Phosphorylation	FAAVSITTGQAAPSQ EEEEEEECCCCCHHH	26.15	-
444	Phosphorylation	TTGQAAPSQVSGVMK ECCCCCHHHCCHHHH	38.19	28059163
447	Phosphorylation	QAAPSQVSGVMKERV CCCHHHCCHHHHHHH	20.31	28059163
607	Phosphorylation	FKFPGTKTYIDPETY EECCCCCCEECHHHC	26.08	24759943
608	Phosphorylation	KFPGTKTYIDPETYE ECCCCCCEECHHHCC	12.60	-
614	Phosphorylation	TYIDPETYEDPNRAV CEECHHHCCCCCHHH	19.37	-
653	Acetylation	EVCSGRLKLPGKRDV CCCCCCCCCCCCHHH	51.80	7626461
780	Phosphorylation	KVSDFGLSRVIEDDP EECHHCCCEEECCCC	25.53	22817900
791	Phosphorylation	EDDPEAVYTTTGGKI CCCCCCEEECCCCCC	12.86	26824392
810	Phosphorylation	TAPEAIQYRKFTSAS ECCHHHHCCCCCCHH	15.06	10572014
940	Phosphorylation	QAIKMERYKDNFTAA HHHHHHHCCCCCCHH	14.91	-
951	Phosphorylation	FTAAGYNSLESVARM CCHHCCCCHHHHHCC	25.65	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPHA7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPHA7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPHA7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EPHA7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.