dbPTM

WNT3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WNT3A_MOUSE
UniProt AC	P27467
Protein Name	Protein Wnt-3a
Gene Name	Wnt3a
Organism	Mus musculus (Mouse).
Sequence Length	352
Subcellular Localization	Secreted, extracellular space, extracellular matrix . Secreted .
Protein Description	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. [PubMed: 26902720 Required for normal embryonic mesoderm development and formation of caudal somites]
Protein Sequence	MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	S-palmitoylation	VKAGIQECQHQFRGR HHHHHHHHHHHHCCC	2.22	12717451
87	N-linked_Glycosylation	QFRGRRWNCTTVSNS HHCCCCCCCEECCCC	16.08	-
209	O-palmitoleoylation	KCKCHGLSGSCEVKT EEEECCCCCCCEEEE	33.00	25771893
298	N-linked_Glycosylation	GTRDRTCNVSSHGID CCCCCCCCCCCCCCC	35.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WNT3A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WNT3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WNT3A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DKK1_MOUSE	Dkk1	genetic	15143170

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WNT3A_MOUSE

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"Wnt proteins are lipid-modified and can act as stem cell growthfactors."; Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L.,Reya T., Yates J.R. III, Nusse R.; Nature 423:448-452(2003). Cited for: PALMITOYLATION AT CYS-77.	12717451 [Abstract]