GDF15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDF15_HUMAN
• UniProt AC: Q99988
• Protein Name: Growth/differentiation factor 15 {ECO:0000305}
• Gene Name: GDF15 {ECO:0000312|HGNC:HGNC:30142}
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Secreted .
• Protein Description: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. [PubMed: 28953886]
• Protein Sequence: MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRYEDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	O-linked_Glycosylation	LAEASRASFPGPSEL HHHHHHCCCCCCHHH	30.75	OGP
44	O-linked_Glycosylation	RASFPGPSELHSEDS HCCCCCCHHHCCCCH	59.72	55828353
48	O-linked_Glycosylation	PGPSELHSEDSRFRE CCCHHHCCCCHHHHH	56.58	OGP
70	N-linked_Glycosylation	LLTRLRANQSWEDSN HHHHHHHCCCCCCCC	29.95	UniProtKB CARBOHYD
70	N-linked_Glycosylation	LLTRLRANQSWEDSN HHHHHHHCCCCCCCC	29.95	10811612
72	Phosphorylation	TRLRANQSWEDSNTD HHHHHCCCCCCCCCC	32.04	28985074
78	Phosphorylation	QSWEDSNTDLVPAPA CCCCCCCCCCCCCCC	34.36	24719451
146	Phosphorylation	RPLRRQLSLARPQAP HHHHHHHHCCCCCCC	16.19	26091039
160	Phosphorylation	PALHLRLSPPPSQSD CEEEEEECCCCCHHH	29.00	25850435
164	Phosphorylation	LRLSPPPSQSDQLLA EEECCCCCHHHHHHH	48.35	25850435
166	Phosphorylation	LSPPPSQSDQLLAES ECCCCCHHHHHHHHC	31.49	25850435
173	Phosphorylation	SDQLLAESSSARPQL HHHHHHHCCCCCCCC	24.80	29978859
174	Phosphorylation	DQLLAESSSARPQLE HHHHHHCCCCCCCCH	21.37	29978859
175	Phosphorylation	QLLAESSSARPQLEL HHHHHCCCCCCCCHH	37.26	29978859
265	Ubiquitination	KTSLHRLKPDTVPAP HHHHHHCCCCCCCCC	40.58	21906983
303	Ubiquitination	TYDDLLAKDCHCI-- CHHHHHHHHCCCC--	61.94	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:18927080

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDF15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDF15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDF15_HUMAN	GDF15	physical	10811612
GDF15_HUMAN	GDF15	physical	9326641
MDFI_HUMAN	MDFI	physical	19060904

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.