CDC42_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC42_MOUSE
• UniProt AC: P60766
• Protein Name: Cell division control protein 42 homolog
• Gene Name: Cdc42
• Organism: Mus musculus (Mouse).
• Sequence Length: 191
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytopla
• Protein Description: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. [PubMed: 25851601 Facilitates filopodia formation upon DOCK11-activation]
• Protein Sequence: MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MQTIKCVVVGDG ---CCEEEEEEECCC	25.10	22826441
6	S-nitrosocysteine	--MQTIKCVVVGDGA --CCEEEEEEECCCC	2.19	-
6	S-nitrosylation	--MQTIKCVVVGDGA --CCEEEEEEECCCC	2.19	20925432
6	Glutathionylation	--MQTIKCVVVGDGA --CCEEEEEEECCCC	2.19	24333276
17	Phosphorylation	GDGAVGKTCLLISYT CCCCCCCEEEEEEEE	11.49	22802335
22	Phosphorylation	GKTCLLISYTTNKFP CCEEEEEEEECCCCC	19.18	22802335
23	Phosphorylation	KTCLLISYTTNKFPS CEEEEEEEECCCCCH	15.58	22802335
24	Phosphorylation	TCLLISYTTNKFPSE EEEEEEEECCCCCHH	19.66	22802335
25	Phosphorylation	CLLISYTTNKFPSEY EEEEEEECCCCCHHH	28.33	22802335
30	Phosphorylation	YTTNKFPSEYVPTVF EECCCCCHHHCCCEE	44.70	22802335
32	Phosphorylation	TNKFPSEYVPTVFDN CCCCCHHHCCCEECC	18.96	22802335
35	Phosphorylation	FPSEYVPTVFDNYAV CCHHHCCCEECCEEE	24.62	22802335
40	Phosphorylation	VPTVFDNYAVTVMIG CCCEECCEEEEEEEC	12.32	22802335
43	Phosphorylation	VFDNYAVTVMIGGEP EECCEEEEEEECCEE	9.00	22802335
51	Phosphorylation	VMIGGEPYTLGLFDT EEECCEEEEEEEECC	15.42	22802335
52	Phosphorylation	MIGGEPYTLGLFDTA EECCEEEEEEEECCC	25.68	22802335
58	Phosphorylation	YTLGLFDTAGQEDYD EEEEEECCCCCCCHH	25.92	22802335
64	Phosphorylation	DTAGQEDYDRLRPLS CCCCCCCHHHCCCCC	11.38	22802335
88	Phosphorylation	CFSVVSPSSFENVKE EEEECCHHHHHCHHH	39.90	22802335
89	Phosphorylation	FSVVSPSSFENVKEK EEECCHHHHHCHHHH	39.71	22802335
96	Ubiquitination	SFENVKEKWVPEITH HHHCHHHHCCCCHHC	48.01	22790023
105	S-nitrosocysteine	VPEITHHCPKTPFLL CCCHHCCCCCCCEEE	2.61	-
105	Glutathionylation	VPEITHHCPKTPFLL CCCHHCCCCCCCEEE	2.61	24333276
105	S-nitrosylation	VPEITHHCPKTPFLL CCCHHCCCCCCCEEE	2.61	20925432
128	Ubiquitination	DDPSTIEKLAKNKQK CCHHHHHHHHHCCCC	50.31	22790023
133	Ubiquitination	IEKLAKNKQKPITPE HHHHHHCCCCCCCHH	60.02	22790023
135	Ubiquitination	KLAKNKQKPITPETA HHHHCCCCCCCHHHH	39.74	27667366
135	Acetylation	KLAKNKQKPITPETA HHHHCCCCCCCHHHH	39.74	23201123
135	Malonylation	KLAKNKQKPITPETA HHHHCCCCCCCHHHH	39.74	26320211
141	Phosphorylation	QKPITPETAEKLARD CCCCCHHHHHHHHHH	41.12	28464351
144	Ubiquitination	ITPETAEKLARDLKA CCHHHHHHHHHHHHH	45.01	22790023
144	Acetylation	ITPETAEKLARDLKA CCHHHHHHHHHHHHH	45.01	23201123
150	Ubiquitination	EKLARDLKAVKYVEC HHHHHHHHHCCEEEC	56.26	27667366
153	Ubiquitination	ARDLKAVKYVECSAL HHHHHHCCEEECHHH	48.73	22790023
153	Acetylation	ARDLKAVKYVECSAL HHHHHHCCEEECHHH	48.73	22826441
153 (in isoform 1)	Ubiquitination	-	48.73	22790023
157	S-nitrosylation	KAVKYVECSALTQKG HHCCEEECHHHCHHH	1.74	20925432
157	S-nitrosocysteine	KAVKYVECSALTQKG HHCCEEECHHHCHHH	1.74	-
158	Phosphorylation	AVKYVECSALTQKGL HCCEEECHHHCHHHH	16.89	-
163	Succinylation	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	-
163	Acetylation	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	23806337
163	Malonylation	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	26320211
163	Ubiquitination	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	-
183	Ubiquitination	ALEPPEPKKSRRCVL HHCCCCCCCCCCEEE	62.81	22790023
184	Ubiquitination	LEPPEPKKSRRCVLL HCCCCCCCCCCEEEC	60.97	22790023
185 (in isoform 1)	Ubiquitination	-	30.96	-
188	Geranylgeranylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	-
188	Methylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	-
188	S-palmitoylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	24059268
189	S-palmitoylation	PKKSRRCVLL----- CCCCCCEEEC-----	6.06	24059268

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC42_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC42_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DOC11_MOUSE	Dock11	physical	15710388
LIS1_MOUSE	Pafah1b1	physical	16369480
IQGA1_MOUSE	Iqgap1	physical	16369480
SRGP1_MOUSE	Srgap1	physical	11672528

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.