IQGA1_MOUSE - dbPTM
IQGA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IQGA1_MOUSE
UniProt AC Q9JKF1
Protein Name Ras GTPase-activating-like protein IQGAP1
Gene Name Iqgap1
Organism Mus musculus (Mouse).
Sequence Length 1657
Subcellular Localization Cell membrane . Nucleus . Cytoplasm . Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).
Protein Description Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. [PubMed: 16968698 It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.]
Protein Sequence MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRVAADTFTALKNPNAMLVNLEEGLAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANISLALEQGCAVTLLKALQSLALGLRGLQTQNSDWYMKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANSAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMTTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNAFITWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGISAINEAVDSGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQVACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAAEEVDG
------CCHHHCCCC		47.7126824392
2Acetylation------MSAAEEVDG
------CCHHHCCCC		47.71-
17PhosphorylationLGVVRPHYGSVLDNE
CCCCCCCCCCCCCCC		17.4925367039
19PhosphorylationVVRPHYGSVLDNERL
CCCCCCCCCCCCCCC		16.6125367039
104AcetylationDREQTRYKATGLHFR
CCCHHHHHCCCCCCC		35.8622826441
113PhosphorylationTGLHFRHTDNVIQWL
CCCCCCCHHHHHHHH		25.6425177544
172PhosphorylationAPQIQDLYGKVDFTE
CHHHHHHHCCCCCCH		24.1625159016
178PhosphorylationLYGKVDFTEEEINNM
HHCCCCCCHHHHHHH		37.7123608596
192PhosphorylationMKIELEKYGIQMPAF
HEEEHHHHCCCCCHH		15.3029514104
211PhosphorylationGILANELSVDEAALH
CHHHHCCCCCHHHHH		22.7326824392
271PhosphorylationQAKQDKMTNAKNRTE
HHHHHHCCCCCCCCC		37.4519144319
277PhosphorylationMTNAKNRTENSDRER
CCCCCCCCCCCHHHH		49.2425338131
287PhosphorylationSDRERDVYEELLTQA
CHHHHHHHHHHHHHH		14.1528725479
330PhosphorylationTLLKALQSLALGLRG
HHHHHHHHHHHHHCC		19.23-
360PhosphorylationDLQQKRQSGQTDPLQ
HHHHHHHCCCCCHHH		36.5828418008
363PhosphorylationQKRQSGQTDPLQKEE
HHHHCCCCCHHHHHH		43.0128066266
469PhosphorylationLINRALESGDMTTVW
HHHHHHHCCCHHHHH		40.7328066266
473PhosphorylationALESGDMTTVWKQLS
HHHCCCHHHHHHHHH		23.9628066266
474PhosphorylationLESGDMTTVWKQLSS
HHCCCHHHHHHHHHC		20.1028066266
481PhosphorylationTVWKQLSSSVTGLTN
HHHHHHHCCCCCCCC		37.1025338131
482PhosphorylationVWKQLSSSVTGLTNI
HHHHHHCCCCCCCCC		21.9625338131
503UbiquitinationRYLDELMKLKAQAHA
HHHHHHHHHHHHHHH		60.50-
582PhosphorylationVAQHYQDTLIRAKRE
HHHHHHHHHHHHHHH		14.4626824392
642PhosphorylationDSGDVGRTLSALRSP
HCCCHHHHHHHHHCC		21.0923984901
644PhosphorylationGDVGRTLSALRSPDV
CCHHHHHHHHHCCCC		25.3323984901
648PhosphorylationRTLSALRSPDVGLYG
HHHHHHHCCCCEEEE		26.7123984901
654PhosphorylationRSPDVGLYGVIPECG
HCCCCEEEEECCCCC		11.9223984901
684AcetylationAAGDNNSKWVKHWVK
CCCCCCCHHHHHHHH		59.1222826441
801PhosphorylationAYQDRLAYLHSHKDE
HHHHHHHHHHHCCHH		15.0029514104
814PhosphorylationDEVVKIQSLARMHQA
HHHHHHHHHHHHHHH		27.7227600695
841UbiquitinationDHINDIIKIQAFIRA
HHHHHHHHHHHHHHH		29.15-
855PhosphorylationANKARDDYKTLINAE
HHCCCHHHHHHCCCC		15.3425367039
871AcetylationPPMIVVRKFVHLLDQ
CCEEEEEHHHHHHCC		39.8822826441
934PhosphorylationLQDVVSHSKKLTKKN
HHHHHHHHHHHCCCC		24.7927841257
940UbiquitinationHSKKLTKKNKEQLSD
HHHHHCCCCHHHHHH		68.93-
959AcetylationNKQKGGLKALSKEKR
HHHCCHHHHCCHHHH		51.0212439089
963AcetylationGGLKALSKEKREKLE
CHHHHCCHHHHHHHH		69.0112439101
965AcetylationLKALSKEKREKLEAY
HHHCCHHHHHHHHHH		70.3712439113
968AcetylationLSKEKREKLEAYQHL
CCHHHHHHHHHHHHH		56.5122826441
997UbiquitinationIFQMPQNKSTKFMDS
HHCCCCCCCCCCHHH		55.01-
1057PhosphorylationTVIKMVVSFNRGARG
CEEEEEEECCCCCHH		12.8529472430
1088AcetylationDDKSLNIKTDPVDIY
CCCCCCCCCCHHHHH		45.8923236377
1097PhosphorylationDPVDIYKSWVNQMES
CHHHHHHHHHHHHHH		21.2019060867
1111UbiquitinationSQTGEASKLPYDVTP
HCCCCCCCCCCCCCH		61.60-
1114PhosphorylationGEASKLPYDVTPEQA
CCCCCCCCCCCHHHC		33.2229514104
1134PhosphorylationVKTRLDNSIRNMRAV
HHHHHHHHHHHHHHH		23.6928464351
1144AcetylationNMRAVTDKFLSAIVS
HHHHHHHHHHHHHHH		38.5522826441
1147PhosphorylationAVTDKFLSAIVSSVD
HHHHHHHHHHHHHHH		21.0522418434
1151PhosphorylationKFLSAIVSSVDKIPY
HHHHHHHHHHHCCCH		20.6626643407
1152PhosphorylationFLSAIVSSVDKIPYG
HHHHHHHHHHCCCHH		24.3626643407
1155UbiquitinationAIVSSVDKIPYGMRF
HHHHHHHCCCHHHHH		43.34-
1168UbiquitinationRFIAKVLKDSLHEKF
HHHHHHHHHHHHHHC		48.54-
1174AcetylationLKDSLHEKFPDAGED
HHHHHHHHCCCCCHH		51.9922826441
1389UbiquitinationRTILLNTKRLIVDVI
HHHHHCCCHHHEEEE		44.10-
1405PhosphorylationFQPGETLTEILETPA
CCCCCCHHHHHHCCC		28.5325338131
1434PhosphorylationRAIRDAKTPDKMKKS
HHHHHCCCCCHHHCC		38.1426824392
1441PhosphorylationTPDKMKKSKPMKEDN
CCCHHHCCCCCCCCC		36.1525338131
1465UbiquitinationKIQTGLKKLTELGTV
HHHHHHHHHHHCCCC		66.73-
1475UbiquitinationELGTVDPKNRYQELI
HCCCCCCCHHHHHHH		49.98-
1509PhosphorylationELVKLQQTYSALNSK
HHHHHHHHHHHHHCC		13.3928833060
1510PhosphorylationLVKLQQTYSALNSKA
HHHHHHHHHHHHCCC		6.3927742792
1511PhosphorylationVKLQQTYSALNSKAT
HHHHHHHHHHHCCCC		29.6628833060
1515PhosphorylationQTYSALNSKATFYGE
HHHHHHHCCCCCCHH		25.2328833060
1526PhosphorylationFYGEQVDYYKSYIKT
CCHHHHHHHHHHHHH		17.59-
1528AcetylationGEQVDYYKSYIKTCL
HHHHHHHHHHHHHHH		30.4722826441
1528UbiquitinationGEQVDYYKSYIKTCL
HHHHHHHHHHHHHHH		30.47-
1532AcetylationDYYKSYIKTCLDNLA
HHHHHHHHHHHHHHH		25.5922826441
1540PhosphorylationTCLDNLASKGKVSKK
HHHHHHHHCCCCCCC		45.14-
1562AcetylationKSKKISLKYTAARLH
CCCCCCHHHHHHHHH		33.4922826441
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IQGA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IQGA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IQGA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLIP1_MOUSEClip1physical
16369480
LIS1_MOUSEPafah1b1physical
16369480
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IQGA1_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-271, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory