SRGP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRGP1_MOUSE
• UniProt AC: Q91Z69
• Protein Name: SLIT-ROBO Rho GTPase-activating protein 1
• Gene Name: Srgap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1062
• Protein Description: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity)..
• Protein Sequence: MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTSRGRRNSHARHQDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLSDEQSNHDINSVAGVLKLYFRGLENPLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRGSEPQIRRSTSSSSETMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTMGPAAPSQGPTDKSCTM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
213	Phosphorylation	EERHQRRSSVKKIEK HHHHHHHHHHHHHHH	41.49	-
214	Phosphorylation	ERHQRRSSVKKIEKM HHHHHHHHHHHHHHH	35.82	-
396	Phosphorylation	DMVTIEDYDVSECFQ HCCCCCCCCHHHHHH	12.88	29899451
405	Phosphorylation	VSECFQHSRSTESVK HHHHHHCCCCCHHHH	19.69	29899451
407	Phosphorylation	ECFQHSRSTESVKST HHHHCCCCCHHHHHH	39.27	29899451
410	Phosphorylation	QHSRSTESVKSTVSE HCCCCCHHHHHHHCH	34.63	29899451
413	Phosphorylation	RSTESVKSTVSETYL CCCHHHHHHHCHHHH	31.70	24759943
414	Phosphorylation	STESVKSTVSETYLS CCHHHHHHHCHHHHC	23.49	24759943
416	Phosphorylation	ESVKSTVSETYLSKP HHHHHHHCHHHHCCH	25.06	22807455
419	Phosphorylation	KSTVSETYLSKPSIA HHHHCHHHHCCHHHH	12.62	28576409
421	Phosphorylation	TVSETYLSKPSIAKR HHCHHHHCCHHHHHH	31.91	24759943
424	Phosphorylation	ETYLSKPSIAKRRAN HHHHCCHHHHHHHCC	38.63	24759943
485	Phosphorylation	TSRGRRNSHARHQDS CCCCCCCCCCCCCCC	19.40	-
492	Phosphorylation	SHARHQDSGQVIPLI CCCCCCCCCCHHHHH	25.26	-
521	Phosphorylation	HQGIFRVSGSQVEVN CCEEEEEECCEEEHH	28.59	20415495
523	Phosphorylation	GIFRVSGSQVEVNDI EEEEEECCEEEHHHH	24.44	20415495
793	Phosphorylation	TLSQKADSEASSGPV HHHHHCCCCHHCCCC	39.66	25195567
796	Phosphorylation	QKADSEASSGPVTED HHCCCCHHCCCCCCC	31.60	25195567
797	Phosphorylation	KADSEASSGPVTEDK HCCCCHHCCCCCCCC	54.91	25195567
801	Phosphorylation	EASSGPVTEDKSSSK CHHCCCCCCCCCCCC	41.42	22942356
806	Phosphorylation	PVTEDKSSSKDMNSP CCCCCCCCCCCCCCC	47.34	22942356
807	Phosphorylation	VTEDKSSSKDMNSPT CCCCCCCCCCCCCCC	39.50	22942356
812	Phosphorylation	SSSKDMNSPTDRHSD CCCCCCCCCCCCCCH	23.65	25521595
814	Phosphorylation	SKDMNSPTDRHSDSY CCCCCCCCCCCCHHH	45.55	25521595
883	Phosphorylation	NRGLNNDSPERRRRP CCCCCCCCHHHHCCC	30.68	25521595
894	Phosphorylation	RRRPGHGSLTNISRH HCCCCCCCCCCCCCC	26.75	19060867
903	Phosphorylation	TNISRHDSLKKIDSP CCCCCCCCCCCCCCC	35.64	21082442
909	Phosphorylation	DSLKKIDSPPIRRST CCCCCCCCCCCCCCC	35.73	27899381
915	Phosphorylation	DSPPIRRSTSSGQYT CCCCCCCCCCCCCCC	23.85	26160508
916	Phosphorylation	SPPIRRSTSSGQYTG CCCCCCCCCCCCCCC	25.71	26160508
917	Phosphorylation	PPIRRSTSSGQYTGF CCCCCCCCCCCCCCC	33.45	26160508
918	Phosphorylation	PIRRSTSSGQYTGFN CCCCCCCCCCCCCCC	29.97	26160508
921	Phosphorylation	RSTSSGQYTGFNDHK CCCCCCCCCCCCCCC	16.62	26160508
922	Phosphorylation	STSSGQYTGFNDHKP CCCCCCCCCCCCCCC	27.66	26160508
976	Phosphorylation	TLEQVKNSPTPATST HHHHHHCCCCCCCCC	25.16	20415495
978	Phosphorylation	EQVKNSPTPATSTES HHHHCCCCCCCCCCC	25.94	21659605
981	Phosphorylation	KNSPTPATSTESLSP HCCCCCCCCCCCCCC	37.07	20415495
982	O-linked_Glycosylation	NSPTPATSTESLSPL CCCCCCCCCCCCCCC	32.08	22645316
982	Phosphorylation	NSPTPATSTESLSPL CCCCCCCCCCCCCCC	32.08	27087446
983	Phosphorylation	SPTPATSTESLSPLH CCCCCCCCCCCCCCC	25.82	30372032
985	Phosphorylation	TPATSTESLSPLHNV CCCCCCCCCCCCCCC	33.95	30372032
987	Phosphorylation	ATSTESLSPLHNVAL CCCCCCCCCCCCCHH	34.39	25521595
1004	Phosphorylation	SEPQIRRSTSSSSET CCCCHHCCCCCCCCH	23.85	-
1005	Phosphorylation	EPQIRRSTSSSSETM CCCHHCCCCCCCCHH	30.71	-
1006	Phosphorylation	PQIRRSTSSSSETMS CCHHCCCCCCCCHHH	29.48	25338131
1009	Phosphorylation	RRSTSSSSETMSTFK HCCCCCCCCHHHHCC	38.75	25338131
1014	Phosphorylation	SSSETMSTFKPMVAP CCCCHHHHCCCCCCC	25.51	28576409
1042	Phosphorylation	KPAVLPKTNPTMGPA CCCCCCCCCCCCCCC	44.48	23527152
1061	Phosphorylation	GPTDKSCTM------ CCCCCCCCC------	32.76	23527152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRGP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRGP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRGP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRGP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.