DOC11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOC11_MOUSE
• UniProt AC: A2AF47
• Protein Name: Dedicator of cytokinesis protein 11 {ECO:0000312|MGI:MGI:1923224}
• Gene Name: Dock11 {ECO:0000312|MGI:MGI:1923224}
• Organism: Mus musculus (Mouse).
• Sequence Length: 2073
• Protein Description: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. [PubMed: 15710388]
• Protein Sequence: MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RKFTKRLSKPGTAAE HHHHHHHCCCCCHHH	40.62	26824392
16	Phosphorylation	KRLSKPGTAAELRQS HHHCCCCCHHHHHHH	31.08	28833060
23	Phosphorylation	TAAELRQSVSEAVRG CHHHHHHHHHHHHHC	22.60	26824392
57	Phosphorylation	TQRKTQIYSDPLRDL CCCCCCCCCCCHHHH	9.37	25263469
58	Phosphorylation	QRKTQIYSDPLRDLL CCCCCCCCCCHHHHH	34.09	25367039
156	Phosphorylation	DCEKDEDSSSLCSQK CCCCCCCCCCCHHHC	21.56	29550500
157	Phosphorylation	CEKDEDSSSLCSQKG CCCCCCCCCCHHHCC	39.38	29550500
158	Phosphorylation	EKDEDSSSLCSQKGG CCCCCCCCCHHHCCC	37.03	25521595
161	Phosphorylation	EDSSSLCSQKGGVIK CCCCCCHHHCCCEEE	39.97	30635358
163	Acetylation	SSSLCSQKGGVIKQG CCCCHHHCCCEEEEC	41.14	7718415
180	Phosphorylation	HKANVNSTITVTMKV ECCCCCCEEEEEEEE	18.57	25338131
248	Phosphorylation	ELKMLDKYSHYLAAE HHHHHHHHHHHHHHC	10.59	-
285	Phosphorylation	LVQEKKDTVEAIQEE HHHHCHHHHHHHHHH	29.17	-
294	Phosphorylation	EAIQEEETSSQGKAE HHHHHHHHCCCCHHH	36.64	23684622
295	Phosphorylation	AIQEEETSSQGKAEN HHHHHHHCCCCHHHH	24.76	29550500
296	Phosphorylation	IQEEETSSQGKAENI HHHHHHCCCCHHHHH	50.82	23684622
306	Phosphorylation	KAENIMASLERSMHP HHHHHHHHHHHHCCH	17.24	21659605
431	Phosphorylation	VREMLWGTSTQLSND HHHHHHCCCEECCCC	19.61	22817900
432	Phosphorylation	REMLWGTSTQLSNDG HHHHHCCCEECCCCC	15.37	22817900
433	Phosphorylation	EMLWGTSTQLSNDGN HHHHCCCEECCCCCC	33.11	30635358
436	Phosphorylation	WGTSTQLSNDGNAKG HCCCEECCCCCCCCC	24.05	30635358
445	Phosphorylation	DGNAKGFSPESLIHG CCCCCCCCHHHHHHH	36.10	22817900
500	Phosphorylation	AEPYIKNSDPIKTAQ CCCCCCCCCHHHHHH	39.50	-
556	Phosphorylation	SPLYKQDSSKLSNED CCCCCCCCCCCCHHH	27.21	29514104
557	Phosphorylation	PLYKQDSSKLSNEDI CCCCCCCCCCCHHHH	46.00	29514104
571	Phosphorylation	ILKLLSEYKKPEKTK HHHHHHHCCCCCCCC	22.42	29514104
797	Phosphorylation	DAESRRQSNADIKWV CHHHHHHCCCCCEEC	31.97	25266776
919	Phosphorylation	LRSFIKYSFRPEKPS HHHHHHHHCCCCCCC	15.13	30482847
948	Phosphorylation	MIAILKQSADFLAIN HHHHHHHCCHHHHHH	28.37	20531401
1050	Phosphorylation	VFNLINDYISGFSPK HHHHHHHHHCCCCCC	7.78	24719451
1052	Phosphorylation	NLINDYISGFSPKDP HHHHHHHCCCCCCCH	27.79	24719451
1055	Phosphorylation	NDYISGFSPKDPKVL HHHHCCCCCCCHHHH	34.27	24719451
1186	Phosphorylation	QRLAGRDTLYSCAAM HHHCCCCCHHHHCCC	26.66	26239621
1188	Phosphorylation	LAGRDTLYSCAAMPS HCCCCCHHHHCCCCC	12.09	26239621
1208	Phosphorylation	EFPCGFVSPTNRGSL CCCCCCCCCCCCCCC	24.60	22942356
1210	Phosphorylation	PCGFVSPTNRGSLAS CCCCCCCCCCCCCCC	30.00	25338131
1221	Phosphorylation	SLASDKDTAYGSFQN CCCCCCCCCCCCCCC	27.76	25367039
1223	Phosphorylation	ASDKDTAYGSFQNGH CCCCCCCCCCCCCCC	18.52	22817900
1225	Phosphorylation	DKDTAYGSFQNGHGI CCCCCCCCCCCCCCC	15.81	23684622
1237	Phosphorylation	HGIKREDSRGSLIPE CCCCCCCCCCCCCCC	33.51	27087446
1240	Phosphorylation	KREDSRGSLIPEGAT CCCCCCCCCCCCCCC	23.24	25521595
1247	Phosphorylation	SLIPEGATGFPDPGS CCCCCCCCCCCCCCC	50.65	28833060
1254	Phosphorylation	TGFPDPGSTSENTRQ CCCCCCCCCCCCCCC	33.86	25338131
1256	Phosphorylation	FPDPGSTSENTRQSS CCCCCCCCCCCCCCC	30.46	28285833
1264	Phosphorylation	ENTRQSSSRSSVSQY CCCCCCCCCCCHHHH	41.24	23684622
1266	Phosphorylation	TRQSSSRSSVSQYNR CCCCCCCCCHHHHHC	36.72	23684622
1267	Phosphorylation	RQSSSRSSVSQYNRL CCCCCCCCHHHHHCC	25.36	25521595
1271	Phosphorylation	SRSSVSQYNRLDQYE CCCCHHHHHCCCHHH	8.51	-
1350	Phosphorylation	HFGIDRKSQTMPALR HHCCCCHHCCHHHHH	31.60	23527152
1352	Phosphorylation	GIDRKSQTMPALRNR CCCCHHCCHHHHHCC	32.01	23527152
1360	Phosphorylation	MPALRNRSGVMQARL HHHHHCCCCHHHHHH	39.01	29514104
1502	Phosphorylation	SSTRNEASALLYLLM CCCHHHHHHHHHHHH	17.17	28285833
1582	Phosphorylation	DLTKRIRTVLMATAQ HHHHHHHHHHHHHHH	18.67	27180971
1747	Phosphorylation	RTLHGAYTKILEVMH HHHHHHHHHHHHHHH	15.86	21183079
1755	Phosphorylation	KILEVMHTKKRLLGT HHHHHHHHHHHHHHH	21.84	22817900
2018	Phosphorylation	EYHEGLKSNFRDMVK HHHHHHHHHHHHHHH	46.36	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOC11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOC11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOC11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC42_MOUSE	Cdc42	physical	15710388

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1240, AND MASSSPECTROMETRY.
PubMed: 17242355