CBR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBR1_MOUSE
• UniProt AC: P48758
• Protein Name: Carbonyl reductase [NADPH] 1
• Gene Name: Cbr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm.
• Protein Description: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity)..
• Protein Sequence: MSSSRPVALVTGANKGIGFAITRDLCRKFSGDVVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRSETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSRPVAL ------CCCCCCEEE	36.70	26643407
2	Acetylation	------MSSSRPVAL ------CCCCCCEEE	36.70	-
3	Phosphorylation	-----MSSSRPVALV -----CCCCCCEEEE	29.12	26643407
4	Phosphorylation	----MSSSRPVALVT ----CCCCCCEEEEE	33.04	26643407
15	Ubiquitination	ALVTGANKGIGFAIT EEEECCCCCCCEECC	51.90	-
28	Ubiquitination	ITRDLCRKFSGDVVL CCHHHHHHCCCCEEE	42.77	-
28	Acetylation	ITRDLCRKFSGDVVL CCHHHHHHCCCCEEE	42.77	22826441
30	Phosphorylation	RDLCRKFSGDVVLAA HHHHHHCCCCEEEEE	36.80	26824392
49	Acetylation	RGQTAVQKLQAEGLS HHHHHHHHHHHCCCC	35.65	23954790
49	Ubiquitination	RGQTAVQKLQAEGLS HHHHHHHHHHHCCCC	35.65	-
49	Malonylation	RGQTAVQKLQAEGLS HHHHHHHHHHHCCCC	35.65	26320211
56	Phosphorylation	KLQAEGLSPRFHQLD HHHHCCCCCCCEECC	25.53	24759943
79	Acetylation	ALRDFLLKEYGGLDV HHHHHHHHHHCCCCE	51.54	23954790
122	S-palmitoylation	FFGTRDVCKELLPLI CCCHHHHHHHHHHHC	3.12	26165157
123	Ubiquitination	FGTRDVCKELLPLIK CCHHHHHHHHHHHCC	51.77	-
123	Malonylation	FGTRDVCKELLPLIK CCHHHHHHHHHHHCC	51.77	26320211
123	Acetylation	FGTRDVCKELLPLIK CCHHHHHHHHHHHCC	51.77	23864654
139	Phosphorylation	QGRVVNVSSMVSLRA CCCEEEEHHHHHHHH	13.91	29472430
140	Phosphorylation	GRVVNVSSMVSLRAL CCEEEEHHHHHHHHH	20.94	29472430
143	Phosphorylation	VNVSSMVSLRALKNC EEEHHHHHHHHHHCC	11.96	29472430
157	Ubiquitination	CRLELQQKFRSETIT CCHHHHHHHHHCCCC	29.77	-
157	Acetylation	CRLELQQKFRSETIT CCHHHHHHHHHCCCC	29.77	23806337
157	Malonylation	CRLELQQKFRSETIT CCHHHHHHHHHCCCC	29.77	26320211
157	Succinylation	CRLELQQKFRSETIT CCHHHHHHHHHCCCC	29.77	23806337
160	Phosphorylation	ELQQKFRSETITEEE HHHHHHHHCCCCHHH	42.07	22817900
162	Phosphorylation	QQKFRSETITEEELV HHHHHHCCCCHHHHH	34.15	22817900
164	Phosphorylation	KFRSETITEEELVGL HHHHCCCCHHHHHHH	44.77	21183079
174	Acetylation	ELVGLMNKFVEDTKK HHHHHHHHHHHHHHC	36.50	23954790
226	S-palmitoylation	DKILLNACCPGWVRT CEEEEECCCCCCCCC	2.54	28526873
227	S-palmitoylation	KILLNACCPGWVRTD EEEEECCCCCCCCCC	3.03	28526873
239	Malonylation	RTDMAGPKATKSPEE CCCCCCCCCCCCHHC	68.70	26320211
239	Carboxyethylation	RTDMAGPKATKSPEE CCCCCCCCCCCCHHC	68.70	-
241	Phosphorylation	DMAGPKATKSPEEGA CCCCCCCCCCHHCCC	37.88	29899451
243	Phosphorylation	AGPKATKSPEEGAET CCCCCCCCHHCCCCC	32.94	29899451
253	Phosphorylation	EGAETPVYLALLPPD CCCCCCEEEEECCCC	6.35	17242355
272	Ubiquitination	HGQFVQDKKVEPW-- CCCCCCCCCCCCC--	41.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CBR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.