| UniProt ID | LANC2_MOUSE | |
|---|---|---|
| UniProt AC | Q9JJK2 | |
| Protein Name | LanC-like protein 2 | |
| Gene Name | Lancl2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 450 | |
| Subcellular Localization | Nucleus . Cytoplasm . Cell membrane . Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhan | |
| Protein Description | Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.. | |
| Protein Sequence | MGETMSKRLKFHLGEAEMEERSFPNPFPDYEAAASAAGLAAGSAEETGRVCPLPTTEDPGLPFHPNGKIVPNFIKRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAVIYHKLKSECESQECITKLLQMHRTIVCQESELPDELLYGRAGYLYALLYLNTEIGPGTVGETAIKEVVSAIIESGKSLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPEAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHVLLQAYQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTSGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDILVPETARFPAFELGFLQKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGETMSKRL ------CCCCHHHHH | 38.80 | - | |
| 75 | Ubiquitination | KIVPNFIKRIQTKIK CCCHHHHHHHHHHHH | 39.03 | 22790023 | |
| 82 | Ubiquitination | KRIQTKIKDLLQQME HHHHHHHHHHHHHHH | 43.83 | 22790023 | |
| 149 | S-palmitoylation | GRRVTFLCGDAGPLA CCEEEEECCCCCHHH | 3.96 | 28680068 | |
| 166 | Ubiquitination | AVIYHKLKSECESQE HHHHHHHHHHHHCHH | 49.35 | 22790023 | |
| 177 | Ubiquitination | ESQECITKLLQMHRT HCHHHHHHHHHHHCC | 27.56 | 22790023 | |
| 187 | S-nitrosylation | QMHRTIVCQESELPD HHHCCEECCCCCCCC | 3.08 | 24895380 | |
| 198 | Phosphorylation | ELPDELLYGRAGYLY CCCCHHHHCHHHHHH | 19.72 | 22817900 | |
| 229 | Phosphorylation | TAIKEVVSAIIESGK HHHHHHHHHHHHHCC | 20.94 | 27180971 | |
| 234 | Phosphorylation | VVSAIIESGKSLSRE HHHHHHHHCCCCCHH | 40.90 | 27180971 | |
| 259 | Phosphorylation | YQWHRKQYVGAAHGM HHHHHHHHHHHHHHH | 12.13 | 22817900 | |
| 290 | Ubiquitination | ETLTEMVKPSIDYVR HHHHHHHCCCCCHHH | 31.56 | 22790023 | |
| 292 | Phosphorylation | LTEMVKPSIDYVRHK HHHHHCCCCCHHHCC | 23.52 | 20415495 | |
| 295 | Phosphorylation | MVKPSIDYVRHKKFR HHCCCCCHHHCCCCC | 9.56 | 29899451 | |
| 314 | Phosphorylation | PSSLSNETDRLVHWC CCCCCCHHHHHHHHH | 30.57 | 29899451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LANC2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LANC2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LANC2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LANC2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-198; TYR-259 ANDTYR-295, AND MASS SPECTROMETRY. | |
