RIMS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIMS2_MOUSE
• UniProt AC: Q9EQZ7
• Protein Name: Regulating synaptic membrane exocytosis protein 2
• Gene Name: Rims2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1530
• Subcellular Localization: Cell junction, synapse, synaptosome.
• Protein Description: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity)..
• Protein Sequence: MSAPLGPRGRPAPTPAASQPPPQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKIKEEHKAQPTQWFPFSGITELVNNVLQPQQKQPNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTLQQPDQKVPRGLRNEEAPQEKKAKLHEQPQFQGAPGDLSVPAVEKGRAHGLTRQDTIKNGSGVKHQIASDMPSDRKRSPSVSRDQNRRYEQSEEREDYSQYVPSDGTMPRSPSDYADRRSQREPQFYEEPGHLNYRDSNRRGHRHSKEYIVDDEDVESRDEYERQRREEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANAELEDSRISLLRMDRPSRQRSVSERRAAMENQRSYSMERTREAQGQSSYPQRTSNHSPPTPRRSPIPLDRPDMRRADSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPRPHKSKKGGKMRQVSLSSSEEELASTPEYTSCDDVELESESVSEKGDSQKGKRKTSEQGVLSDSNTRSERQKKRMYYGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPRPSPYLPRRQLHGESPTRRLQRSKRISDSEVSDYDCEDGVGVVSDYRHNGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSAPPPQRNVEQGHRGTRATGHYNTISRMDRHRVMDDHYSSDRDRSHPRTGSVQTSPSSTPGTGRRGRQLPQLPPKGTLERSAMDIEERNRQMKLNKYKQVAGSDPRLEQDYHSKYRSGWDPHRGADTVSTKSSDSDVSDVSAVSRTSSASRFSSTSYMSVQSERPRGNRKISVFTSKMQNRQMGVSGKNLTKSTSISGDMCSLEKNDGSQSDTAVGALGTSGKKRRSSIGAKMVAIVGLSRKSRSASQLSQTEGGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGRVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15 (in isoform 2)	Phosphorylation	-	25.44	-
19 (in isoform 2)	Phosphorylation	-	50.20	-
278	Phosphorylation	SDRKRSPSVSRDQNR CCCCCCCCCCHHHHH	33.69	29899451
287	Phosphorylation	SRDQNRRYEQSEERE CHHHHHHHCCHHHHH	18.32	29899451
309	Phosphorylation	SDGTMPRSPSDYADR CCCCCCCCHHHHCHH	23.92	19060867
311	Phosphorylation	GTMPRSPSDYADRRS CCCCCCHHHHCHHHH	44.49	20415495
313	Phosphorylation	MPRSPSDYADRRSQR CCCCHHHHCHHHHHC	18.10	29899451
333	Phosphorylation	EEPGHLNYRDSNRRG CCCCCCCCCCCCCCC	23.35	29899451
336	Phosphorylation	GHLNYRDSNRRGHRH CCCCCCCCCCCCCCC	24.20	29899451
356	Phosphorylation	VDDEDVESRDEYERQ CCCCCCCCHHHHHHH	44.90	29899451
373	Phosphorylation	EEEYQARYRSDPNLA HHHHHHHHCCCCCCC	19.93	23527152
375	Phosphorylation	EYQARYRSDPNLARY HHHHHHCCCCCCCCC	48.78	22324799
409	Phosphorylation	ARHERRHSDVSLANA HHHHHHHCCCCCCCC	37.59	25521595
412	Phosphorylation	ERRHSDVSLANAELE HHHHCCCCCCCCCCC	27.10	22324799
436	Phosphorylation	DRPSRQRSVSERRAA CCHHHHCCHHHHHHH	22.96	-
449	Phosphorylation	AAMENQRSYSMERTR HHHHHHHHHHHHHHH	16.28	23527152
450	Phosphorylation	AMENQRSYSMERTRE HHHHHHHHHHHHHHH	17.77	29899451
451	Phosphorylation	MENQRSYSMERTREA HHHHHHHHHHHHHHH	18.53	23527152
468	Phosphorylation	QSSYPQRTSNHSPPT CCCCCCCCCCCCCCC	28.74	22871156
469	Phosphorylation	SSYPQRTSNHSPPTP CCCCCCCCCCCCCCC	34.43	16452087
472	Phosphorylation	PQRTSNHSPPTPRRS CCCCCCCCCCCCCCC	36.50	21454597
475	Phosphorylation	TSNHSPPTPRRSPIP CCCCCCCCCCCCCCC	32.58	28066266
479	Phosphorylation	SPPTPRRSPIPLDRP CCCCCCCCCCCCCCC	28.58	27180971
493	Phosphorylation	PDMRRADSLRKQHHL CCHHHHHHHHHHHCC	29.14	26824392
503	Phosphorylation	KQHHLDPSSAVRKTK HHHCCCHHHHHHHHH	30.51	21183079
504	Phosphorylation	QHHLDPSSAVRKTKR HHCCCHHHHHHHHHH	35.85	21183079
522	Phosphorylation	ETMLRNDSLSSDQSE HHHHHCCCCCCCCCC	33.43	21183079
524	Phosphorylation	MLRNDSLSSDQSESV HHHCCCCCCCCCCCC	35.50	21183079
525	Phosphorylation	LRNDSLSSDQSESVR HHCCCCCCCCCCCCC	44.99	21183079
530	Phosphorylation	LSSDQSESVRPPPPR CCCCCCCCCCCCCCC	28.77	25266776
541	Phosphorylation	PPPRPHKSKKGGKMR CCCCCCCCCCCCEEE	36.24	-
598	Phosphorylation	TSEQGVLSDSNTRSE CCCCCCCCCCCCCCH	36.26	27841257
617	Phosphorylation	RMYYGGHSLEEDLEW HHHHCCCCHHHCCCC	40.53	29899451
679	Phosphorylation	NKRLKDGSVPRDSGA CCCCCCCCCCCCCCC	38.80	28066266
698	Phosphorylation	KVVGGKMTESGRLCA EEECCEECCCCCEEE	30.41	-
783	Phosphorylation	HAQLESSSSSFESQK CHHHHCCCHHHHCCC	39.00	20415495
784	Phosphorylation	AQLESSSSSFESQKM HHHHCCCHHHHCCCC	40.78	29899451
785	Phosphorylation	QLESSSSSFESQKMD HHHCCCHHHHCCCCC	34.67	20415495
788	Phosphorylation	SSSSSFESQKMDRPS CCCHHHHCCCCCCCC	32.84	29899451
799	Phosphorylation	DRPSISVTSPMSPGM CCCCCEECCCCCCCH	21.96	25367039
800	Phosphorylation	RPSISVTSPMSPGML CCCCEECCCCCCCHH	19.22	25521595
803	Phosphorylation	ISVTSPMSPGMLRDV CEECCCCCCCHHCCC	22.99	25521595
855	Ubiquitination	RPRNPYVKIYFLPDR CCCCCCEEEEECCCC	26.33	-
863	Phosphorylation	IYFLPDRSDKNKRRT EEECCCCCCCCCCCC	61.39	-
941	Phosphorylation	PHWYKLQTHDVSSLP CCEEEEEECCCCCCC	30.40	28418008
945	Phosphorylation	KLQTHDVSSLPLPRP EEEECCCCCCCCCCC	32.01	28418008
953	Phosphorylation	SLPLPRPSPYLPRRQ CCCCCCCCCCCCHHH	27.70	26824392
955	Phosphorylation	PLPRPSPYLPRRQLH CCCCCCCCCCHHHHC	33.41	29899451
965	Phosphorylation	RRQLHGESPTRRLQR HHHHCCCCHHHHHHH	35.84	25521595
967	Phosphorylation	QLHGESPTRRLQRSK HHCCCCHHHHHHHHC	37.39	22324799
977	Phosphorylation	LQRSKRISDSEVSDY HHHHCCCCCCCCCCC	38.83	28066266
979	Phosphorylation	RSKRISDSEVSDYDC HHCCCCCCCCCCCCC	32.86	21183079
982	Phosphorylation	RISDSEVSDYDCEDG CCCCCCCCCCCCCCC	26.80	28066266
984	Phosphorylation	SDSEVSDYDCEDGVG CCCCCCCCCCCCCCE	18.26	28066266
1021	Phosphorylation	VMSSNHCSPSGSPHR HHHCCCCCCCCCCCE	17.98	27717184
1023	Phosphorylation	SSNHCSPSGSPHRVD HCCCCCCCCCCCEEE	35.29	27717184
1025	Phosphorylation	NHCSPSGSPHRVDVI CCCCCCCCCCEEEEC	23.13	27717184
1035	Phosphorylation	RVDVIGRTRSWSPSA EEEECCCCCCCCCCC	24.68	28066266
1037	Phosphorylation	DVIGRTRSWSPSAPP EECCCCCCCCCCCCC	31.15	28066266
1039	Phosphorylation	IGRTRSWSPSAPPPQ CCCCCCCCCCCCCCC	15.38	28066266
1041	Phosphorylation	RTRSWSPSAPPPQRN CCCCCCCCCCCCCCC	48.14	28066266
1089	Phosphorylation	RDRSHPRTGSVQTSP CCCCCCCCCCCCCCC	37.96	25521595
1091	Phosphorylation	RSHPRTGSVQTSPSS CCCCCCCCCCCCCCC	15.50	19060867
1094	Phosphorylation	PRTGSVQTSPSSTPG CCCCCCCCCCCCCCC	40.21	25521595
1095	Phosphorylation	RTGSVQTSPSSTPGT CCCCCCCCCCCCCCC	12.99	25521595
1097	Phosphorylation	GSVQTSPSSTPGTGR CCCCCCCCCCCCCCC	46.76	25521595
1098	Phosphorylation	SVQTSPSSTPGTGRR CCCCCCCCCCCCCCC	41.84	28066266
1099	Phosphorylation	VQTSPSSTPGTGRRG CCCCCCCCCCCCCCC	30.03	28066266
1102	Phosphorylation	SPSSTPGTGRRGRQL CCCCCCCCCCCCCCC	28.81	29899451
1143	Phosphorylation	KYKQVAGSDPRLEQD HHHHHCCCCCCHHHH	34.40	24719451
1169	Phosphorylation	HRGADTVSTKSSDSD CCCCCCCCCCCCCCC	32.01	21082442
1170	Phosphorylation	RGADTVSTKSSDSDV CCCCCCCCCCCCCCH	30.52	27841257
1172	Phosphorylation	ADTVSTKSSDSDVSD CCCCCCCCCCCCHHH	39.19	27841257
1173	Phosphorylation	DTVSTKSSDSDVSDV CCCCCCCCCCCHHHH	42.56	25521595
1175	Phosphorylation	VSTKSSDSDVSDVSA CCCCCCCCCHHHHHH	41.69	19060867
1215	Phosphorylation	NRKISVFTSKMQNRQ CCEEEEEEHHHCCCC	25.86	25159016
1216	Phosphorylation	RKISVFTSKMQNRQM CEEEEEEHHHCCCCC	18.05	25159016
1226	Phosphorylation	QNRQMGVSGKNLTKS CCCCCCCCCCCCCCC	38.02	25159016
1233	Phosphorylation	SGKNLTKSTSISGDM CCCCCCCCCCCCCCC	23.35	28066266
1234	Phosphorylation	GKNLTKSTSISGDMC CCCCCCCCCCCCCCC	31.47	28066266
1235	Phosphorylation	KNLTKSTSISGDMCS CCCCCCCCCCCCCCE	23.11	28066266
1237	Phosphorylation	LTKSTSISGDMCSLE CCCCCCCCCCCCEEE	28.62	28066266
1249	Phosphorylation	SLEKNDGSQSDTAVG EEECCCCCCCCCCHH	29.40	24759943
1251	Phosphorylation	EKNDGSQSDTAVGAL ECCCCCCCCCCHHHC	38.33	25521595
1253	Phosphorylation	NDGSQSDTAVGALGT CCCCCCCCCHHHCCC	28.61	20415495
1261	Phosphorylation	AVGALGTSGKKRRSS CHHHCCCCCCCCHHC	46.98	27841257
1268	Phosphorylation	SGKKRRSSIGAKMVA CCCCCHHCHHHHHHH	24.19	29899451
1280	Phosphorylation	MVAIVGLSRKSRSAS HHHHHCCCCCCCCHH	31.56	-
1283	Phosphorylation	IVGLSRKSRSASQLS HHCCCCCCCCHHHHH	30.29	29899451
1285	Phosphorylation	GLSRKSRSASQLSQT CCCCCCCCHHHHHCC	39.09	25521595
1287	Phosphorylation	SRKSRSASQLSQTEG CCCCCCHHHHHCCCC	32.66	21183079
1292	Phosphorylation	SASQLSQTEGGGKKL CHHHHHCCCCCHHHH	32.97	29899451
1306	Phosphorylation	LRSTVQRSTETGLAV HHHHHHHHHHCCCHH	17.32	21183079
1307	Phosphorylation	RSTVQRSTETGLAVE HHHHHHHHHCCCHHH	39.49	21183079
1324	Phosphorylation	NWMTRQASRESTDGS HHHHHHHHHCCCCCC	28.39	25521595
1327	Phosphorylation	TRQASRESTDGSMNS HHHHHHCCCCCCCCC	30.59	29899451
1328	Phosphorylation	RQASRESTDGSMNSY HHHHHCCCCCCCCCC	39.36	29899451
1331	Phosphorylation	SRESTDGSMNSYSSE HHCCCCCCCCCCCCC	20.01	29899451
1337	Phosphorylation	GSMNSYSSEGNLIFP CCCCCCCCCCCEECC	41.09	29899451
1350	Phosphorylation	FPGVRLASDSQFSDF CCCCEECCCCCHHHH	42.24	29899451
1352	Phosphorylation	GVRLASDSQFSDFLD CCEECCCCCHHHHHC	30.54	29899451
1355	Phosphorylation	LASDSQFSDFLDGLG ECCCCCHHHHHCCCC	21.59	29899451
1472	Phosphorylation	YGRMDHKSFMGVAQI CCCCCHHHHHHHHHH	19.62	-
1515	Phosphorylation	APLTRRASQSSLESS HHHHHHHHHHHHHCC	28.87	25521595
1517	Phosphorylation	LTRRASQSSLESSTG HHHHHHHHHHHCCCC	34.10	18388127
1518	Phosphorylation	TRRASQSSLESSTGP HHHHHHHHHHCCCCC	28.63	25521595
1521	Phosphorylation	ASQSSLESSTGPSYS HHHHHHHCCCCCCCC	38.19	28066266
1522	Phosphorylation	SQSSLESSTGPSYSR HHHHHHCCCCCCCCC	28.18	28066266
1527	Phosphorylation	ESSTGPSYSRS---- HCCCCCCCCCC----	15.96	29899451
1528	O-linked_Glycosylation	SSTGPSYSRS----- CCCCCCCCCC-----	30.31	22517741
1528	Phosphorylation	SSTGPSYSRS----- CCCCCCCCCC-----	30.31	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIMS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIMS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIMS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB3A_MOUSE	Rab3a	physical	11056535
RPGF4_MOUSE	Rapgef4	physical	11056535
RAB3A_MOUSE	Rab3a	physical	12578829
RAB3B_MOUSE	Rab3b	physical	12578829
RAB3C_MOUSE	Rab3c	physical	12578829
RAB3D_MOUSE	Rab3d	physical	12578829
RAB8A_MOUSE	Rab8a	physical	12578829

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039 AND THR-1094, ANDMASS SPECTROMETRY.
PubMed: 17114649

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375 AND SER-409, ANDMASS SPECTROMETRY.
PubMed: 16452087