RPGF4_MOUSE - dbPTM
RPGF4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPGF4_MOUSE
UniProt AC Q9EQZ6
Protein Name Rap guanine nucleotide exchange factor 4
Gene Name Rapgef4
Organism Mus musculus (Mouse).
Sequence Length 1011
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein.
Protein Description Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2..
Protein Sequence MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
153 (in isoform 3)Phosphorylation-4.6729895711
167 (in isoform 3)Phosphorylation-28.0229895711
169 (in isoform 3)Phosphorylation-39.6229895711
182 (in isoform 3)Phosphorylation-6.9729895711
184 (in isoform 3)Ubiquitination-36.72-
202UbiquitinationITKVPSEKILRAGKI
EEECCCHHHHHHCCH
51.91-
208AcetylationEKILRAGKILRIAIL
HHHHHHCCHHHHHHH
37.2722902405
283UbiquitinationQERHFQDKYLFYRFL
CHHHCCCCCHHHCCC
32.82-
320PhosphorylationQDTMLLLSQMGPDAH
HHHHHHHHHHCCCHH
20.3529233185
348PhosphorylationVDDLEIIYDELLHIK
CCHHHHHHHHHHHHH
14.7122817900
358PhosphorylationLLHIKALSHLSTTVK
HHHHHHHHCCCHHHH
27.5225367039
361PhosphorylationIKALSHLSTTVKREL
HHHHHCCCHHHHHHH
19.3325367039
362PhosphorylationKALSHLSTTVKRELA
HHHHCCCHHHHHHHC
41.8025367039
363PhosphorylationALSHLSTTVKRELAG
HHHCCCHHHHHHHCC
22.2125367039
376PhosphorylationAGVLIFESHAKGGTV
CCEEEEEECCCCCEE
20.2825367039
631UbiquitinationPELEKIVKQISEDAK
HHHHHHHHHHHHHCC
45.44-
645UbiquitinationKAPQKKHKVLLQQFN
CCCHHHHHHHHHHCC
43.38-
653PhosphorylationVLLQQFNTGDERAQK
HHHHHCCCCCHHHHH
47.5022817900
680PhosphorylationKVYCIDHTYTTIRVP
EEEEEECCEEEEECC
20.8622817900
681PhosphorylationVYCIDHTYTTIRVPV
EEEEECCEEEEECCC
9.8522817900
682PhosphorylationYCIDHTYTTIRVPVA
EEEECCEEEEECCCC
19.5322817900
683PhosphorylationCIDHTYTTIRVPVAA
EEECCEEEEECCCCC
9.0722817900
693UbiquitinationVPVAASVKEVISAVA
CCCCCCHHHHHHHHH
43.71-
857PhosphorylationIAAHCKEYKNLNSFF
HHHHHHHCCCHHHHH
7.23-
915UbiquitinationAYRLTAAKLEPPLIP
HHHHHHHHCCCCCCC
51.42-
950UbiquitinationDNLVNFEKMRMIANT
HHHCCHHHHHHHHHH
27.89-
978UbiquitinationPDAAQANKNHQDVRS
CCHHHHCCCHHHHHH
59.84-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPGF4_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPGF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPGF4_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RPGF4_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPGF4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-681, AND MASSSPECTROMETRY.

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