UniProt ID | RPGF4_MOUSE | |
---|---|---|
UniProt AC | Q9EQZ6 | |
Protein Name | Rap guanine nucleotide exchange factor 4 | |
Gene Name | Rapgef4 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1011 | |
Subcellular Localization |
Cytoplasm. Membrane Peripheral membrane protein. |
|
Protein Description | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.. | |
Protein Sequence | MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
153 (in isoform 3) | Phosphorylation | - | 4.67 | 29895711 | |
167 (in isoform 3) | Phosphorylation | - | 28.02 | 29895711 | |
169 (in isoform 3) | Phosphorylation | - | 39.62 | 29895711 | |
182 (in isoform 3) | Phosphorylation | - | 6.97 | 29895711 | |
184 (in isoform 3) | Ubiquitination | - | 36.72 | - | |
202 | Ubiquitination | ITKVPSEKILRAGKI EEECCCHHHHHHCCH | 51.91 | - | |
208 | Acetylation | EKILRAGKILRIAIL HHHHHHCCHHHHHHH | 37.27 | 22902405 | |
283 | Ubiquitination | QERHFQDKYLFYRFL CHHHCCCCCHHHCCC | 32.82 | - | |
320 | Phosphorylation | QDTMLLLSQMGPDAH HHHHHHHHHHCCCHH | 20.35 | 29233185 | |
348 | Phosphorylation | VDDLEIIYDELLHIK CCHHHHHHHHHHHHH | 14.71 | 22817900 | |
358 | Phosphorylation | LLHIKALSHLSTTVK HHHHHHHHCCCHHHH | 27.52 | 25367039 | |
361 | Phosphorylation | IKALSHLSTTVKREL HHHHHCCCHHHHHHH | 19.33 | 25367039 | |
362 | Phosphorylation | KALSHLSTTVKRELA HHHHCCCHHHHHHHC | 41.80 | 25367039 | |
363 | Phosphorylation | ALSHLSTTVKRELAG HHHCCCHHHHHHHCC | 22.21 | 25367039 | |
376 | Phosphorylation | AGVLIFESHAKGGTV CCEEEEEECCCCCEE | 20.28 | 25367039 | |
631 | Ubiquitination | PELEKIVKQISEDAK HHHHHHHHHHHHHCC | 45.44 | - | |
645 | Ubiquitination | KAPQKKHKVLLQQFN CCCHHHHHHHHHHCC | 43.38 | - | |
653 | Phosphorylation | VLLQQFNTGDERAQK HHHHHCCCCCHHHHH | 47.50 | 22817900 | |
680 | Phosphorylation | KVYCIDHTYTTIRVP EEEEEECCEEEEECC | 20.86 | 22817900 | |
681 | Phosphorylation | VYCIDHTYTTIRVPV EEEEECCEEEEECCC | 9.85 | 22817900 | |
682 | Phosphorylation | YCIDHTYTTIRVPVA EEEECCEEEEECCCC | 19.53 | 22817900 | |
683 | Phosphorylation | CIDHTYTTIRVPVAA EEECCEEEEECCCCC | 9.07 | 22817900 | |
693 | Ubiquitination | VPVAASVKEVISAVA CCCCCCHHHHHHHHH | 43.71 | - | |
857 | Phosphorylation | IAAHCKEYKNLNSFF HHHHHHHCCCHHHHH | 7.23 | - | |
915 | Ubiquitination | AYRLTAAKLEPPLIP HHHHHHHHCCCCCCC | 51.42 | - | |
950 | Ubiquitination | DNLVNFEKMRMIANT HHHCCHHHHHHHHHH | 27.89 | - | |
978 | Ubiquitination | PDAAQANKNHQDVRS CCHHHHCCCHHHHHH | 59.84 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPGF4_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPGF4_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPGF4_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of RPGF4_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-681, AND MASSSPECTROMETRY. |