dbPTM

RAB3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB3B_MOUSE
UniProt AC	Q9CZT8
Protein Name	Ras-related protein Rab-3B
Gene Name	Rab3b
Organism	Mus musculus (Mouse).
Sequence Length	219
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Golgi apparatus . Colocalizes with GAS8/DRC4 in the Golgi apparatus.
Protein Description	Protein transport. Probably involved in vesicular traffic (By similarity)..
Protein Sequence	MASVTDGKTGIKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCSC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASVTDGKT ------CCCCCCCCC	16.83	-
3	Phosphorylation	-----MASVTDGKTG -----CCCCCCCCCC	25.01	20495213
5	Phosphorylation	---MASVTDGKTGIK ---CCCCCCCCCCCC	36.22	20495213
31	Phosphorylation	KLLIIGNSSVGKTSF EEEEECCCCCCCEEE	22.61	22817900
32	Phosphorylation	LLIIGNSSVGKTSFL EEEECCCCCCCEEEE	38.60	22817900
37	Phosphorylation	NSSVGKTSFLFRYAD CCCCCCEEEEEEECC	24.36	-
86	Phosphorylation	AGQERYRTITTAYYR CCHHHHHHHHHHHHH	17.46	29125462
91	Phosphorylation	YRTITTAYYRGAMGF HHHHHHHHHHCCCEE	7.51	29514104
188	Phosphorylation	DAICDKMSDSMDTDP HHHHHHCCCCCCCCH	32.07	25521595
190	Phosphorylation	ICDKMSDSMDTDPSV HHHHCCCCCCCCHHH	15.96	27087446
193	Phosphorylation	KMSDSMDTDPSVLGA HCCCCCCCCHHHHCC	40.96	25521595
202	Ubiquitination	PSVLGASKTTRLSDT HHHHCCCCCCCCCCC	54.07	-
217	Geranylgeranylation	PPLLQQNCSC----- CCHHHCCCCC-----	3.69	-
219	Methylation	LLQQNCSC------- HHHCCCCC-------	7.62	-
219	Geranylgeranylation	LLQQNCSC------- HHHCCCCC-------	7.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
86	T	Phosphorylation	Kinase	LRRK2	Q5S006	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
86	T	Phosphorylation		29125462
Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB3B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RAB3B_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB3B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, AND MASSSPECTROMETRY.	17114649 [Abstract]