DCLK1_MOUSE - dbPTM
DCLK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCLK1_MOUSE
UniProt AC Q9JLM8
Protein Name Serine/threonine-protein kinase DCLK1
Gene Name Dclk1
Organism Mus musculus (Mouse).
Sequence Length 756
Subcellular Localization
Protein Description Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity)..
Protein Sequence MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGGPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASASRRGTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTSLSSTKVCSSMDENDGPGEGDELGRRHSLQRGWRREESEEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFGRDMEL
------CCCCCCCCC
36.0926824392
22PhosphorylationRDKAQRYSRGSRVNG
HHHHHHHCCCCCCCC
32.1422871156
25PhosphorylationAQRYSRGSRVNGLPS
HHHHCCCCCCCCCCC
31.7626160508
32PhosphorylationSRVNGLPSPTHSAHC
CCCCCCCCCCCCCCC
47.6918388127
34PhosphorylationVNGLPSPTHSAHCSF
CCCCCCCCCCCCCHH
32.5726824392
36PhosphorylationGLPSPTHSAHCSFYR
CCCCCCCCCCCHHHH
23.3718388127
40PhosphorylationPTHSAHCSFYRTRTL
CCCCCCCHHHHHCCH
18.5526160508
42PhosphorylationHSAHCSFYRTRTLQT
CCCCCHHHHHCCHHH
8.5226160508
44PhosphorylationAHCSFYRTRTLQTLS
CCCHHHHHCCHHHHC
19.3429899451
46PhosphorylationCSFYRTRTLQTLSSE
CHHHHHCCHHHHCCC
23.7024899341
49PhosphorylationYRTRTLQTLSSEKKA
HHHCCHHHHCCCCCC
31.5529899451
51PhosphorylationTRTLQTLSSEKKAKK
HCCHHHHCCCCCCCE
39.5827149854
68PhosphorylationFYRNGDRYFKGIVYA
EEECCCCCCEEEEEE
17.87-
74PhosphorylationRYFKGIVYAISPDRF
CCCEEEEEEECHHHH
9.0428066266
77PhosphorylationKGIVYAISPDRFRSF
EEEEEEECHHHHHCH
16.7521082442
118PhosphorylationIDGLKKISSLDQLVE
ECHHHHHCCHHHHHC
33.4622807455
119PhosphorylationDGLKKISSLDQLVEG
CHHHHHCCHHHHHCC
39.1619060867
164PhosphorylationTSASRAVSSLATAKG
CCHHHHHHHHHHCCC
20.7426824392
193PhosphorylationKLVTIIRSGVKPRKA
HHHHHHHCCCCHHHH
37.2127149854
209PhosphorylationRILLNKKTAHSFEQV
HHHCCCCCCCCHHHH
31.0825177544
212PhosphorylationLNKKTAHSFEQVLTD
CCCCCCCCHHHHHHH
28.1919060867
283PhosphorylationCRVVKSTSYTKIASA
CEEEECCCCEEEEEC
37.5927149854
284PhosphorylationRVVKSTSYTKIASAS
EEEECCCCEEEEECC
16.4921454597
295PhosphorylationASASRRGTTKSPGPS
EECCCCCCCCCCCCC
29.2829899451
296PhosphorylationSASRRGTTKSPGPSR
ECCCCCCCCCCCCCC
32.1424453211
298PhosphorylationSRRGTTKSPGPSRRS
CCCCCCCCCCCCCCC
32.7526824392
302PhosphorylationTTKSPGPSRRSKSPA
CCCCCCCCCCCCCCC
46.3623375375
305PhosphorylationSPGPSRRSKSPASTS
CCCCCCCCCCCCCCC
36.0525521595
307PhosphorylationGPSRRSKSPASTSSV
CCCCCCCCCCCCCCC
27.2625521595
310PhosphorylationRRSKSPASTSSVNGT
CCCCCCCCCCCCCCC
32.0021082442
311PhosphorylationRSKSPASTSSVNGTP
CCCCCCCCCCCCCCC
27.4225177544
312PhosphorylationSKSPASTSSVNGTPG
CCCCCCCCCCCCCCC
29.7821082442
313PhosphorylationKSPASTSSVNGTPGS
CCCCCCCCCCCCCCC
21.4925177544
317PhosphorylationSTSSVNGTPGSQLST
CCCCCCCCCCCCCCC
21.1925619855
320PhosphorylationSVNGTPGSQLSTPRS
CCCCCCCCCCCCCCC
29.2025619855
323PhosphorylationGTPGSQLSTPRSGKS
CCCCCCCCCCCCCCC
28.8225619855
324PhosphorylationTPGSQLSTPRSGKSP
CCCCCCCCCCCCCCC
31.1725619855
327PhosphorylationSQLSTPRSGKSPSPS
CCCCCCCCCCCCCCC
52.3421082442
330PhosphorylationSTPRSGKSPSPSPTS
CCCCCCCCCCCCCCC
33.8525521595
332 (in isoform 2)Phosphorylation-45.1328285833
332PhosphorylationPRSGKSPSPSPTSPG
CCCCCCCCCCCCCCC
45.1325521595
334PhosphorylationSGKSPSPSPTSPGSL
CCCCCCCCCCCCCCC
45.1825521595
336 (in isoform 2)Phosphorylation-52.4725521595
336PhosphorylationKSPSPSPTSPGSLRK
CCCCCCCCCCCCCCH
52.4718388127
337 (in isoform 2)Phosphorylation-30.5525521595
337PhosphorylationSPSPSPTSPGSLRKQ
CCCCCCCCCCCCCHH
30.5525521595
340 (in isoform 2)Phosphorylation-28.5229899451
340PhosphorylationPSPTSPGSLRKQRIS
CCCCCCCCCCHHHHH
28.5225521595
347PhosphorylationSLRKQRISQHGGSST
CCCHHHHHHCCCCCC
20.5021082442
348 (in isoform 2)Phosphorylation-36.5527180971
352PhosphorylationRISQHGGSSTSLSST
HHHHCCCCCCCCCCC
34.7318388127
352 (in isoform 2)Phosphorylation-34.7325177544
353 (in isoform 2)Phosphorylation-25.8725177544
353PhosphorylationISQHGGSSTSLSSTK
HHHCCCCCCCCCCCC
25.8725177544
354PhosphorylationSQHGGSSTSLSSTKV
HHCCCCCCCCCCCCE
35.0725177544
355PhosphorylationQHGGSSTSLSSTKVC
HCCCCCCCCCCCCEE
28.3518388127
357PhosphorylationGGSSTSLSSTKVCSS
CCCCCCCCCCCEECC
35.4121082442
358PhosphorylationGSSTSLSSTKVCSSM
CCCCCCCCCCEECCC
37.2226824392
358 (in isoform 2)Phosphorylation-37.2227149854
359PhosphorylationSSTSLSSTKVCSSMD
CCCCCCCCCEECCCC
24.9129233185
362 (in isoform 2)Phosphorylation-2.3826824392
363PhosphorylationLSSTKVCSSMDENDG
CCCCCEECCCCCCCC
31.5222324799
364PhosphorylationSSTKVCSSMDENDGP
CCCCEECCCCCCCCC
25.7325521595
382PhosphorylationDELGRRHSLQRGWRR
CHHHHHHHHHCCCCH
25.1222324799
392PhosphorylationRGWRREESEEGFQIP
CCCCHHHCCCCCCCC
35.8725521595
421UbiquitinationDGNFAVVKECIERST
CCCCHHHHHHHHHHH
40.02-
498UbiquitinationDAITSTSKYTERDAS
HHHCCCCCCCCCCHH
57.17-
509PhosphorylationRDASGMLYNLASAIK
CCHHHHHHHHHHHHH
10.1522817900
529UbiquitinationNIVHRDIKPENLLVY
CCCCCCCCHHHEEEE
51.04-
536PhosphorylationKPENLLVYEHQDGSK
CHHHEEEEEECCCCC
13.9922817900
703PhosphorylationAGVSVIATTALDKER
HCCEEEEECCCHHHH
11.0722807455
736PhosphorylationPAPPELNSESEDYSP
CCCCCCCCCCCCCCC
55.9418388127
738PhosphorylationPPELNSESEDYSPSS
CCCCCCCCCCCCCCC
35.2725521595
741PhosphorylationLNSESEDYSPSSSET
CCCCCCCCCCCCCCC
20.5923527152
742PhosphorylationNSESEDYSPSSSETV
CCCCCCCCCCCCCCC
30.5425521595
744PhosphorylationESEDYSPSSSETVRS
CCCCCCCCCCCCCCC
40.3225521595
745PhosphorylationSEDYSPSSSETVRSP
CCCCCCCCCCCCCCC
35.2621183079
746PhosphorylationEDYSPSSSETVRSPN
CCCCCCCCCCCCCCC
41.4422807455
748PhosphorylationYSPSSSETVRSPNSP
CCCCCCCCCCCCCCC
24.1422817900
751PhosphorylationSSSETVRSPNSPF--
CCCCCCCCCCCCC--
24.8919060867
754PhosphorylationETVRSPNSPF-----
CCCCCCCCCC-----
30.9425521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
382SPhosphorylationKinaseDCLK1Q9JLM8
PhosphoELM

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCLK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCLK1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCLK1_MOUSEDclk1physical
16387639

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCLK1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-332 ANDSER-337, AND MASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 AND SER-36, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-332 ANDTHR-336, AND MASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-392, ANDMASS SPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307; SER-738AND SER-742, AND MASS SPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-509 AND TYR-536, ANDMASS SPECTROMETRY.

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