UniProt ID | DCLK1_MOUSE | |
---|---|---|
UniProt AC | Q9JLM8 | |
Protein Name | Serine/threonine-protein kinase DCLK1 | |
Gene Name | Dclk1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 756 | |
Subcellular Localization | ||
Protein Description | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).. | |
Protein Sequence | MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGGPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASASRRGTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTSLSSTKVCSSMDENDGPGEGDELGRRHSLQRGWRREESEEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MSFGRDMEL ------CCCCCCCCC | 36.09 | 26824392 | |
22 | Phosphorylation | RDKAQRYSRGSRVNG HHHHHHHCCCCCCCC | 32.14 | 22871156 | |
25 | Phosphorylation | AQRYSRGSRVNGLPS HHHHCCCCCCCCCCC | 31.76 | 26160508 | |
32 | Phosphorylation | SRVNGLPSPTHSAHC CCCCCCCCCCCCCCC | 47.69 | 18388127 | |
34 | Phosphorylation | VNGLPSPTHSAHCSF CCCCCCCCCCCCCHH | 32.57 | 26824392 | |
36 | Phosphorylation | GLPSPTHSAHCSFYR CCCCCCCCCCCHHHH | 23.37 | 18388127 | |
40 | Phosphorylation | PTHSAHCSFYRTRTL CCCCCCCHHHHHCCH | 18.55 | 26160508 | |
42 | Phosphorylation | HSAHCSFYRTRTLQT CCCCCHHHHHCCHHH | 8.52 | 26160508 | |
44 | Phosphorylation | AHCSFYRTRTLQTLS CCCHHHHHCCHHHHC | 19.34 | 29899451 | |
46 | Phosphorylation | CSFYRTRTLQTLSSE CHHHHHCCHHHHCCC | 23.70 | 24899341 | |
49 | Phosphorylation | YRTRTLQTLSSEKKA HHHCCHHHHCCCCCC | 31.55 | 29899451 | |
51 | Phosphorylation | TRTLQTLSSEKKAKK HCCHHHHCCCCCCCE | 39.58 | 27149854 | |
68 | Phosphorylation | FYRNGDRYFKGIVYA EEECCCCCCEEEEEE | 17.87 | - | |
74 | Phosphorylation | RYFKGIVYAISPDRF CCCEEEEEEECHHHH | 9.04 | 28066266 | |
77 | Phosphorylation | KGIVYAISPDRFRSF EEEEEEECHHHHHCH | 16.75 | 21082442 | |
118 | Phosphorylation | IDGLKKISSLDQLVE ECHHHHHCCHHHHHC | 33.46 | 22807455 | |
119 | Phosphorylation | DGLKKISSLDQLVEG CHHHHHCCHHHHHCC | 39.16 | 19060867 | |
164 | Phosphorylation | TSASRAVSSLATAKG CCHHHHHHHHHHCCC | 20.74 | 26824392 | |
193 | Phosphorylation | KLVTIIRSGVKPRKA HHHHHHHCCCCHHHH | 37.21 | 27149854 | |
209 | Phosphorylation | RILLNKKTAHSFEQV HHHCCCCCCCCHHHH | 31.08 | 25177544 | |
212 | Phosphorylation | LNKKTAHSFEQVLTD CCCCCCCCHHHHHHH | 28.19 | 19060867 | |
283 | Phosphorylation | CRVVKSTSYTKIASA CEEEECCCCEEEEEC | 37.59 | 27149854 | |
284 | Phosphorylation | RVVKSTSYTKIASAS EEEECCCCEEEEECC | 16.49 | 21454597 | |
295 | Phosphorylation | ASASRRGTTKSPGPS EECCCCCCCCCCCCC | 29.28 | 29899451 | |
296 | Phosphorylation | SASRRGTTKSPGPSR ECCCCCCCCCCCCCC | 32.14 | 24453211 | |
298 | Phosphorylation | SRRGTTKSPGPSRRS CCCCCCCCCCCCCCC | 32.75 | 26824392 | |
302 | Phosphorylation | TTKSPGPSRRSKSPA CCCCCCCCCCCCCCC | 46.36 | 23375375 | |
305 | Phosphorylation | SPGPSRRSKSPASTS CCCCCCCCCCCCCCC | 36.05 | 25521595 | |
307 | Phosphorylation | GPSRRSKSPASTSSV CCCCCCCCCCCCCCC | 27.26 | 25521595 | |
310 | Phosphorylation | RRSKSPASTSSVNGT CCCCCCCCCCCCCCC | 32.00 | 21082442 | |
311 | Phosphorylation | RSKSPASTSSVNGTP CCCCCCCCCCCCCCC | 27.42 | 25177544 | |
312 | Phosphorylation | SKSPASTSSVNGTPG CCCCCCCCCCCCCCC | 29.78 | 21082442 | |
313 | Phosphorylation | KSPASTSSVNGTPGS CCCCCCCCCCCCCCC | 21.49 | 25177544 | |
317 | Phosphorylation | STSSVNGTPGSQLST CCCCCCCCCCCCCCC | 21.19 | 25619855 | |
320 | Phosphorylation | SVNGTPGSQLSTPRS CCCCCCCCCCCCCCC | 29.20 | 25619855 | |
323 | Phosphorylation | GTPGSQLSTPRSGKS CCCCCCCCCCCCCCC | 28.82 | 25619855 | |
324 | Phosphorylation | TPGSQLSTPRSGKSP CCCCCCCCCCCCCCC | 31.17 | 25619855 | |
327 | Phosphorylation | SQLSTPRSGKSPSPS CCCCCCCCCCCCCCC | 52.34 | 21082442 | |
330 | Phosphorylation | STPRSGKSPSPSPTS CCCCCCCCCCCCCCC | 33.85 | 25521595 | |
332 (in isoform 2) | Phosphorylation | - | 45.13 | 28285833 | |
332 | Phosphorylation | PRSGKSPSPSPTSPG CCCCCCCCCCCCCCC | 45.13 | 25521595 | |
334 | Phosphorylation | SGKSPSPSPTSPGSL CCCCCCCCCCCCCCC | 45.18 | 25521595 | |
336 (in isoform 2) | Phosphorylation | - | 52.47 | 25521595 | |
336 | Phosphorylation | KSPSPSPTSPGSLRK CCCCCCCCCCCCCCH | 52.47 | 18388127 | |
337 (in isoform 2) | Phosphorylation | - | 30.55 | 25521595 | |
337 | Phosphorylation | SPSPSPTSPGSLRKQ CCCCCCCCCCCCCHH | 30.55 | 25521595 | |
340 (in isoform 2) | Phosphorylation | - | 28.52 | 29899451 | |
340 | Phosphorylation | PSPTSPGSLRKQRIS CCCCCCCCCCHHHHH | 28.52 | 25521595 | |
347 | Phosphorylation | SLRKQRISQHGGSST CCCHHHHHHCCCCCC | 20.50 | 21082442 | |
348 (in isoform 2) | Phosphorylation | - | 36.55 | 27180971 | |
352 | Phosphorylation | RISQHGGSSTSLSST HHHHCCCCCCCCCCC | 34.73 | 18388127 | |
352 (in isoform 2) | Phosphorylation | - | 34.73 | 25177544 | |
353 (in isoform 2) | Phosphorylation | - | 25.87 | 25177544 | |
353 | Phosphorylation | ISQHGGSSTSLSSTK HHHCCCCCCCCCCCC | 25.87 | 25177544 | |
354 | Phosphorylation | SQHGGSSTSLSSTKV HHCCCCCCCCCCCCE | 35.07 | 25177544 | |
355 | Phosphorylation | QHGGSSTSLSSTKVC HCCCCCCCCCCCCEE | 28.35 | 18388127 | |
357 | Phosphorylation | GGSSTSLSSTKVCSS CCCCCCCCCCCEECC | 35.41 | 21082442 | |
358 | Phosphorylation | GSSTSLSSTKVCSSM CCCCCCCCCCEECCC | 37.22 | 26824392 | |
358 (in isoform 2) | Phosphorylation | - | 37.22 | 27149854 | |
359 | Phosphorylation | SSTSLSSTKVCSSMD CCCCCCCCCEECCCC | 24.91 | 29233185 | |
362 (in isoform 2) | Phosphorylation | - | 2.38 | 26824392 | |
363 | Phosphorylation | LSSTKVCSSMDENDG CCCCCEECCCCCCCC | 31.52 | 22324799 | |
364 | Phosphorylation | SSTKVCSSMDENDGP CCCCEECCCCCCCCC | 25.73 | 25521595 | |
382 | Phosphorylation | DELGRRHSLQRGWRR CHHHHHHHHHCCCCH | 25.12 | 22324799 | |
392 | Phosphorylation | RGWRREESEEGFQIP CCCCHHHCCCCCCCC | 35.87 | 25521595 | |
421 | Ubiquitination | DGNFAVVKECIERST CCCCHHHHHHHHHHH | 40.02 | - | |
498 | Ubiquitination | DAITSTSKYTERDAS HHHCCCCCCCCCCHH | 57.17 | - | |
509 | Phosphorylation | RDASGMLYNLASAIK CCHHHHHHHHHHHHH | 10.15 | 22817900 | |
529 | Ubiquitination | NIVHRDIKPENLLVY CCCCCCCCHHHEEEE | 51.04 | - | |
536 | Phosphorylation | KPENLLVYEHQDGSK CHHHEEEEEECCCCC | 13.99 | 22817900 | |
703 | Phosphorylation | AGVSVIATTALDKER HCCEEEEECCCHHHH | 11.07 | 22807455 | |
736 | Phosphorylation | PAPPELNSESEDYSP CCCCCCCCCCCCCCC | 55.94 | 18388127 | |
738 | Phosphorylation | PPELNSESEDYSPSS CCCCCCCCCCCCCCC | 35.27 | 25521595 | |
741 | Phosphorylation | LNSESEDYSPSSSET CCCCCCCCCCCCCCC | 20.59 | 23527152 | |
742 | Phosphorylation | NSESEDYSPSSSETV CCCCCCCCCCCCCCC | 30.54 | 25521595 | |
744 | Phosphorylation | ESEDYSPSSSETVRS CCCCCCCCCCCCCCC | 40.32 | 25521595 | |
745 | Phosphorylation | SEDYSPSSSETVRSP CCCCCCCCCCCCCCC | 35.26 | 21183079 | |
746 | Phosphorylation | EDYSPSSSETVRSPN CCCCCCCCCCCCCCC | 41.44 | 22807455 | |
748 | Phosphorylation | YSPSSSETVRSPNSP CCCCCCCCCCCCCCC | 24.14 | 22817900 | |
751 | Phosphorylation | SSSETVRSPNSPF-- CCCCCCCCCCCCC-- | 24.89 | 19060867 | |
754 | Phosphorylation | ETVRSPNSPF----- CCCCCCCCCC----- | 30.94 | 25521595 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
382 | S | Phosphorylation | Kinase | DCLK1 | Q9JLM8 | PhosphoELM |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCLK1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCLK1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
DCLK1_MOUSE | Dclk1 | physical | 16387639 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-332 ANDSER-337, AND MASS SPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 AND SER-36, AND MASSSPECTROMETRY. | |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-332 ANDTHR-336, AND MASS SPECTROMETRY. | |
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-392, ANDMASS SPECTROMETRY. | |
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307; SER-738AND SER-742, AND MASS SPECTROMETRY. | |
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-509 AND TYR-536, ANDMASS SPECTROMETRY. |