PACS2_MOUSE - dbPTM
PACS2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PACS2_MOUSE
UniProt AC Q3V3Q7
Protein Name Phosphofurin acidic cluster sorting protein 2
Gene Name Pacs2
Organism Mus musculus (Mouse).
Sequence Length 862
Subcellular Localization Endoplasmic reticulum . Mitochondrion .
Protein Description Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments (By similarity)..
Protein Sequence MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLAVLRELEKELLSVVIAVKMQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVMQHPSEGGQVLSLCSSIKEASVKVAEIWIVSLSSQPIDHEDSAMQAGPKTKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSEEVLDSEQDPAEHVPEVEEDLDLLYDTLDVENPSDSGPDMDDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHREPPSPADVPEKTRSLGGKQQLSDSVSDTVALSAAVPREPSGQPEDSPEAETSTLDVFTEKLPPSGRIIKTESLVIPSTRSESKPAGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQKHTLPVVCTCSAADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLIIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSSVQDTPDIVSRITQYISGANCAHQLPIAEAMLTYKQKSPDEESSQRFIPFVGVVKVGIVEPSSATSGDSDDAAPSSSSILSSTPPSASTSPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDMPTTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKTKDKEVESKSQCIEGISRLICTAKHQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
80UbiquitinationFLKREGNKLQIMLQR
HHHCCCCCHHHHHHH		53.26-
214PhosphorylationRSIVRTTSMTRQQNF
HHHHHHCHHHHHHHH		19.97-
222AcetylationMTRQQNFKQKVVALL
HHHHHHHHHHHHHHH		57.6819853477
269PhosphorylationTLDVENPSDSGPDMD
CCCCCCCCCCCCCCC		56.86-
271PhosphorylationDVENPSDSGPDMDDD
CCCCCCCCCCCCCCC		57.47-
292PhosphorylationPKPKLRPYFEGLSHS
CCCCCCCCCCCCCCC		14.0829899451
297PhosphorylationRPYFEGLSHSSSQTE
CCCCCCCCCCCCCCC		31.9820415495
299PhosphorylationYFEGLSHSSSQTEIG
CCCCCCCCCCCCCCC		28.4521183079
300PhosphorylationFEGLSHSSSQTEIGS
CCCCCCCCCCCCCCC		22.5029899451
301PhosphorylationEGLSHSSSQTEIGSI
CCCCCCCCCCCCCCC		44.1026824392
303PhosphorylationLSHSSSQTEIGSIHS
CCCCCCCCCCCCCCC		31.3621183079
307PhosphorylationSSQTEIGSIHSARSH
CCCCCCCCCCCCCCC		23.8425338131
310PhosphorylationTEIGSIHSARSHREP
CCCCCCCCCCCCCCC		24.5725338131
313PhosphorylationGSIHSARSHREPPSP
CCCCCCCCCCCCCCC		26.9825619855
319PhosphorylationRSHREPPSPADVPEK
CCCCCCCCCCCCCHH		43.3625521595
343PhosphorylationLSDSVSDTVALSAAV
CCCCHHHHHHHEECC		10.5229109428
355PhosphorylationAAVPREPSGQPEDSP
ECCCCCCCCCCCCCC		45.3627180971
361PhosphorylationPSGQPEDSPEAETST
CCCCCCCCCCCCCCC		23.9925521595
366PhosphorylationEDSPEAETSTLDVFT
CCCCCCCCCCCHHHH		33.7829899451
367PhosphorylationDSPEAETSTLDVFTE
CCCCCCCCCCHHHHC		20.6229472430
368PhosphorylationSPEAETSTLDVFTEK
CCCCCCCCCHHHHCC		34.1029472430
385PhosphorylationPSGRIIKTESLVIPS
CCCCEEEEEEEEECC		22.0129899451
387PhosphorylationGRIIKTESLVIPSTR
CCEEEEEEEEECCCC		32.9226824392
392PhosphorylationTESLVIPSTRSESKP
EEEEEECCCCCCCCC		25.9022324799
393PhosphorylationESLVIPSTRSESKPA
EEEEECCCCCCCCCC		32.6222324799
397PhosphorylationIPSTRSESKPAGRRG
ECCCCCCCCCCCCCC		45.2328059163
406PhosphorylationPAGRRGRSTSLKERQ
CCCCCCCCCCHHHCC		25.7725177544
407PhosphorylationAGRRGRSTSLKERQP
CCCCCCCCCHHHCCC		36.4030635358
408PhosphorylationGRRGRSTSLKERQPA
CCCCCCCCHHHCCCC		38.4025177544
424PhosphorylationPQNERANSLDNERCP
CCCHHHHCCCCCCCC		35.7925521595
634PhosphorylationMLTYKQKSPDEESSQ
HHHHHCCCCCHHHHH		34.7829899451
658PhosphorylationKVGIVEPSSATSGDS
EEEEECCCCCCCCCC		21.0624759943
659PhosphorylationVGIVEPSSATSGDSD
EEEECCCCCCCCCCC		46.4021183079
661PhosphorylationIVEPSSATSGDSDDA
EECCCCCCCCCCCCC		34.8821183079
662PhosphorylationVEPSSATSGDSDDAA
ECCCCCCCCCCCCCC		40.0827180971
665PhosphorylationSSATSGDSDDAAPSS
CCCCCCCCCCCCCCC		40.7025521595
671PhosphorylationDSDDAAPSSSSILSS
CCCCCCCCCCHHHHC		37.8225293948
672PhosphorylationSDDAAPSSSSILSST
CCCCCCCCCHHHHCC		27.3525293948
673PhosphorylationDDAAPSSSSILSSTP
CCCCCCCCHHHHCCC		26.2419060867
674PhosphorylationDAAPSSSSILSSTPP
CCCCCCCHHHHCCCC		29.5125293948
677PhosphorylationPSSSSILSSTPPSAS
CCCCHHHHCCCCCCC		30.4224759943
678PhosphorylationSSSSILSSTPPSAST
CCCHHHHCCCCCCCC		41.3021183079
679PhosphorylationSSSILSSTPPSASTS
CCHHHHCCCCCCCCC		35.5227180971
682PhosphorylationILSSTPPSASTSPAA
HHHCCCCCCCCCCCH		35.7325293948
684PhosphorylationSSTPPSASTSPAAKE
HCCCCCCCCCCCHHH		33.4825293948
685PhosphorylationSTPPSASTSPAAKEA
CCCCCCCCCCCHHHC		38.1525293948
686PhosphorylationTPPSASTSPAAKEAS
CCCCCCCCCCHHHCC		15.2825293948
693PhosphorylationSPAAKEASPTPPSSP
CCCHHHCCCCCCCCC		30.3325293948
695PhosphorylationAAKEASPTPPSSPSV
CHHHCCCCCCCCCCC		45.3925293948
698PhosphorylationEASPTPPSSPSVSGG
HCCCCCCCCCCCCCC		56.9625293948
699PhosphorylationASPTPPSSPSVSGGL
CCCCCCCCCCCCCCC		27.2825293948
701PhosphorylationPTPPSSPSVSGGLSS
CCCCCCCCCCCCCCC		30.7525293948
703PhosphorylationPPSSPSVSGGLSSPS
CCCCCCCCCCCCCCC		31.3325293948
707PhosphorylationPSVSGGLSSPSQGVG
CCCCCCCCCCCCCCC		43.4025293948
708PhosphorylationSVSGGLSSPSQGVGA
CCCCCCCCCCCCCCH		33.3425293948
710PhosphorylationSGGLSSPSQGVGAEL
CCCCCCCCCCCCHHH		41.3325293948
724PhosphorylationLMGLQVDYWTAAQPA
HCCEEEEEEECCCCC		13.0525293948
726PhosphorylationGLQVDYWTAAQPADR
CEEEEEEECCCCCHH		13.0925293948
800PhosphorylationTKDKEVESKSQCIEG
CCCCHHHCHHHHHHH		42.6620139300
802PhosphorylationDKEVESKSQCIEGIS
CCHHHCHHHHHHHHH		39.2920139300
809PhosphorylationSQCIEGISRLICTAK
HHHHHHHHHHHHHHH		31.7120139300
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PACS2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PACS2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PACS2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PACS2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PACS2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, AND MASSSPECTROMETRY.

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