PSA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA1_MOUSE
• UniProt AC: Q9R1P4
• Protein Name: Proteasome subunit alpha type-1
• Gene Name: Psma1
• Organism: Mus musculus (Mouse).
• Sequence Length: 263
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFRNQYDN -------CCCCCCCC	6.85	-
14	Phosphorylation	DNDVTVWSPQGRIHQ CCCCEEECCCCCCHH	11.74	26745281
30	Acetylation	EYAMEAVKQGSATVG HHHHHHHHCCCCEEE	56.86	63820447
30	Ubiquitination	EYAMEAVKQGSATVG HHHHHHHHCCCCEEE	56.86	-
33	Phosphorylation	MEAVKQGSATVGLKS HHHHHCCCCEEECCC	20.48	28464351
41	Acetylation	ATVGLKSKTHAVLVA CEEECCCHHHHHHHH	42.62	22826441
50	Acetylation	HAVLVALKRAQSELA HHHHHHHHHHHHHHH	35.63	22826441
54	Phosphorylation	VALKRAQSELAAHQK HHHHHHHHHHHHHHH	33.33	28066266
85	S-palmitoylation	TADARLLCNFMRQEC CCCHHHHHHHHHHHH	4.34	28526873
85	S-nitrosylation	TADARLLCNFMRQEC CCCHHHHHHHHHHHH	4.34	21278135
85	Glutathionylation	TADARLLCNFMRQEC CCCHHHHHHHHHHHH	4.34	24333276
85	S-nitrosocysteine	TADARLLCNFMRQEC CCCHHHHHHHHHHHH	4.34	-
92	S-nitrosocysteine	CNFMRQECLDSRFVF HHHHHHHHHCCCCCC	3.76	-
92	S-nitrosylation	CNFMRQECLDSRFVF HHHHHHHHHCCCCCC	3.76	21278135
110	Phosphorylation	LPVSRLVSLIGSKTQ CCHHHHHHHHCCCCC	20.89	25521595
110	O-linked_Glycosylation	LPVSRLVSLIGSKTQ CCHHHHHHHHCCCCC	20.89	22556278
114	Phosphorylation	RLVSLIGSKTQIPTQ HHHHHHCCCCCCCCC	26.07	28833060
115	Ubiquitination	LVSLIGSKTQIPTQR HHHHHCCCCCCCCCC	38.96	-
115	Acetylation	LVSLIGSKTQIPTQR HHHHHCCCCCCCCCC	38.96	63820449
116	Phosphorylation	VSLIGSKTQIPTQRY HHHHCCCCCCCCCCC	33.17	24719451
177	Phosphorylation	TYLERHMSEFMECNL HHHHHHHHHHHHCCH	22.89	22817900
182	S-palmitoylation	HMSEFMECNLDELVK HHHHHHHCCHHHHHH	4.04	28680068
189	Acetylation	CNLDELVKHGLRALR CCHHHHHHHHHHHHH	44.58	22826441
208	Ubiquitination	AEQDLTTKNVSIGIV CCCCCCCCCEEEEEE	50.55	-
243	Ubiquitination	LEERPQRKAQPSQAA CHHCCCHHCCCCHHH	46.24	-
247	Phosphorylation	PQRKAQPSQAAEEPA CCHHCCCCHHHHCHH	21.99	25521595
256	Ubiquitination	AAEEPAEKADEPMEH HHHCHHHHCCCCCCC	64.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZFN2A_MOUSE	Zfand2a	physical	16973439
UBC_MOUSE	Ubc	physical	16973439
PSMD7_MOUSE	Psmd7	physical	16973439

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.